3-hydroxy-DL-kynurenine-5276 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the 3-hydroxy-DL-kynurenine-5276 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN1 actinin, alpha 1
ADCK2 aarF domain containing kinase 2
AHSP alpha hemoglobin stabilizing protein
AKAP8L A kinase (PRKA) anchor protein 8-like
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BAX BCL2-associated X protein
BCL7A B-cell CLL/lymphoma 7A
BST2 bone marrow stromal cell antigen 2
C6ORF10 chromosome 6 open reading frame 10
CALML5 calmodulin-like 5
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARTPT CART prepropeptide
CD3D CD3d molecule, delta (CD3-TCR complex)
CD52 CD52 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A1 collagen, type I, alpha 1
CRMP1 collapsin response mediator protein 1
CUEDC1 CUE domain containing 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DIO2 deiodinase, iodothyronine, type II
DLC1 DLC1 Rho GTPase activating protein
EFNB3 ephrin-B3
F2RL2 coagulation factor II (thrombin) receptor-like 2
FMO5 flavin containing monooxygenase 5
FRMD4A FERM domain containing 4A
GGT1 gamma-glutamyltransferase 1
GPR137 G protein-coupled receptor 137
GPR143 G protein-coupled receptor 143
GREB1 growth regulation by estrogen in breast cancer 1
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
HCG4 HLA complex group 4 (non-protein coding)
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KHSRP KH-type splicing regulatory protein
KLF13 Kruppel-like factor 13
MED25 mediator complex subunit 25
MEF2D myocyte enhancer factor 2D
MID1 midline 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NYNRIN NYN domain and retroviral integrase containing
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PADI3 peptidyl arginine deiminase, type III
PBX2 pre-B-cell leukemia homeobox 2
PDGFA platelet-derived growth factor alpha polypeptide
PHF20L1 PHD finger protein 20-like 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAT plasminogen activator, tissue
PPP1R10 protein phosphatase 1, regulatory subunit 10
PQLC2 PQ loop repeat containing 2
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PVT1 Pvt1 oncogene (non-protein coding)
RABGAP1L RAB GTPase activating protein 1-like
RBM5 RNA binding motif protein 5
REEP2 receptor accessory protein 2
REST RE1-silencing transcription factor
RUNX1 runt-related transcription factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC3 syndecan 3
SF1 splicing factor 1
SFRP4 secreted frizzled-related protein 4
SH3BP2 SH3-domain binding protein 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC35E2 solute carrier family 35, member E2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMG7 SMG7 nonsense mediated mRNA decay factor
SP100 SP100 nuclear antigen
STK24 serine/threonine kinase 24
TBC1D2 TBC1 domain family, member 2
TBR1 T-box, brain, 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNPO2 transportin 2
TPSG1 tryptase gamma 1
TRD T cell receptor delta locus
UNC119 unc-119 homolog (C. elegans)
USP2 ubiquitin specific peptidase 2
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
ZFHX2 zinc finger homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF124 zinc finger protein 124
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADTRP androgen-dependent TFPI-regulating protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATF3 activating transcription factor 3
BBC3 BCL2 binding component 3
BTF3P11 basic transcription factor 3 pseudogene 11
C4ORF29 chromosome 4 open reading frame 29
CAMK4 calcium/calmodulin-dependent protein kinase IV
CEP295 centrosomal protein 295kDa
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CRY2 cryptochrome circadian clock 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNAH17 dynein, axonemal, heavy chain 17
DNM3 dynamin 3
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FLCN folliculin
FRMD1 FERM domain containing 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
GRB7 growth factor receptor-bound protein 7
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTP1 glutathione S-transferase pi 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HLA-DMA major histocompatibility complex, class II, DM alpha
KLHL25 kelch-like family member 25
KPNA5 karyopherin alpha 5 (importin alpha 6)
LGALS4 lectin, galactoside-binding, soluble, 4
LIN7A lin-7 homolog A (C. elegans)
LRRC37A3 leucine rich repeat containing 37, member A3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MTCP1 mature T-cell proliferation 1
MYOZ3 myozenin 3
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
OVOL1 ovo-like zinc finger 1
PADI1 peptidyl arginine deiminase, type I
PCDHA5 protocadherin alpha 5
PCDHB13 protocadherin beta 13
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIPOX pipecolic acid oxidase
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRSS53 protease, serine, 53
RAB3D RAB3D, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RLN1 relaxin 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF39 ring finger protein 39
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SECTM1 secreted and transmembrane 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SP140L SP140 nuclear body protein-like
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STRN striatin, calmodulin binding protein
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TEP1 telomerase-associated protein 1
TEX40 testis expressed 40
TMPRSS3 transmembrane protease, serine 3
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRAIP TRAF interacting protein
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TYRP1 tyrosinase-related protein 1
UBQLN4 ubiquilin 4
VIM vimentin
VLDLR very low density lipoprotein receptor
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF480 zinc finger protein 480
ZNF484 zinc finger protein 484
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862