2,6-dimethylpiperidine-3889 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the 2,6-dimethylpiperidine-3889 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACRV1 acrosomal vesicle protein 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAP2 ArfGAP with dual PH domains 2
ARL3 ADP-ribosylation factor-like 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCAN brevican
BIRC3 baculoviral IAP repeat containing 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C10ORF12 chromosome 10 open reading frame 12
C3ORF18 chromosome 3 open reading frame 18
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD4 CD4 molecule
CDRT1 CMT1A duplicated region transcript 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CNTN1 contactin 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DGCR8 DGCR8 microprocessor complex subunit
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DRD2 dopamine receptor D2
DYM dymeclin
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EPHA5 EPH receptor A5
ERN1 endoplasmic reticulum to nucleus signaling 1
FCMR Fc fragment of IgM receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF21 fibroblast growth factor 21
FKBP6 FK506 binding protein 6, 36kDa
GGT1 gamma-glutamyltransferase 1
GPR137 G protein-coupled receptor 137
GRIK5 glutamate receptor, ionotropic, kainate 5
HAUS5 HAUS augmin-like complex, subunit 5
HERC2P3 hect domain and RLD 2 pseudogene 3
HIST1H3B histone cluster 1, H3b
HMGN5 high mobility group nucleosome binding domain 5
HPX hemopexin
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IGHA1 immunoglobulin heavy constant alpha 1
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IZUMO4 IZUMO family member 4
KANK1 KN motif and ankyrin repeat domains 1
KDM4B lysine (K)-specific demethylase 4B
KHSRP KH-type splicing regulatory protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LIMK1 LIM domain kinase 1
LIMS2 LIM and senescent cell antigen-like domains 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP13 matrix metallopeptidase 13
MN1 meningioma (disrupted in balanced translocation) 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1R macrophage stimulating 1 receptor
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NECAB2 N-terminal EF-hand calcium binding protein 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGA3 protocadherin gamma subfamily A, 3
PDLIM5 PDZ and LIM domain 5
PHF20L1 PHD finger protein 20-like 1
PLCH1 phospholipase C, eta 1
PLK3 polo-like kinase 3
PPARD peroxisome proliferator-activated receptor delta
PRX periaxin
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REC8 REC8 meiotic recombination protein
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF126P1 ring finger protein 126 pseudogene 1
RPH3A rabphilin 3A
RPL10L ribosomal protein L10-like
RPL7 ribosomal protein L7
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFTPB surfactant protein B
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SPRR3 small proline-rich protein 3
STAT4 signal transducer and activator of transcription 4
STEAP4 STEAP family member 4
TCF3 transcription factor 3
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TDRKH tudor and KH domain containing
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53I11 tumor protein p53 inducible protein 11
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIO trio Rho guanine nucleotide exchange factor
VN1R1 vomeronasal 1 receptor 1
ZMAT4 zinc finger, matrin-type 4
ZNF197 zinc finger protein 197
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADTRP androgen-dependent TFPI-regulating protein
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC4 armadillo repeat containing 4
BAGE B melanoma antigen
C17ORF80 chromosome 17 open reading frame 80
C5AR1 complement component 5a receptor 1
CCDC64 coiled-coil domain containing 64
CCDC71 coiled-coil domain containing 71
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK6 cyclin-dependent kinase 6
CDKN2AIP CDKN2A interacting protein
CEMIP cell migration inducing protein, hyaluronan binding
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CSF1R colony stimulating factor 1 receptor
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK4 dedicator of cytokinesis 4
DRD1 dopamine receptor D1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC2 excision repair cross-complementation group 2
FAM46C family with sequence similarity 46, member C
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR176 G protein-coupled receptor 176
GTF2I general transcription factor IIi
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HIST1H4F histone cluster 1, H4f
HMOX1 heme oxygenase 1
HOXC4 homeobox C4
HP1BP3 heterochromatin protein 1, binding protein 3
IDI2-AS1 IDI2 antisense RNA 1
IL12RB1 interleukin 12 receptor, beta 1
IL22 interleukin 22
IQCG IQ motif containing G
KCTD20 potassium channel tetramerization domain containing 20
KRT15 keratin 15, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIF leukemia inhibitory factor
LMAN1 lectin, mannose-binding, 1
LOC390998 ribosomal protein L10 pseudogene
MCOLN1 mucolipin 1
METTL16 methyltransferase like 16
MFGE8 milk fat globule-EGF factor 8 protein
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NT5E 5'-nucleotidase, ecto (CD73)
ONECUT2 one cut homeobox 2
PARD6A par-6 family cell polarity regulator alpha
PCDHGA8 protocadherin gamma subfamily A, 8
PDIA3 protein disulfide isomerase family A, member 3
PEX26 peroxisomal biogenesis factor 26
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PMCH pro-melanin-concentrating hormone
PODNL1 podocan-like 1
QPCT glutaminyl-peptide cyclotransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFXAP regulatory factor X-associated protein
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RRAGB Ras-related GTP binding B
SCARA3 scavenger receptor class A, member 3
SCD5 stearoyl-CoA desaturase 5
SIX1 SIX homeobox 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPRYD7 SPRY domain containing 7
SREK1IP1 SREK1-interacting protein 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYNC syncoilin, intermediate filament protein
TADA2A transcriptional adaptor 2A
TEP1 telomerase-associated protein 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM209 transmembrane protein 209
TMEM53 transmembrane protein 53
TNS2 tensin 2
TWISTNB TWIST neighbor
UPK3B uroplakin 3B
WDR76 WD repeat domain 76
ZBTB6 zinc finger and BTB domain containing 6
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF134 zinc finger protein 134
ZNF286A zinc finger protein 286A
ZNF423 zinc finger protein 423
ZNF480 zinc finger protein 480