(-)-MK-801-6657 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the (-)-MK-801-6657 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1D adrenoceptor alpha 1D
AKR1C2 aldo-keto reductase family 1, member C2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMPH amphiphysin
AOAH acyloxyacyl hydrolase (neutrophil)
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP9B ATPase, class II, type 9B
BAIAP3 BAI1-associated protein 3
BAZ1B bromodomain adjacent to zinc finger domain, 1B
CADM4 cell adhesion molecule 4
CALD1 caldesmon 1
CCR7 chemokine (C-C motif) receptor 7
CD248 CD248 molecule, endosialin
CIB2 calcium and integrin binding family member 2
CLTCL1 clathrin, heavy chain-like 1
CRTC1 CREB regulated transcription coactivator 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSZ cathepsin Z
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DBF4B DBF4 zinc finger B
EDN1 endothelin 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERN1 endoplasmic reticulum to nucleus signaling 1
ETV1 ets variant 1
ETV6 ets variant 6
FGB fibrinogen beta chain
FLOT1 flotillin 1
FOXO4 forkhead box O4
FRMD4B FERM domain containing 4B
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FZD10 frizzled class receptor 10
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR135 G protein-coupled receptor 135
GREB1L growth regulation by estrogen in breast cancer-like
HABP2 hyaluronan binding protein 2
HCFC1 host cell factor C1
HGD homogentisate 1,2-dioxygenase
HNRNPM heterogeneous nuclear ribonucleoprotein M
HRASLS2 HRAS-like suppressor 2
ING4 inhibitor of growth family, member 4
INHA inhibin, alpha
KDM4C lysine (K)-specific demethylase 4C
KIF1C kinesin family member 1C
KLHL22 kelch-like family member 22
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LOX lysyl oxidase
MCF2L MCF.2 cell line derived transforming sequence-like
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NBEAL2 neurobeachin-like 2
NOX1 NADPH oxidase 1
PBOV1 prostate and breast cancer overexpressed 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G5 phospholipase A2, group V
POLL polymerase (DNA directed), lambda
PON1 paraoxonase 1
POU6F1 POU class 6 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTN pleiotrophin
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RAX retina and anterior neural fold homeobox
RBBP9 retinoblastoma binding protein 9
REC8 REC8 meiotic recombination protein
RGS12 regulator of G-protein signaling 12
RIMBP2 RIMS binding protein 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SCG3 secretogranin III
SCN2A sodium channel, voltage gated, type II alpha subunit
SH3GL3 SH3-domain GRB2-like 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
STAB2 stabilin 2
STK24 serine/threonine kinase 24
SUSD5 sushi domain containing 5
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TGFB2 transforming growth factor, beta 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNRD2 thioredoxin reductase 2
TXNRD3 thioredoxin reductase 3
TYMP thymidine phosphorylase
VAMP5 vesicle-associated membrane protein 5
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF334 zinc finger protein 334

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
AFAP1 actin filament associated protein 1
ALPK1 alpha-kinase 1
ANXA10 annexin A10
ANXA2P1 annexin A2 pseudogene 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATAD5 ATPase family, AAA domain containing 5
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCAS4 breast carcinoma amplified sequence 4
BCCIP BRCA2 and CDKN1A interacting protein
CCDC106 coiled-coil domain containing 106
CCDC132 coiled-coil domain containing 132
CCDC88C coiled-coil domain containing 88C
CD82 CD82 molecule
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNTNAP3B contactin associated protein-like 3B
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL3 chemokine (C-X-C motif) ligand 3
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLK2 delta-like 2 homolog (Drosophila)
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
GALK1 galactokinase 1
GEMIN8 gem (nuclear organelle) associated protein 8
GLS2 glutaminase 2 (liver, mitochondrial)
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIST1H3A histone cluster 1, H3a
HLA-DMB major histocompatibility complex, class II, DM beta
HOOK1 hook microtubule-tethering protein 1
HOXC8 homeobox C8
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA14 interferon, alpha 14
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IPO8 importin 8
KIAA1456 KIAA1456
KLF3 Kruppel-like factor 3 (basic)
KRT37 keratin 37, type I
LOC257152 uncharacterized LOC257152
LRP3 low density lipoprotein receptor-related protein 3
LYPD1 LY6/PLAUR domain containing 1
MB myoglobin
MED31 mediator complex subunit 31
MEFV Mediterranean fever
MFGE8 milk fat globule-EGF factor 8 protein
MNS1 meiosis-specific nuclear structural 1
MYL5 myosin, light chain 5, regulatory
NEK11 NIMA-related kinase 11
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
OTUD3 OTU deubiquitinase 3
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPT2 palmitoyl-protein thioesterase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR7 proline rich 7 (synaptic)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PWAR5 Prader Willi/Angelman region RNA 5
RAB3A RAB3A, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
RPH3A rabphilin 3A
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK2 serum/glucocorticoid regulated kinase 2
SKI SKI proto-oncogene
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
THBS3 thrombospondin 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TM6SF1 transmembrane 6 superfamily member 1
TMEM121 transmembrane protein 121
TMSB15A thymosin beta 15a
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRIM21 tripartite motif containing 21
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTN titin
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF222 zinc finger protein 222
ZNF480 zinc finger protein 480
ZNF528 zinc finger protein 528
ZNF667 zinc finger protein 667
ZNF675 zinc finger protein 675