NANOGP8 Gene

HGNC Family Homeoboxes
Name Nanog homeobox pseudogene 8
Description This locus is a processed pseudogene of the transcription factor NANOG. NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells. This pseudogene contains an intact open reading frame that could potentially encode a protein similar to NANOG. Although there is no evidence of transcription from this pseudogene, RT-PCR studies suggest that NANOGP8 may be expressed in some cancer cell lines. In vitro studies using a recombinant NANOGP8 protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to NANOG. [provided by RefSeq, Sep 2009]
Synonyms NANOG, PN8, NANOGP1
Proteins NANP8_HUMAN
NCBI Gene ID 388112
API
Download Associations
Predicted Functions View NANOGP8's ARCHS4 Predicted Functions.
Co-expressed Genes View NANOGP8's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View NANOGP8's ARCHS4 Predicted Functions.

Functional Associations

NANOGP8 has 254 functional associations with biological entities spanning 3 categories (functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue) extracted from 5 datasets.

Click the + buttons to view associations for NANOGP8 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneRIF Biological Term Annotations biological terms co-occuring with NANOGP8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of NANOGP8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of NANOGP8 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of NANOGP8 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with NANOGP8 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.