(-)-isoprenaline-6149 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the (-)-isoprenaline-6149 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANGPTL2 angiopoietin-like 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
BAIAP2 BAI1-associated protein 2
BIN1 bridging integrator 1
BMP6 bone morphogenetic protein 6
C11ORF16 chromosome 11 open reading frame 16
C1QA complement component 1, q subcomponent, A chain
CCL20 chemokine (C-C motif) ligand 20
CCL22 chemokine (C-C motif) ligand 22
CD86 CD86 molecule
CHN2 chimerin 2
COL4A2 collagen, type IV, alpha 2
CPNE3 copine III
CREM cAMP responsive element modulator
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOCK4 dedicator of cytokinesis 4
DPEP2 dipeptidase 2
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS3 fatty acid desaturase 3
FAM13A family with sequence similarity 13, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FPR1 formyl peptide receptor 1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPC1 glypican 1
GPR183 G protein-coupled receptor 183
GRAMD1B GRAM domain containing 1B
HIST1H2BJ histone cluster 1, H2bj
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IL16 interleukin 16
IL1R1 interleukin 1 receptor, type I
ING4 inhibitor of growth family, member 4
INHBA inhibin, beta A
IQSEC1 IQ motif and Sec7 domain 1
ISG20 interferon stimulated exonuclease gene 20kDa
KYNU kynureninase
LAMB3 laminin, beta 3
MAU2 MAU2 sister chromatid cohesion factor
MCAM melanoma cell adhesion molecule
MOB3B MOB kinase activator 3B
MTUS1 microtubule associated tumor suppressor 1
MXD4 MAX dimerization protein 4
MXRA8 matrix-remodelling associated 8
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR1 phospholipid scramblase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKCE protein kinase C, epsilon
PRODH2 proline dehydrogenase (oxidase) 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
REC8 REC8 meiotic recombination protein
SAG S-antigen; retina and pineal gland (arrestin)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SSH1 slingshot protein phosphatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TREM2 triggering receptor expressed on myeloid cells 2
TXK TXK tyrosine kinase
UCN urocortin
ZBTB20 zinc finger and BTB domain containing 20
ZER1 zyg-11 related, cell cycle regulator

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ALG3 ALG3, alpha-1,3- mannosyltransferase
ANKRD55 ankyrin repeat domain 55
ARRB1 arrestin, beta 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD3A ATPase family, AAA domain containing 3A
C11ORF21 chromosome 11 open reading frame 21
C12ORF29 chromosome 12 open reading frame 29
CA2 carbonic anhydrase II
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBS cystathionine-beta-synthase
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CTSG cathepsin G
CUX2 cut-like homeobox 2
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOK3 docking protein 3
EBNA1BP2 EBNA1 binding protein 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EXOSC5 exosome component 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM53B family with sequence similarity 53, member B
FAM57A family with sequence similarity 57, member A
FAM86B1 family with sequence similarity 86, member B1
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FJX1 four jointed box 1 (Drosophila)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IFRD2 interferon-related developmental regulator 2
KIAA0020 KIAA0020
KIF17 kinesin family member 17
KIF21B kinesin family member 21B
METRN meteorin, glial cell differentiation regulator
METTL8 methyltransferase like 8
MRPL4 mitochondrial ribosomal protein L4
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NPIPB3 nuclear pore complex interacting protein family, member B3
NTHL1 nth endonuclease III-like 1 (E. coli)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDCD11 programmed cell death 11
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PSAT1 phosphoserine aminotransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RARS arginyl-tRNA synthetase
RETN resistin
RPIA ribose 5-phosphate isomerase A
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUVBL1 RuvB-like AAA ATPase 1
SALL2 spalt-like transcription factor 2
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNHG3 small nucleolar RNA host gene 3
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
STEAP3 STEAP family member 3, metalloreductase
STRA13 stimulated by retinoic acid 13
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAS2R10 taste receptor, type 2, member 10
TGFBR1 transforming growth factor, beta receptor 1
TICAM1 toll-like receptor adaptor molecule 1
TRHDE thyrotropin-releasing hormone degrading enzyme
TTC26 tetratricopeptide repeat domain 26
TTC27 tetratricopeptide repeat domain 27
UPB1 ureidopropionase, beta
UPK3A uroplakin 3A
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VSIG4 V-set and immunoglobulin domain containing 4
WASF3 WAS protein family, member 3
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR46 WD repeat domain 46
XBP1 X-box binding protein 1
ZNF667 zinc finger protein 667