KIR2DL5B Gene

HGNC Family Immunoglobulin superfamily domain containing, Killer cell immunoglobulin-like receptors (KIR)
Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Synonyms KIR2DLX, KIR2DL5.2
Proteins KI2LB_HUMAN
NCBI Gene ID 553128
API
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Predicted Functions View KIR2DL5B's ARCHS4 Predicted Functions.
Co-expressed Genes View KIR2DL5B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View KIR2DL5B's ARCHS4 Predicted Functions.

Functional Associations

KIR2DL5B has 145 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for KIR2DL5B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CHEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIR2DL5B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
CHEA Transcription Factor Targets transcription factors binding the promoter of KIR2DL5B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with KIR2DL5B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with KIR2DL5B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of KIR2DL5B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of KIR2DL5B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with KIR2DL5B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of KIR2DL5B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of KIR2DL5B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.