|HGNC Family||Non-coding RNAs|
|Name||RNA, Ro-associated Y1|
|Description||Y RNAs are small noncoding RNAs that were originally identified as the RNA component of soluble ribonucleoproteins (RNPs) termed Ro RNPs. Ro RNPs are detected by autoimmune sera of patients suffering from rheumatic diseases, such as from systemic lupus erythematosus (MIM 152700) and Sjogren syndrome (MIM 270200). Ro RNPs consist of a Y RNA that is associated with the autoimmune antigen proteins Ro60 (TROVE2; MIM 600063) and La (SSB; MIM 109090), as well as other proteins. Four human Y RNAs have been identified: Y1, Y3 (RNY3; MIM 601822), Y4 (RNY4; MIM 601823), and Y5 (RNY5; MIM 601824). (Y2 is a truncated form of Y1.) Y RNAs are transcribed by RNA polymerase III and range in size from 83 to 112 nucleotides. They appear to have a functional role in chromosomal DNA replication (Christov et al., 2006 [PubMed 16943439]).[supplied by OMIM, Apr 2009]|
|NCBI Gene ID||6084|
|Expression in Tissues and Cell Lines||
RNY1 has 109 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 4 datasets.
Click the + buttons to view associations for RNY1 from the datasets below.
If available, associations are ranked by standardized value
|GEO Signatures of Differentially Expressed Genes for Small Molecules||small molecule perturbations changing expression of RNY1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.|
|GTEx Tissue Gene Expression Profiles||tissues with high or low expression of RNY1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.|
|Hub Proteins Protein-Protein Interactions||interacting hub proteins for RNY1 from the curated Hub Proteins Protein-Protein Interactions dataset.|
|Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles||cell lines with high or low copy number of RNY1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.|