2,6-dimethylpiperidine-4543 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the 2,6-dimethylpiperidine-4543 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ACTN2 actinin, alpha 2
ADAM22 ADAM metallopeptidase domain 22
ADGRG1 adhesion G protein-coupled receptor G1
ALDOB aldolase B, fructose-bisphosphate
ARPIN actin-related protein 2/3 complex inhibitor
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BTN3A2 butyrophilin, subfamily 3, member A2
C11ORF1 chromosome 11 open reading frame 1
C20ORF195 chromosome 20 open reading frame 195
CACFD1 calcium channel flower domain containing 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCN6 chloride channel, voltage-sensitive 6
CLDN17 claudin 17
CNN1 calponin 1, basic, smooth muscle
CTNS cystinosin, lysosomal cystine transporter
CYSLTR1 cysteinyl leukotriene receptor 1
DAPK1 death-associated protein kinase 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK6 dedicator of cytokinesis 6
DOHH deoxyhypusine hydroxylase/monooxygenase
E2F4 E2F transcription factor 4, p107/p130-binding
FAXDC2 fatty acid hydroxylase domain containing 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF4 fibroblast growth factor 4
FZD1 frizzled class receptor 1
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLRA1 glycine receptor, alpha 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GREB1L growth regulation by estrogen in breast cancer-like
GSK3A glycogen synthase kinase 3 alpha
GYG2 glycogenin 2
HDAC11 histone deacetylase 11
HOXD11 homeobox D11
ICOS inducible T-cell co-stimulator
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGSF1 immunoglobulin superfamily, member 1
IL1R1 interleukin 1 receptor, type I
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JUND jun D proto-oncogene
KDM4B lysine (K)-specific demethylase 4B
KLF1 Kruppel-like factor 1 (erythroid)
LRP1 low density lipoprotein receptor-related protein 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MLXIP MLX interacting protein
MVB12B multivesicular body subunit 12B
MYH14 myosin, heavy chain 14, non-muscle
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NGF nerve growth factor (beta polypeptide)
NPTX1 neuronal pentraxin I
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OXCT2 3-oxoacid CoA transferase 2
PAPPA2 pappalysin 2
PCDHB17P protocadherin beta 17 pseudogene
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
PTCRA pre T-cell antigen receptor alpha
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
REEP2 receptor accessory protein 2
RGS3 regulator of G-protein signaling 3
RPL10L ribosomal protein L10-like
SBNO2 strawberry notch homolog 2 (Drosophila)
SCARB1 scavenger receptor class B, member 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1A sodium channel, voltage gated, type I alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SH2B1 SH2B adaptor protein 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SRSF1 serine/arginine-rich splicing factor 1
ST7L suppression of tumorigenicity 7 like
SUGP1 SURP and G patch domain containing 1
TAT tyrosine aminotransferase
TLDC1 TBC/LysM-associated domain containing 1
TMPRSS4 transmembrane protease, serine 4
USP29 ubiquitin specific peptidase 29
UTRN utrophin
UTS2 urotensin 2
WT1 Wilms tumor 1
XDH xanthine dehydrogenase
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF268 zinc finger protein 268
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSL4 acyl-CoA synthetase long-chain family member 4
ADCY7 adenylate cyclase 7
ADGRG2 adhesion G protein-coupled receptor G2
AEN apoptosis enhancing nuclease
APOL6 apolipoprotein L, 6
ARL14 ADP-ribosylation factor-like 14
C17ORF85 chromosome 17 open reading frame 85
C22ORF29 chromosome 22 open reading frame 29
C5ORF42 chromosome 5 open reading frame 42
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CENPQ centromere protein Q
CLCN5 chloride channel, voltage-sensitive 5
CPED1 cadherin-like and PC-esterase domain containing 1
CPNE7 copine VII
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
EHD3 EH-domain containing 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERCC2 excision repair cross-complementation group 2
FAM155A family with sequence similarity 155, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGD1 FYVE, RhoGEF and PH domain containing 1
GAS8 growth arrest-specific 8
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDAC9 histone deacetylase 9
HIRIP3 HIRA interacting protein 3
HIST1H3A histone cluster 1, H3a
HIST1H3G histone cluster 1, H3g
HOXA4 homeobox A4
IGSF3 immunoglobulin superfamily, member 3
ITPKA inositol-trisphosphate 3-kinase A
KIRREL kin of IRRE like (Drosophila)
KLF3 Kruppel-like factor 3 (basic)
KLHL36 kelch-like family member 36
KRT6A keratin 6A, type II
KRT8P12 keratin 8 pseudogene 12
LNPEP leucyl/cystinyl aminopeptidase
LRRK1 leucine-rich repeat kinase 1
LYPLA2P1 lysophospholipase II pseudogene 1
MAGEF1 melanoma antigen family F1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD6 major facilitator superfamily domain containing 6
MNX1 motor neuron and pancreas homeobox 1
MON1B MON1 secretory trafficking family member B
MOXD1 monooxygenase, DBH-like 1
MT1M metallothionein 1M
MTA2 metastasis associated 1 family, member 2
MTERF4 mitochondrial transcription termination factor 4
MUC3B mucin 3B, cell surface associated
MYO1D myosin ID
NCS1 neuronal calcium sensor 1
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PARM1 prostate androgen-regulated mucin-like protein 1
PDE12 phosphodiesterase 12
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLL polymerase (DNA directed), lambda
PPCDC phosphopantothenoylcysteine decarboxylase
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKX protein kinase, X-linked
PRSS8 protease, serine, 8
RABL6 RAB, member RAS oncogene family-like 6
RGS17 regulator of G-protein signaling 17
RHOBTB2 Rho-related BTB domain containing 2
RUNX1-IT1 RUNX1 intronic transcript 1
SAMD9 sterile alpha motif domain containing 9
SCG5 secretogranin V
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETBP1 SET binding protein 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SOBP sine oculis binding protein homolog (Drosophila)
SPEG SPEG complex locus
SYNGR3 synaptogyrin 3
THBS3 thrombospondin 3
TNRC6B trinucleotide repeat containing 6B
TPST2 tyrosylprotein sulfotransferase 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBA3C tubulin, alpha 3c
VASH1 vasohibin 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZFP30 ZFP30 zinc finger protein
ZHX2 zinc fingers and homeoboxes 2
ZNF37BP zinc finger protein 37B, pseudogene
ZNF510 zinc finger protein 510
ZNF623 zinc finger protein 623
ZNF667 zinc finger protein 667
ZNF862 zinc finger protein 862