(+)-chelidonine-6236 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the (+)-chelidonine-6236 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADCY6 adenylate cyclase 6
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARHGAP33 Rho GTPase activating protein 33
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEP350 centrosomal protein 350kDa
COPS7B COP9 signalosome subunit 7B
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DZIP3 DAZ interacting zinc finger protein 3
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FBXL18 F-box and leucine-rich repeat protein 18
FECH ferrochelatase
FSCN1 fascin actin-bundling protein 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GPC3 glypican 3
HEG1 heart development protein with EGF-like domains 1
HIPK2 homeodomain interacting protein kinase 2
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRF9 interferon regulatory factor 9
ITSN1 intersectin 1 (SH3 domain protein)
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0513 KIAA0513
KIF25-AS1 KIF25 antisense RNA 1
KLF6 Kruppel-like factor 6
KRIT1 KRIT1, ankyrin repeat containing
KRT17 keratin 17, type I
LPP LIM domain containing preferred translocation partner in lipoma
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED13L mediator complex subunit 13-like
MEFV Mediterranean fever
MGLL monoglyceride lipase
MTCL1 microtubule crosslinking factor 1
MTERF4 mitochondrial transcription termination factor 4
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYOF myoferlin
NCKAP1 NCK-associated protein 1
NEB nebulin
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
OGFR opioid growth factor receptor
OSMR oncostatin M receptor
PALLD palladin, cytoskeletal associated protein
PCIF1 PDX1 C-terminal inhibiting factor 1
PDGFA platelet-derived growth factor alpha polypeptide
PLCH1 phospholipase C, eta 1
PLXNA1 plexin A1
PODXL2 podocalyxin-like 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RFTN1 raftlin, lipid raft linker 1
RUNX1 runt-related transcription factor 1
SALL2 spalt-like transcription factor 2
SAPCD1 suppressor APC domain containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGSM2 small G protein signaling modulator 2
SLC35E2 solute carrier family 35, member E2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPAG8 sperm associated antigen 8
STRN3 striatin, calmodulin binding protein 3
TANK TRAF family member-associated NFKB activator
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP3A topoisomerase (DNA) III alpha
TRIO trio Rho guanine nucleotide exchange factor
TUFT1 tuftelin 1
USP27X ubiquitin specific peptidase 27, X-linked
VDAC3 voltage-dependent anion channel 3
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF419 zinc finger protein 419
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGO1 argonaute RISC catalytic component 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
C22ORF29 chromosome 22 open reading frame 29
C2ORF44 chromosome 2 open reading frame 44
C4ORF29 chromosome 4 open reading frame 29
CCDC88C coiled-coil domain containing 88C
CFD complement factor D (adipsin)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CLCN2 chloride channel, voltage-sensitive 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRABP1 cellular retinoic acid binding protein 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EAF2 ELL associated factor 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM63A family with sequence similarity 63, member A
GDAP1 ganglioside induced differentiation associated protein 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLI3 GLI family zinc finger 3
GNL1 guanine nucleotide binding protein-like 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H1E histone cluster 1, H1e
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0125 KIAA0125
KLHL26 kelch-like family member 26
KLK5 kallikrein-related peptidase 5
KRT8P12 keratin 8 pseudogene 12
LINC00115 long intergenic non-protein coding RNA 115
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
LRRC20 leucine rich repeat containing 20
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED24 mediator complex subunit 24
MITF microphthalmia-associated transcription factor
MOCS3 molybdenum cofactor synthesis 3
MOSPD3 motile sperm domain containing 3
NECAP2 NECAP endocytosis associated 2
NPY5R neuropeptide Y receptor Y5
ONECUT2 one cut homeobox 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARP16 poly (ADP-ribose) polymerase family, member 16
PHACTR4 phosphatase and actin regulator 4
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PPL periplakin
PRR15L proline rich 15-like
PRR3 proline rich 3
PRSS8 protease, serine, 8
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB23 RAB23, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RIPK4 receptor-interacting serine-threonine kinase 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCAI suppressor of cancer cell invasion
SESN1 sestrin 1
SLC16A6 solute carrier family 16, member 6
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SNHG20 small nucleolar RNA host gene 20
SREK1IP1 SREK1-interacting protein 1
STAG3 stromal antigen 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIM25 tripartite motif containing 25
TRIM45 tripartite motif containing 45
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBQLN4 ubiquilin 4
UNC13B unc-13 homolog B (C. elegans)
USP18 ubiquitin specific peptidase 18
WDR7 WD repeat domain 7
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFP30 ZFP30 zinc finger protein
ZNF160 zinc finger protein 160
ZNF211 zinc finger protein 211
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675
ZNF721 zinc finger protein 721
ZNF787 zinc finger protein 787