1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4. (Chemical Entities of Biological Interest Ontology, CHEBI_17963)
External Link http://ctdbase.org/detail.go?type=chem&acc=D015632
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Genes

62 genes/proteins interacting with the chemical 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKT1 v-akt murine thymoma viral oncogene homolog 1
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CYC1 cytochrome c-1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDIT3 DNA-damage-inducible transcript 3
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
GAP43 growth associated protein 43
GDNF glial cell derived neurotrophic factor
GFAP glial fibrillary acidic protein
GPX1 glutathione peroxidase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3B glycogen synthase kinase 3 beta
GSTA4 glutathione S-transferase alpha 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMOX1 heme oxygenase 1
IL1B interleukin 1, beta
IL6 interleukin 6
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MT3 metallothionein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFE2L2 nuclear factor, erythroid 2-like 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
OCLN occludin
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB3A RAB3A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
TFAM transcription factor A, mitochondrial
TH tyrosine hydroxylase
TJP1 tight junction protein 1
TNF tumor necrosis factor
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIP vasoactive intestinal peptide
XBP1 X-box binding protein 1