1,4-chrysenequinone-7139 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the 1,4-chrysenequinone-7139 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AKAP17A A kinase (PRKA) anchor protein 17A
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ATF3 activating transcription factor 3
ATF7IP2 activating transcription factor 7 interacting protein 2
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
C21ORF91 chromosome 21 open reading frame 91
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CLK1 CDC-like kinase 1
CLU clusterin
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
EFNA5 ephrin-A5
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
F11R F11 receptor
FAM46A family with sequence similarity 46, member A
FAM46C family with sequence similarity 46, member C
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H3G histone cluster 1, H3g
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
ISL1 ISL LIM homeobox 1
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGSN lengsin, lens protein with glutamine synthetase domain
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICB MHC class I polypeptide-related sequence B
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MRPL18 mitochondrial ribosomal protein L18
MYLIP myosin regulatory light chain interacting protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF1 nuclear RNA export factor 1
OSR2 odd-skipped related transciption factor 2
PELI1 pellino E3 ubiquitin protein ligase 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND1 Rho family GTPase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SMC4 structural maintenance of chromosomes 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TESPA1 thymocyte expressed, positive selection associated 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM26 tripartite motif containing 26
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
UROD uroporphyrinogen decarboxylase
USPL1 ubiquitin specific peptidase like 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WIZ widely interspaced zinc finger motifs
ZFP36 ZFP36 ring finger protein
ZMYM5 zinc finger, MYM-type 5
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2L2 BCL2-like 2
BHLHE40 basic helix-loop-helix family, member e40
C12ORF29 chromosome 12 open reading frame 29
C9ORF91 chromosome 9 open reading frame 91
CAPRIN2 caprin family member 2
CASD1 CAS1 domain containing 1
CASP8AP2 caspase 8 associated protein 2
CCDC69 coiled-coil domain containing 69
CEP97 centrosomal protein 97kDa
CHMP7 charged multivesicular body protein 7
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLK2 CDC-like kinase 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
DDHD2 DDHD domain containing 2
DENND4B DENN/MADD domain containing 4B
DIXDC1 DIX domain containing 1
DNAAF2 dynein, axonemal, assembly factor 2
DNMBP dynamin binding protein
EDIL3 EGF-like repeats and discoidin I-like domains 3
EML4 echinoderm microtubule associated protein like 4
EXOC2 exocyst complex component 2
FBXO5 F-box protein 5
FOXA1 forkhead box A1
FZD4 frizzled class receptor 4
FZD8 frizzled class receptor 8
GBX2 gastrulation brain homeobox 2
GMPPA GDP-mannose pyrophosphorylase A
GRAMD1B GRAM domain containing 1B
GUSBP3 glucuronidase, beta pseudogene 3
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITPKB inositol-trisphosphate 3-kinase B
KCTD20 potassium channel tetramerization domain containing 20
KIF15 kinesin family member 15
KIF16B kinesin family member 16B
KLHL12 kelch-like family member 12
KLHL9 kelch-like family member 9
LOC100272216 uncharacterized LOC100272216
LPAR6 lysophosphatidic acid receptor 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MFSD12 major facilitator superfamily domain containing 12
MKL2 MKL/myocardin-like 2
MNT MAX network transcriptional repressor
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NINL ninein-like
NLK nemo-like kinase
NSD1 nuclear receptor binding SET domain protein 1
NUBPL nucleotide binding protein-like
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PANK4 pantothenate kinase 4
PARP16 poly (ADP-ribose) polymerase family, member 16
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRMT7 protein arginine methyltransferase 7
PTK7 protein tyrosine kinase 7 (inactive)
REV1 REV1, polymerase (DNA directed)
RNF44 ring finger protein 44
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCML2 sex comb on midleg-like 2 (Drosophila)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STARD13 StAR-related lipid transfer (START) domain containing 13
STK25 serine/threonine kinase 25
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D16 TBC1 domain family, member 16
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRAF5 TNF receptor-associated factor 5
TRIM13 tripartite motif containing 13
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TULP4 tubby like protein 4
UBL4A ubiquitin-like 4A
UNC13B unc-13 homolog B (C. elegans)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VANGL1 VANGL planar cell polarity protein 1
WASF1 WAS protein family, member 1
WDR37 WD repeat domain 37
WDR76 WD repeat domain 76
ZBED8 zinc finger, BED-type containing 8
ZC3H4 zinc finger CCCH-type containing 4
ZNF217 zinc finger protein 217
ZNF451 zinc finger protein 451