3-hydroxy-DL-kynurenine-1300 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the 3-hydroxy-DL-kynurenine-1300 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD12 ankyrin repeat domain 12
APP amyloid beta (A4) precursor protein
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
BAX BCL2-associated X protein
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BLVRA biliverdin reductase A
BMP1 bone morphogenetic protein 1
BMP2K BMP2 inducible kinase
BTBD18 BTB (POZ) domain containing 18
CARD14 caspase recruitment domain family, member 14
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDK10 cyclin-dependent kinase 10
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHN2 chimerin 2
COMT catechol-O-methyltransferase
COX4I1 cytochrome c oxidase subunit IV isoform 1
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CYB561 cytochrome b561
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHRS12 dehydrogenase/reductase (SDR family) member 12
DIAPH1 diaphanous-related formin 1
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EML3 echinoderm microtubule associated protein like 3
ESRRA estrogen-related receptor alpha
EXPH5 exophilin 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
FZD7 frizzled class receptor 7
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GUSBP3 glucuronidase, beta pseudogene 3
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H2AJ histone cluster 1, H2aj
HOXA1 homeobox A1
IFI30 interferon, gamma-inducible protein 30
INF2 inverted formin, FH2 and WH2 domain containing
IQSEC1 IQ motif and Sec7 domain 1
ITM2B integral membrane protein 2B
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED16 mediator complex subunit 16
MRPL4 mitochondrial ribosomal protein L4
MTRF1L mitochondrial translational release factor 1-like
NFYA nuclear transcription factor Y, alpha
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PDZD7 PDZ domain containing 7
PNPLA4 patatin-like phospholipase domain containing 4
PPARD peroxisome proliferator-activated receptor delta
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTCH1 patched 1
RAP1GAP RAP1 GTPase activating protein
RNF216 ring finger protein 216
RPS2 ribosomal protein S2
SALL2 spalt-like transcription factor 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLITRK5 SLIT and NTRK-like family, member 5
SMYD2 SET and MYND domain containing 2
SOGA1 suppressor of glucose, autophagy associated 1
SPATA2L spermatogenesis associated 2-like
SPN sialophorin
SRD5A3 steroid 5 alpha-reductase 3
ST5 suppression of tumorigenicity 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STOML1 stomatin (EPB72)-like 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TBC1D4 TBC1 domain family, member 4
TCP11L1 t-complex 11, testis-specific-like 1
TEX261 testis expressed 261
TIMP2 TIMP metallopeptidase inhibitor 2
TLE4 transducin-like enhancer of split 4
TMEM134 transmembrane protein 134
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TRAF3 TNF receptor-associated factor 3
TRIM33 tripartite motif containing 33
TSPAN2 tetraspanin 2
TWIST1 twist family bHLH transcription factor 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
USP34 ubiquitin specific peptidase 34
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZMYM2 zinc finger, MYM-type 2
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
ANKHD1 ankyrin repeat and KH domain containing 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ASGR2 asialoglycoprotein receptor 2
ATAD3A ATPase family, AAA domain containing 3A
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AXIN1 axin 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BPGM 2,3-bisphosphoglycerate mutase
C11ORF49 chromosome 11 open reading frame 49
C17ORF70 chromosome 17 open reading frame 70
C1ORF109 chromosome 1 open reading frame 109
C1ORF56 chromosome 1 open reading frame 56
C22ORF46 chromosome 22 open reading frame 46
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
C8ORF44 chromosome 8 open reading frame 44
CENPT centromere protein T
CEP170B centrosomal protein 170B
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CNN2 calponin 2
COG7 component of oligomeric golgi complex 7
CTNNBIP1 catenin, beta interacting protein 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DEAF1 DEAF1 transcription factor
DHRS7B dehydrogenase/reductase (SDR family) member 7B
ECI2 enoyl-CoA delta isomerase 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERI3 ERI1 exoribonuclease family member 3
ERMP1 endoplasmic reticulum metallopeptidase 1
EVI2B ecotropic viral integration site 2B
EXOC5 exocyst complex component 5
FAM206A family with sequence similarity 206, member A
FCHO1 FCH domain only 1
FEM1C fem-1 homolog c (C. elegans)
FHL3 four and a half LIM domains 3
FKBPL FK506 binding protein like
GDAP2 ganglioside induced differentiation associated protein 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GOLGA8B golgin A8 family, member B
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM3 interferon induced transmembrane protein 3
IFT46 intraflagellar transport 46
JMJD4 jumonji domain containing 4
JUP junction plakoglobin
KAT2A K(lysine) acetyltransferase 2A
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KLHL26 kelch-like family member 26
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LRRK1 leucine-rich repeat kinase 1
MBD5 methyl-CpG binding domain protein 5
MBTD1 mbt domain containing 1
MDM4 MDM4, p53 regulator
MIR22HG MIR22 host gene
MST1 macrophage stimulating 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NPFFR1 neuropeptide FF receptor 1
PAQR6 progestin and adipoQ receptor family member VI
PARG poly (ADP-ribose) glycohydrolase
PARPBP PARP1 binding protein
PBLD phenazine biosynthesis-like protein domain containing
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PMCH pro-melanin-concentrating hormone
PRR14L proline rich 14-like
PTTG1 pituitary tumor-transforming 1
QTRT1 queuine tRNA-ribosyltransferase 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RNF141 ring finger protein 141
RNF25 ring finger protein 25
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNX16 sorting nexin 16
STEAP3 STEAP family member 3, metalloreductase
TET3 tet methylcytosine dioxygenase 3
TMOD3 tropomodulin 3 (ubiquitous)
TNNT1 troponin T type 1 (skeletal, slow)
TOLLIP toll interacting protein
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH1 vasohibin 1
WT1-AS WT1 antisense RNA
ZC2HC1A zinc finger, C2HC-type containing 1A
ZHX2 zinc fingers and homeoboxes 2
ZNF230 zinc finger protein 230
ZNF280D zinc finger protein 280D
ZNF37BP zinc finger protein 37B, pseudogene
ZNF574 zinc finger protein 574
ZW10 zw10 kinetochore protein