3-hydroxy-DL-kynurenine-2654 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the 3-hydroxy-DL-kynurenine-2654 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGRP agouti related neuropeptide
AKAP11 A kinase (PRKA) anchor protein 11
AKAP7 A kinase (PRKA) anchor protein 7
ALPPL2 alkaline phosphatase, placental-like 2
ARHGAP35 Rho GTPase activating protein 35
ASIC1 acid sensing (proton gated) ion channel 1
BAIAP3 BAI1-associated protein 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C10ORF95 chromosome 10 open reading frame 95
C1ORF61 chromosome 1 open reading frame 61
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCL21 chemokine (C-C motif) ligand 21
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
CPNE7 copine VII
CSF1 colony stimulating factor 1 (macrophage)
CTSE cathepsin E
ELOVL5 ELOVL fatty acid elongase 5
ETV7 ets variant 7
EXOSC1 exosome component 1
FBXO41 F-box protein 41
FGFR1 fibroblast growth factor receptor 1
FOSL2 FOS-like antigen 2
FOXP3 forkhead box P3
FRMD4B FERM domain containing 4B
FSCN1 fascin actin-bundling protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA4 GATA binding protein 4
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPSM3 G-protein signaling modulator 3
GSTM5 glutathione S-transferase mu 5
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA4 homeobox A4
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGL immunoglobulin lambda locus
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQSEC2 IQ motif and Sec7 domain 2
KIF1C kinesin family member 1C
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRT31 keratin 31, type I
LIME1 Lck interacting transmembrane adaptor 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY9 lymphocyte antigen 9
MARK4 MAP/microtubule affinity-regulating kinase 4
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MINK1 misshapen-like kinase 1
MRC2 mannose receptor, C type 2
MSX2 msh homeobox 2
MYLK myosin light chain kinase
NCOA2 nuclear receptor coactivator 2
NLE1 notchless homolog 1 (Drosophila)
NOP16 NOP16 nucleolar protein
NPPA natriuretic peptide A
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG2 neuregulin 2
NRIP3 nuclear receptor interacting protein 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDE4DIP phosphodiesterase 4D interacting protein
PIPOX pipecolic acid oxidase
POLM polymerase (DNA directed), mu
PON1 paraoxonase 1
PPP5C protein phosphatase 5, catalytic subunit
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RND1 Rho family GTPase 1
RTN2 reticulon 2
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SDC2 syndecan 2
SEC14L4 SEC14-like 4 (S. cerevisiae)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLN sarcolipin
SNRK SNF related kinase
SNW1 SNW domain containing 1
SPEG SPEG complex locus
SPHK2 sphingosine kinase 2
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TTLL5 tubulin tyrosine ligase-like family member 5
UTRN utrophin
VAC14 Vac14 homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABHD4 abhydrolase domain containing 4
ACAD10 acyl-CoA dehydrogenase family, member 10
ANXA1 annexin A1
ARRB1 arrestin, beta 1
ARSB arylsulfatase B
C12ORF4 chromosome 12 open reading frame 4
C17ORF80 chromosome 17 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CASD1 CAS1 domain containing 1
CLDN15 claudin 15
CRELD1 cysteine-rich with EGF-like domains 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CRYBG3 beta-gamma crystallin domain containing 3
CUL9 cullin 9
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DUSP13 dual specificity phosphatase 13
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELP3 elongator acetyltransferase complex subunit 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXOC5 exocyst complex component 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAAH fatty acid amide hydrolase
FADS3 fatty acid desaturase 3
FAM186A family with sequence similarity 186, member A
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FER fer (fps/fes related) tyrosine kinase
FKBP5 FK506 binding protein 5
GAMT guanidinoacetate N-methyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD3 GRAM domain containing 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
IMPACT impact RWD domain protein
INPPL1 inositol polyphosphate phosphatase-like 1
IPO8 importin 8
KIAA0513 KIAA0513
KIF13B kinesin family member 13B
KIFAP3 kinesin-associated protein 3
KLF11 Kruppel-like factor 11
LARP6 La ribonucleoprotein domain family, member 6
LIG4 ligase IV, DNA, ATP-dependent
LINC00339 long intergenic non-protein coding RNA 339
LOC390998 ribosomal protein L10 pseudogene
LYPD1 LY6/PLAUR domain containing 1
LZTFL1 leucine zipper transcription factor-like 1
MAP1S microtubule-associated protein 1S
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MTMR12 myotubularin related protein 12
NDE1 nudE neurodevelopment protein 1
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NKX3-2 NK3 homeobox 2
NPY5R neuropeptide Y receptor Y5
NRSN2 neurensin 2
NUBPL nucleotide binding protein-like
PARP16 poly (ADP-ribose) polymerase family, member 16
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCH pro-melanin-concentrating hormone
PRICKLE3 prickle homolog 3 (Drosophila)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR14L proline rich 14-like
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QTRT1 queuine tRNA-ribosyltransferase 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFTN1 raftlin, lipid raft linker 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF122 ring finger protein 122
SKA1 spindle and kinetochore associated complex subunit 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRYD7 SPRY domain containing 7
STK16 serine/threonine kinase 16
TCHH trichohyalin
TCTA T-cell leukemia translocation altered
TMEM2 transmembrane protein 2
TMEM260 transmembrane protein 260
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBQLN4 ubiquilin 4
ZNF324 zinc finger protein 324
ZNF34 zinc finger protein 34
ZNF510 zinc finger protein 510
ZNF571 zinc finger protein 571
ZNF654 zinc finger protein 654
ZNF74 zinc finger protein 74
ZSCAN26 zinc finger and SCAN domain containing 26