|HGNC Family||Apolipoprotein B mRNA editing enzyme, catalytic polypeptides (APOBEC)|
|Name||APOBEC3A and APOBEC3B deletion hybrid|
|Description||This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]|
|NCBI Gene ID||100913187|
|Expression in Tissues and Cell Lines||
APOBEC3A_B has 64 functional associations with biological entities spanning 4 categories (chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.
Click the + buttons to view associations for APOBEC3A_B from the datasets below.
If available, associations are ranked by standardized value
|CCLE Cell Line Gene CNV Profiles||cell lines with high or low copy number of APOBEC3A_B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.|
|COSMIC Cell Line Gene CNV Profiles||cell lines with high or low copy number of APOBEC3A_B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.|
|GEO Signatures of Differentially Expressed Genes for Small Molecules||small molecule perturbations changing expression of APOBEC3A_B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.|
|GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations||transcription factor perturbations changing expression of APOBEC3A_B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.|
|InterPro Predicted Protein Domain Annotations||protein domains predicted for APOBEC3A_B protein from the InterPro Predicted Protein Domain Annotations dataset.|
|Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles||cell types and tissues with high or low DNA methylation of APOBEC3A_B gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.|