3-acetamidocoumarin-4426 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the 3-acetamidocoumarin-4426 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AIF1 allograft inflammatory factor 1
AP3B2 adaptor-related protein complex 3, beta 2 subunit
APAF1 apoptotic peptidase activating factor 1
APOL6 apolipoprotein L, 6
ATG10 autophagy related 10
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BEX1 brain expressed, X-linked 1
CDC14B cell division cycle 14B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEL carboxyl ester lipase
CHM choroideremia (Rab escort protein 1)
CLCA2 chloride channel accessory 2
COL6A1 collagen, type VI, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNS cystinosin, lysosomal cystine transporter
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEFA4 defensin, alpha 4, corticostatin
DNASE1 deoxyribonuclease I
DYM dymeclin
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F5 E2F transcription factor 5, p130-binding
EGF epidermal growth factor
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL2 FOS-like antigen 2
GGT1 gamma-glutamyltransferase 1
GLIPR1 GLI pathogenesis-related 1
GM2A GM2 ganglioside activator
GPR182 G protein-coupled receptor 182
GPSM3 G-protein signaling modulator 3
GRPR gastrin-releasing peptide receptor
HAS1 hyaluronan synthase 1
HCRTR2 hypocretin (orexin) receptor 2
HHLA2 HERV-H LTR-associating 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LIMK1 LIM domain kinase 1
LRRC61 leucine rich repeat containing 61
LSP1 lymphocyte-specific protein 1
MAGEA5 melanoma antigen family A5
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEU3 sialidase 3 (membrane sialidase)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPR1 natriuretic peptide receptor 1
PARVB parvin, beta
PCDHB6 protocadherin beta 6
PGK1 phosphoglycerate kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU3F1 POU class 3 homeobox 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRB3 proline-rich protein BstNI subfamily 3
PRDX2 peroxiredoxin 2
PRM1 protamine 1
PTAFR platelet-activating factor receptor
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS10 regulator of G-protein signaling 10
RPAIN RPA interacting protein
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35E2 solute carrier family 35, member E2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPTB spectrin, beta, erythrocytic
SPTBN2 spectrin, beta, non-erythrocytic 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAB2 stabilin 2
STK24 serine/threonine kinase 24
SYT5 synaptotagmin V
TCF12 transcription factor 12
TECPR2 tectonin beta-propeller repeat containing 2
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TSC22D2 TSC22 domain family, member 2
TWF1 twinfilin actin binding protein 1
TYRP1 tyrosinase-related protein 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VDAC3 voltage-dependent anion channel 3
VN1R1 vomeronasal 1 receptor 1
WAPAL wings apart-like homolog (Drosophila)
WSB1 WD repeat and SOCS box containing 1
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
ADM adrenomedullin
ADTRP androgen-dependent TFPI-regulating protein
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC4 armadillo repeat containing 4
ARPIN actin-related protein 2/3 complex inhibitor
ART1 ADP-ribosyltransferase 1
BAX BCL2-associated X protein
BTF3P11 basic transcription factor 3 pseudogene 11
C4ORF29 chromosome 4 open reading frame 29
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNO cyclin O
CDHR2 cadherin-related family member 2
CXXC4 CXXC finger protein 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DGKQ diacylglycerol kinase, theta 110kDa
EMID1 EMI domain containing 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERN1 endoplasmic reticulum to nucleus signaling 1
EXO5 exonuclease 5
FAM131A family with sequence similarity 131, member A
GINS4 GINS complex subunit 4 (Sld5 homolog)
GK2 glycerol kinase 2
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPC3 glypican 3
GPR3 G protein-coupled receptor 3
GRTP1 growth hormone regulated TBC protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HHAT hedgehog acyltransferase
HIRA histone cell cycle regulator
HIST1H3E histone cluster 1, H3e
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
HOXC8 homeobox C8
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM7A lysine (K)-specific demethylase 7A
KIAA0319L KIAA0319-like
KIFC1 kinesin family member C1
KRT24 keratin 24, type I
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEGF8 multiple EGF-like-domains 8
MRPL41 mitochondrial ribosomal protein L41
MX2 MX dynamin-like GTPase 2
MYO1F myosin IF
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCLM oculomedin
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGA10 protocadherin gamma subfamily A, 10
PDE8B phosphodiesterase 8B
PDZD2 PDZ domain containing 2
PGPEP1 pyroglutamyl-peptidase I
PHOX2A paired-like homeobox 2a
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G3 phospholipase A2, group III
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPAG4 sperm associated antigen 4
SPRR2B small proline-rich protein 2B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAS2R10 taste receptor, type 2, member 10
TBL1Y transducin (beta)-like 1, Y-linked
TEP1 telomerase-associated protein 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM21 tripartite motif containing 21
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
VGF VGF nerve growth factor inducible
VIM vimentin
WDR76 WD repeat domain 76
ZNF205 zinc finger protein 205
ZNF652 zinc finger protein 652
ZSWIM1 zinc finger, SWIM-type containing 1