2,6-dimethylpiperidine-6049 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the 2,6-dimethylpiperidine-6049 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADPRH ADP-ribosylarginine hydrolase
ANGPT4 angiopoietin 4
ARL3 ADP-ribosylation factor-like 3
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BIN1 bridging integrator 1
C2ORF27A chromosome 2 open reading frame 27A
C9ORF16 chromosome 9 open reading frame 16
CACFD1 calcium channel flower domain containing 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC88A coiled-coil domain containing 88A
CD1E CD1e molecule
CD53 CD53 molecule
CDK6 cyclin-dependent kinase 6
CEP250 centrosomal protein 250kDa
CFAP74 cilia and flagella associated protein 74
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CORO2B coronin, actin binding protein, 2B
CSN1S1 casein alpha s1
CTRL chymotrypsin-like
CUL3 cullin 3
DOK4 docking protein 4
ECE1 endothelin converting enzyme 1
EPHB2 EPH receptor B2
F12 coagulation factor XII (Hageman factor)
FAM46C family with sequence similarity 46, member C
FKRP fukutin related protein
GAS7 growth arrest-specific 7
GPATCH4 G patch domain containing 4
HFE hemochromatosis
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA11 homeobox A11
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IBSP integrin-binding sialoprotein
IRF8 interferon regulatory factor 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JADE2 jade family PHD finger 2
KALRN kalirin, RhoGEF kinase
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0895 KIAA0895
KIAA1109 KIAA1109
KIF1C kinesin family member 1C
KLK13 kallikrein-related peptidase 13
LAT2 linker for activation of T cells family, member 2
LEFTY1 left-right determination factor 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MASP2 mannan-binding lectin serine peptidase 2
MEG3 maternally expressed 3 (non-protein coding)
MFSD7 major facilitator superfamily domain containing 7
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MNDA myeloid cell nuclear differentiation antigen
MST1R macrophage stimulating 1 receptor
MYOZ3 myozenin 3
MZF1 myeloid zinc finger 1
NOX1 NADPH oxidase 1
NPTXR neuronal pentraxin receptor
NPY neuropeptide Y
PAWR PRKC, apoptosis, WT1, regulator
PDIA2 protein disulfide isomerase family A, member 2
PLSCR2 phospholipid scramblase 2
PON3 paraoxonase 3
PRODH2 proline dehydrogenase (oxidase) 2
PVR poliovirus receptor
PWAR5 Prader Willi/Angelman region RNA 5
RAB3B RAB3B, member RAS oncogene family
RELN reelin
RFPL1S RFPL1 antisense RNA 1
RFPL3 ret finger protein-like 3
RGS14 regulator of G-protein signaling 14
SATB2 SATB homeobox 2
SCAMP1 secretory carrier membrane protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2D3A SH2 domain containing 3A
SIRT5 sirtuin 5
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
STC1 stanniocalcin 1
STMN4 stathmin-like 4
TBCD tubulin folding cofactor D
TCF3 transcription factor 3
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TP63 tumor protein p63
TRD T cell receptor delta locus
USP22 ubiquitin specific peptidase 22
WDR55 WD repeat domain 55
WDR59 WD repeat domain 59
WNT8B wingless-type MMTV integration site family, member 8B
ZFHX2 zinc finger homeobox 2
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALS2CL ALS2 C-terminal like
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMCX2 armadillo repeat containing, X-linked 2
ART1 ADP-ribosyltransferase 1
ATAD3A ATPase family, AAA domain containing 3A
BAHCC1 BAH domain and coiled-coil containing 1
BMP15 bone morphogenetic protein 15
C5AR2 complement component 5a receptor 2
CALCOCO1 calcium binding and coiled-coil domain 1
CD8A CD8a molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CHML choroideremia-like (Rab escort protein 2)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNR2 cannabinoid receptor 2 (macrophage)
CRLF1 cytokine receptor-like factor 1
CXADR coxsackie virus and adenovirus receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DES desmin
DGKE diacylglycerol kinase, epsilon 64kDa
DMTN dematin actin binding protein
DNM3 dynamin 3
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EN2 engrailed homeobox 2
ENO3 enolase 3 (beta, muscle)
EPHA2 EPH receptor A2
ERCC6 excision repair cross-complementation group 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM131A family with sequence similarity 131, member A
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMOD fibromodulin
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLS2 glutaminase 2 (liver, mitochondrial)
HAND1 heart and neural crest derivatives expressed 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IL22 interleukin 22
INO80D INO80 complex subunit D
LIG4 ligase IV, DNA, ATP-dependent
LINC00597 long intergenic non-protein coding RNA 597
LMX1B LIM homeobox transcription factor 1, beta
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC20 leucine rich repeat containing 20
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP2 microtubule-associated protein 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MMP3 matrix metallopeptidase 3
MORN1 MORN repeat containing 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NDE1 nudE neurodevelopment protein 1
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PADI1 peptidyl arginine deiminase, type I
PMCH pro-melanin-concentrating hormone
PODNL1 podocan-like 1
PRSS53 protease, serine, 53
RAB3D RAB3D, member RAS oncogene family
RGCC regulator of cell cycle
RNF2 ring finger protein 2
RWDD3 RWD domain containing 3
S100A2 S100 calcium binding protein A2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIPA1 signal-induced proliferation-associated 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SP1 Sp1 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STRA6 stimulated by retinoic acid 6
TCTN2 tectonic family member 2
TESC tescalcin
TH tyrosine hydroxylase
TMPRSS4 transmembrane protease, serine 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTLL1 tubulin tyrosine ligase-like family member 1
VIPR1 vasoactive intestinal peptide receptor 1
VPS9D1 VPS9 domain containing 1
WDR25 WD repeat domain 25
WDR78 WD repeat domain 78
WLS wntless Wnt ligand secretion mediator
ZNF136 zinc finger protein 136
ZNF205 zinc finger protein 205
ZNF571 zinc finger protein 571
ZNF768 zinc finger protein 768