(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. (Chemical Entities of Biological Interest Ontology, CHEBI_78510)
External Link http://ctdbase.org/detail.go?type=chem&acc=C516138
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Genes

70 genes/proteins interacting with the chemical (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
APP amyloid beta (A4) precursor protein
ARG1 arginase 1
ATM ATM serine/threonine kinase
BAX BCL2-associated X protein
BCL2L1 BCL2-like 1
CAMP cathelicidin antimicrobial peptide
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CCNB1 cyclin B1
CD36 CD36 molecule (thrombospondin receptor)
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK2 checkpoint kinase 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CPT1B carnitine palmitoyltransferase 1B (muscle)
CREB1 cAMP responsive element binding protein 1
CYBA cytochrome b-245, alpha polypeptide
DGAT2 diacylglycerol O-acyltransferase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
FAS Fas cell surface death receptor
FASN fatty acid synthase
FOXO1 forkhead box O1
GCLC glutamate-cysteine ligase, catalytic subunit
GDF2 growth differentiation factor 2
GSK3B glycogen synthase kinase 3 beta
GSTK1 glutathione S-transferase kappa 1
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
IL10 interleukin 10
IL1B interleukin 1, beta
IL6 interleukin 6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
PARP1 poly (ADP-ribose) polymerase 1
PLAT plasminogen activator, tissue
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
SMAD9 SMAD family member 9
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SREBF1 sterol regulatory element binding transcription factor 1
STK11 serine/threonine kinase 11
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53