3-acetylcoumarin-4664 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the 3-acetylcoumarin-4664 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADTRP androgen-dependent TFPI-regulating protein
AGXT alanine-glyoxylate aminotransferase
ANGPTL4 angiopoietin-like 4
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARHGAP25 Rho GTPase activating protein 25
ASPHD1 aspartate beta-hydroxylase domain containing 1
C1ORF116 chromosome 1 open reading frame 116
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CLCA2 chloride channel accessory 2
CPED1 cadherin-like and PC-esterase domain containing 1
CRHR2 corticotropin releasing hormone receptor 2
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DRP2 dystrophin related protein 2
DUSP1 dual specificity phosphatase 1
ERO1LB ERO1-like beta (S. cerevisiae)
ESRRG estrogen-related receptor gamma
FBRS fibrosin
FRS3 fibroblast growth factor receptor substrate 3
FZD1 frizzled class receptor 1
GK3P glycerol kinase 3 pseudogene
GRIK3 glutamate receptor, ionotropic, kainate 3
GZMK granzyme K (granzyme 3; tryptase II)
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIPK3 homeodomain interacting protein kinase 3
HIST1H4A histone cluster 1, H4a
HIST1H4D histone cluster 1, H4d
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1B interleukin 1, beta
INS insulin
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPK1 inositol-tetrakisphosphate 1-kinase
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF12 Kruppel-like factor 12
LPIN1 lipin 1
LRP4 low density lipoprotein receptor-related protein 4
MAP2K5 mitogen-activated protein kinase kinase 5
MEP1B meprin A, beta
MRPL20 mitochondrial ribosomal protein L20
MTMR7 myotubularin related protein 7
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCF4 neutrophil cytosolic factor 4, 40kDa
NOD2 nucleotide-binding oligomerization domain containing 2
NPY2R neuropeptide Y receptor Y2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAEP progestagen-associated endometrial protein
PAX2 paired box 2
PCNX pecanex homolog (Drosophila)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD2L2 polycystic kidney disease 2-like 2
PLIN2 perilipin 2
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTH1R parathyroid hormone 1 receptor
RAD51D RAD51 paralog D
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RB1 retinoblastoma 1
RGR retinal G protein coupled receptor
RPS14 ribosomal protein S14
SENP5 SUMO1/sentrin specific peptidase 5
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC16A6 solute carrier family 16, member 6
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STOML1 stomatin (EPB72)-like 1
STX7 syntaxin 7
TAAR5 trace amine associated receptor 5
TAT tyrosine aminotransferase
TET3 tet methylcytosine dioxygenase 3
TFDP3 transcription factor Dp family, member 3
TMEM257 transmembrane protein 257
TRIM2 tripartite motif containing 2
TROVE2 TROVE domain family, member 2
TTC12 tetratricopeptide repeat domain 12
TUBB2B tubulin, beta 2B class IIb
UBE2B ubiquitin-conjugating enzyme E2B
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VIPR2 vasoactive intestinal peptide receptor 2
WDR55 WD repeat domain 55
XAF1 XIAP associated factor 1
ZFP37 ZFP37 zinc finger protein
ZNF268 zinc finger protein 268
ZNF440 zinc finger protein 440
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM2 ADAM metallopeptidase domain 2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AMT aminomethyltransferase
ANKZF1 ankyrin repeat and zinc finger domain containing 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C11ORF30 chromosome 11 open reading frame 30
C14ORF105 chromosome 14 open reading frame 105
C19ORF54 chromosome 19 open reading frame 54
C7ORF43 chromosome 7 open reading frame 43
CALCOCO1 calcium binding and coiled-coil domain 1
CAMKMT calmodulin-lysine N-methyltransferase
CCDC106 coiled-coil domain containing 106
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD79A CD79a molecule, immunoglobulin-associated alpha
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CSRNP3 cysteine-serine-rich nuclear protein 3
CYBRD1 cytochrome b reductase 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
EDAR ectodysplasin A receptor
EDN1 endothelin 1
ELSPBP1 epididymal sperm binding protein 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPPK1 epiplakin 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM120C family with sequence similarity 120C
FAM131A family with sequence similarity 131, member A
FAM160B2 family with sequence similarity 160, member B2
FAM188A family with sequence similarity 188, member A
FAM53B family with sequence similarity 53, member B
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO4 flavin containing monooxygenase 4
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FUZ fuzzy planar cell polarity protein
GALT galactose-1-phosphate uridylyltransferase
GPR1 G protein-coupled receptor 1
GPR27 G protein-coupled receptor 27
HAMP hepcidin antimicrobial peptide
HIST1H1T histone cluster 1, H1t
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3I histone cluster 1, H3i
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT140 intraflagellar transport 140
IL32 interleukin 32
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
KIAA0513 KIAA0513
KIFC1 kinesin family member C1
KLHL25 kelch-like family member 25
LAMC3 laminin, gamma 3
LINC00597 long intergenic non-protein coding RNA 597
LRP5L low density lipoprotein receptor-related protein 5-like
MAST3 microtubule associated serine/threonine kinase 3
MUC3B mucin 3B, cell surface associated
MYOZ1 myozenin 1
NDP Norrie disease (pseudoglioma)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL10 nucleolar protein 10
OCA2 oculocutaneous albinism II
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARM1 prostate androgen-regulated mucin-like protein 1
PCOLCE procollagen C-endopeptidase enhancer
PDIA3 protein disulfide isomerase family A, member 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
RABL6 RAB, member RAS oncogene family-like 6
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIBC2 RIB43A domain with coiled-coils 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SHROOM2 shroom family member 2
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STEAP4 STEAP family member 4
SUGCT succinyl-CoA:glutarate-CoA transferase
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYNGR3 synaptogyrin 3
SYT17 synaptotagmin XVII
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TGFBI transforming growth factor, beta-induced, 68kDa
THRAP3 thyroid hormone receptor associated protein 3
TMEM180 transmembrane protein 180
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAPPC6A trafficking protein particle complex 6A
ZBTB22 zinc finger and BTB domain containing 22
ZNF14 zinc finger protein 14
ZNF141 zinc finger protein 141
ZNF528 zinc finger protein 528