16,16-dimethylprostaglandin E2-6597 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the 16,16-dimethylprostaglandin E2-6597 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARL4C ADP-ribosylation factor-like 4C
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BMP1 bone morphogenetic protein 1
CABIN1 calcineurin binding protein 1
CD82 CD82 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLEC11A C-type lectin domain family 11, member A
COL6A1 collagen, type VI, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
DGKE diacylglycerol kinase, epsilon 64kDa
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ESRRA estrogen-related receptor alpha
FAM118A family with sequence similarity 118, member A
FBLN1 fibulin 1
FBXW11 F-box and WD repeat domain containing 11
FGFR4 fibroblast growth factor receptor 4
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GOSR2 golgi SNAP receptor complex member 2
GPR87 G protein-coupled receptor 87
HLA-G major histocompatibility complex, class I, G
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXD11 homeobox D11
HYI hydroxypyruvate isomerase (putative)
IL4R interleukin 4 receptor
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LIG3 ligase III, DNA, ATP-dependent
LINC00341 long intergenic non-protein coding RNA 341
LRP6 low density lipoprotein receptor-related protein 6
MAPK7 mitogen-activated protein kinase 7
MED22 mediator complex subunit 22
MMP19 matrix metallopeptidase 19
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH14 myosin, heavy chain 14, non-muscle
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCAPH2 non-SMC condensin II complex, subunit H2
NOP16 NOP16 nucleolar protein
NSUN6 NOP2/Sun domain family, member 6
NUP160 nucleoporin 160kDa
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PAPOLG poly(A) polymerase gamma
PAQR3 progestin and adipoQ receptor family member III
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAGL1 pleiomorphic adenoma gene-like 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP4R4 protein phosphatase 4, regulatory subunit 4
PPP5C protein phosphatase 5, catalytic subunit
QKI QKI, KH domain containing, RNA binding
RCAN3 RCAN family member 3
RFTN1 raftlin, lipid raft linker 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL35A ribosomal protein L35a
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEC24A SEC24 family member A
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SENP5 SUMO1/sentrin specific peptidase 5
SH3BP1 SH3-domain binding protein 1
SIRT3 sirtuin 3
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SS18 synovial sarcoma translocation, chromosome 18
SUGP1 SURP and G patch domain containing 1
TCTN1 tectonic family member 1
TMEM161A transmembrane protein 161A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOR4A torsin family 4, member A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR25 WD repeat domain 25
WDR48 WD repeat domain 48
XAB2 XPA binding protein 2
XYLT2 xylosyltransferase II
ZNF205 zinc finger protein 205

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMT aminomethyltransferase
APH1A APH1A gamma secretase subunit
ATG2A autophagy related 2A
BST2 bone marrow stromal cell antigen 2
C16ORF45 chromosome 16 open reading frame 45
C2ORF27A chromosome 2 open reading frame 27A
C5AR1 complement component 5a receptor 1
C5ORF45 chromosome 5 open reading frame 45
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN15 calpain 15
CCP110 centriolar coiled coil protein 110kDa
CD53 CD53 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN2AIP CDKN2A interacting protein
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CFD complement factor D (adipsin)
CLCN2 chloride channel, voltage-sensitive 2
CLCN6 chloride channel, voltage-sensitive 6
CLSPN claspin
CLSTN2 calsyntenin 2
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRISP2 cysteine-rich secretory protein 2
CRLF2 cytokine receptor-like factor 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGKG diacylglycerol kinase, gamma 90kDa
DUSP13 dual specificity phosphatase 13
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELOVL4 ELOVL fatty acid elongase 4
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERI3 ERI1 exoribonuclease family member 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM169A family with sequence similarity 169, member A
GBP2 guanylate binding protein 2, interferon-inducible
GDAP2 ganglioside induced differentiation associated protein 2
GID4 GID complex subunit 4
GSTA4 glutathione S-transferase alpha 4
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HIST2H2AA3 histone cluster 2, H2aa3
IFI6 interferon, alpha-inducible protein 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCTD7 potassium channel tetramerization domain containing 7
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
LIN7A lin-7 homolog A (C. elegans)
LYPD1 LY6/PLAUR domain containing 1
LZTR1 leucine-zipper-like transcription regulator 1
MEFV Mediterranean fever
MUC3B mucin 3B, cell surface associated
MYO19 myosin XIX
NXPE3 neurexophilin and PC-esterase domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PCBP4 poly(rC) binding protein 4
PEX26 peroxisomal biogenesis factor 26
PLEKHA6 pleckstrin homology domain containing, family A member 6
POPDC3 popeye domain containing 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS19 regulator of G-protein signaling 19
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF122 ring finger protein 122
SAYSD1 SAYSVFN motif domain containing 1
SLC12A8 solute carrier family 12, member 8
SLC25A40 solute carrier family 25, member 40
STK16 serine/threonine kinase 16
TEX40 testis expressed 40
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMEM230 transmembrane protein 230
TMLHE trimethyllysine hydroxylase, epsilon
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB38 zinc finger and BTB domain containing 38
ZBTB44 zinc finger and BTB domain containing 44
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMAT5 zinc finger, matrin-type 5
ZNF639 zinc finger protein 639
ZNF701 zinc finger protein 701
ZNF74 zinc finger protein 74
ZNF76 zinc finger protein 76