2,6-dimethylpiperidine-3806 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the 2,6-dimethylpiperidine-3806 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AKR1C1 aldo-keto reductase family 1, member C1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANTXR1 anthrax toxin receptor 1
ARHGAP44 Rho GTPase activating protein 44
ATXN3 ataxin 3
BAIAP3 BAI1-associated protein 3
BMP1 bone morphogenetic protein 1
C10ORF12 chromosome 10 open reading frame 12
C17ORF59 chromosome 17 open reading frame 59
C7 complement component 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDO1 cysteine dioxygenase type 1
CFAP70 cilia and flagella associated protein 70
CHI3L2 chitinase 3-like 2
CNTN1 contactin 1
CPB2 carboxypeptidase B2 (plasma)
CRAT carnitine O-acetyltransferase
CTSS cathepsin S
CXCR4 chemokine (C-X-C motif) receptor 4
CXORF21 chromosome X open reading frame 21
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DMPK dystrophia myotonica-protein kinase
DPYSL4 dihydropyrimidinase-like 4
DRD2 dopamine receptor D2
EFR3B EFR3 homolog B (S. cerevisiae)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EXOSC1 exosome component 1
FAIM2 Fas apoptotic inhibitory molecule 2
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GLRA1 glycine receptor, alpha 1
GP5 glycoprotein V (platelet)
GRIP2 glutamate receptor interacting protein 2
GYPB glycophorin B (MNS blood group)
HDAC6 histone deacetylase 6
HFE hemochromatosis
HPX hemopexin
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IL15 interleukin 15
IL32 interleukin 32
IRX5 iroquois homeobox 5
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA1456 KIAA1456
KLRC3 killer cell lectin-like receptor subfamily C, member 3
LAMA4 laminin, alpha 4
LAMB4 laminin, beta 4
LTBP4 latent transforming growth factor beta binding protein 4
MED25 mediator complex subunit 25
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MTNR1A melatonin receptor 1A
MUC3B mucin 3B, cell surface associated
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NT5M 5',3'-nucleotidase, mitochondrial
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PCDHB1 protocadherin beta 1
PDE5A phosphodiesterase 5A, cGMP-specific
PDLIM5 PDZ and LIM domain 5
PGAP3 post-GPI attachment to proteins 3
PHOX2B paired-like homeobox 2b
PKNOX1 PBX/knotted 1 homeobox 1
PLCH2 phospholipase C, eta 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKCB protein kinase C, beta
RAB40A RAB40A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REC8 REC8 meiotic recombination protein
REG1A regenerating islet-derived 1 alpha
RIMS3 regulating synaptic membrane exocytosis 3
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLN sarcolipin
SPTBN5 spectrin, beta, non-erythrocytic 5
SRSF5 serine/arginine-rich splicing factor 5
SULT4A1 sulfotransferase family 4A, member 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TDRD12 tudor domain containing 12
TGFB1 transforming growth factor, beta 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TRAPPC9 trafficking protein particle complex 9
TTC12 tetratricopeptide repeat domain 12
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VSX1 visual system homeobox 1
WNT3 wingless-type MMTV integration site family, member 3
XYLT1 xylosyltransferase I
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF3 zinc finger protein 3
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACOX2 acyl-CoA oxidase 2, branched chain
ACSS3 acyl-CoA synthetase short-chain family member 3
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAP2 ArfGAP with dual PH domains 2
ANXA10 annexin A10
APH1B APH1B gamma secretase subunit
APOL6 apolipoprotein L, 6
ARMCX4 armadillo repeat containing, X-linked 4
ART1 ADP-ribosyltransferase 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BICC1 BicC family RNA binding protein 1
C7ORF43 chromosome 7 open reading frame 43
CCDC186 coiled-coil domain containing 186
CCNK cyclin K
CCNO cyclin O
CDIP1 cell death-inducing p53 target 1
CLDN1 claudin 1
COPZ2 coatomer protein complex, subunit zeta 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPZ carboxypeptidase Z
CRELD1 cysteine-rich with EGF-like domains 1
CRMP1 collapsin response mediator protein 1
CTC1 CTS telomere maintenance complex component 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DIO3 deiodinase, iodothyronine, type III
DOK5 docking protein 5
DSPP dentin sialophosphoprotein
ELAC1 elaC ribonuclease Z 1
EPN1 epsin 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO31 F-box protein 31
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR21 G protein-coupled receptor 21
GPR3 G protein-coupled receptor 3
GRTP1 growth hormone regulated TBC protein 1
HDAC11 histone deacetylase 11
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA6 homeobox A6
IFI6 interferon, alpha-inducible protein 6
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF13 Kruppel-like factor 13
KRT31 keratin 31, type I
LAMC3 laminin, gamma 3
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIMD2 LIM domain containing 2
LRRC15 leucine rich repeat containing 15
LYRM9 LYR motif containing 9
MMP13 matrix metallopeptidase 13
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NAT6 N-acetyltransferase 6 (GCN5-related)
NLGN1 neuroligin 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NR1H4 nuclear receptor subfamily 1, group H, member 4
OGDHL oxoglutarate dehydrogenase-like
OLFML2B olfactomedin-like 2B
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAQR6 progestin and adipoQ receptor family member VI
PGPEP1 pyroglutamyl-peptidase I
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPH peripherin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RABL6 RAB, member RAS oncogene family-like 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASL11B RAS-like, family 11, member B
RGCC regulator of cell cycle
RPL10L ribosomal protein L10-like
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A3 S100 calcium binding protein A3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLAMF7 SLAM family member 7
SLC16A6 solute carrier family 16, member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SPANXC SPANX family, member C
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
TH tyrosine hydroxylase
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN8 tetraspanin 8
WDR78 WD repeat domain 78
ZNF205 zinc finger protein 205
ZNF334 zinc finger protein 334
ZNF385D zinc finger protein 385D
ZNF446 zinc finger protein 446
ZNF629 zinc finger protein 629
ZNF76 zinc finger protein 76