(-)-MK-801-6458 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the (-)-MK-801-6458 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
ALOXE3 arachidonate lipoxygenase 3
ALPPL2 alkaline phosphatase, placental-like 2
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARNT aryl hydrocarbon receptor nuclear translocator
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATXN8OS ATXN8 opposite strand (non-protein coding)
BANK1 B-cell scaffold protein with ankyrin repeats 1
C11ORF30 chromosome 11 open reading frame 30
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC71 coiled-coil domain containing 71
CCPG1 cell cycle progression 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CES3 carboxylesterase 3
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLGN calmegin
CNGB1 cyclic nucleotide gated channel beta 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DFNB31 deafness, autosomal recessive 31
DICER1 dicer 1, ribonuclease type III
DKFZP434L187 uncharacterized LOC26082
EHD1 EH-domain containing 1
EPX eosinophil peroxidase
ESR1 estrogen receptor 1
FETUB fetuin B
FYB FYN binding protein
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAS6 growth arrest-specific 6
GIF gastric intrinsic factor (vitamin B synthesis)
GLP1R glucagon-like peptide 1 receptor
GPR135 G protein-coupled receptor 135
GPR137 G protein-coupled receptor 137
HCRP1 hepatocellular carcinoma-related HCRP1
HHAT hedgehog acyltransferase
HOMER3 homer scaffolding protein 3
HOXB5 homeobox B5
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IHH indian hedgehog
INADL InaD-like (Drosophila)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLHL11 kelch-like family member 11
KLHL23 kelch-like family member 23
KLK2 kallikrein-related peptidase 2
LAMC2 laminin, gamma 2
LRP12 low density lipoprotein receptor-related protein 12
MAGEA5 melanoma antigen family A5
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MMP11 matrix metallopeptidase 11
MSI1 musashi RNA-binding protein 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK myosin light chain kinase
NEBL nebulette
NEFM neurofilament, medium polypeptide
OPCML opioid binding protein/cell adhesion molecule-like
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSGIN1 oxidative stress induced growth inhibitor 1
PARVA parvin, alpha
PCDH1 protocadherin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE8B phosphodiesterase 8B
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD1 phospholipase D1, phosphatidylcholine-specific
PPP1R37 protein phosphatase 1, regulatory subunit 37
PQLC2 PQ loop repeat containing 2
PRKCA protein kinase C, alpha
PTBP3 polypyrimidine tract binding protein 3
PTCH1 patched 1
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF6 ring finger protein (C3H2C3 type) 6
RORC RAR-related orphan receptor C
SCN10A sodium channel, voltage gated, type X alpha subunit
SMAD1 SMAD family member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
TAS2R10 taste receptor, type 2, member 10
TCP11L1 t-complex 11, testis-specific-like 1
TEX13B testis expressed 13B
TMEM40 transmembrane protein 40
TMEM63A transmembrane protein 63A
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TRIO trio Rho guanine nucleotide exchange factor
TRPC6 transient receptor potential cation channel, subfamily C, member 6
YY2 YY2 transcription factor
ZNF606 zinc finger protein 606
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABLIM3 actin binding LIM protein family, member 3
ALOX15 arachidonate 15-lipoxygenase
ALS2CL ALS2 C-terminal like
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARC activity-regulated cytoskeleton-associated protein
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ASPN asporin
ATXN2 ataxin 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAIAP3 BAI1-associated protein 3
BATF basic leucine zipper transcription factor, ATF-like
BCL2L2 BCL2-like 2
BCOR BCL6 corepressor
C5AR2 complement component 5a receptor 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CLCN6 chloride channel, voltage-sensitive 6
CLIC2 chloride intracellular channel 2
CLSPN claspin
CRIP1 cysteine-rich protein 1 (intestinal)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOK5 docking protein 5
EFNA3 ephrin-A3
GALK1 galactokinase 1
GBP2 guanylate binding protein 2, interferon-inducible
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GRPR gastrin-releasing peptide receptor
GSTA4 glutathione S-transferase alpha 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2AK histone cluster 1, H2ak
HIST1H3I histone cluster 1, H3i
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC4 homeobox C4
HOXC5 homeobox C5
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
HYI hydroxypyruvate isomerase (putative)
IL12RB1 interleukin 12 receptor, beta 1
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
IPO8 importin 8
KIAA0894 KIAA0894 protein
LIME1 Lck interacting transmembrane adaptor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC61 leucine rich repeat containing 61
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRPL44 mitochondrial ribosomal protein L44
NCS1 neuronal calcium sensor 1
NELL2 NEL-like 2 (chicken)
NRSN2 neurensin 2
NUP62CL nucleoporin 62kDa C-terminal like
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PC pyruvate carboxylase
PCBP4 poly(rC) binding protein 4
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLL polymerase (DNA directed), lambda
PROL1 proline rich, lacrimal 1
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SFRP5 secreted frizzled-related protein 5
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIRT2 sirtuin 2
SLC17A2 solute carrier family 17, member 2
SLC25A40 solute carrier family 25, member 40
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX12 SRY (sex determining region Y)-box 12
SPINK5 serine peptidase inhibitor, Kazal type 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNC syncoilin, intermediate filament protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN1 tectonic family member 1
TMC7 transmembrane channel-like 7
TMCC2 transmembrane and coiled-coil domain family 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS4 transmembrane protease, serine 4
TTC4 tetratricopeptide repeat domain 4
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR62 WD repeat domain 62
ZNF204P zinc finger protein 204, pseudogene
ZNF37BP zinc finger protein 37B, pseudogene
ZNF586 zinc finger protein 586
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768