H2AFB3 Gene

HGNC Family Histones
Name H2A histone family, member B3
Description Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. [provided by RefSeq, Jul 2008]
Synonyms H2AFB, H2ABBD
NCBI Gene ID 83740
API
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Predicted Functions View H2AFB3's ARCHS4 Predicted Functions.
Co-expressed Genes View H2AFB3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View H2AFB3's ARCHS4 Predicted Functions.

Functional Associations

H2AFB3 has 310 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for H2AFB3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing H2AFB3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with H2AFB3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of H2AFB3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of H2AFB3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of H2AFB3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with H2AFB3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing H2AFB3 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of H2AFB3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of H2AFB3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of H2AFB3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of H2AFB3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of H2AFB3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of H2AFB3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for H2AFB3 from the Pathway Commons Protein-Protein Interactions dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of H2AFB3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of H2AFB3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TRANSFAC Predicted Transcription Factor Targets transcription factors regulating expression of H2AFB3 gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.