|Name||Nanog homeobox pseudogene 8|
|Description||This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]|
|Synonyms||NANOG, PN8, NANOGP1|
|NCBI Gene ID||388112|
|Expression in Tissues and Cell Lines||
NANOGP8 has 254 functional associations with biological entities spanning 3 categories (functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue) extracted from 5 datasets.
Click the + buttons to view associations for NANOGP8 from the datasets below.
If available, associations are ranked by standardized value
|GeneRIF Biological Term Annotations||biological terms co-occuring with NANOGP8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|GTEx Tissue Gene Expression Profiles||tissues with high or low expression of NANOGP8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.|
|GTEx Tissue Sample Gene Expression Profiles||tissue samples with high or low expression of NANOGP8 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.|
|Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles||cell lines with high or low expression of NANOGP8 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.|
|HuGE Navigator Gene-Phenotype Associations||phenotypes associated with NANOGP8 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.|