PID Pathways Dataset

Description sets of proteins participating in pathways
Measurement association by literature curation
Association protein-pathway associations from curated pathways
Category structural or functional annotations
Resource Pathway Interaction Database
Last Updated
  1. 2510 genes
  2. 223 pathways
  3. 8027 gene-pathway associations

Data Access



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pathway Gene Sets

223 sets of proteins participating in pathways from the PID Pathways dataset.

Gene Set Description
a4b7 Integrin signaling
a6b1 and a6b4 Integrin signaling
ALK1 pathway
ALK1 signaling events
ALK2 signaling events
Alpha-synuclein signaling
Alpha4 beta1 integrin signaling events
Alpha6 beta4 integrin-ligand interactions
Alpha9 beta1 integrin signaling events
AlphaE beta7 integrin cell surface interactions
Alternative NF-kappaB pathway
amb2 Integrin signaling
Angiopoietin receptor Tie2-mediated signaling
AP-1 transcription factor network
Arf1 pathway
Arf6 downstream pathway
Arf6 signaling events
Arf6 trafficking events
ATF-2 transcription factor network
ATM pathway The p53-dependent pathway of G1 arrest in response to damaged DNA.
ATR signaling pathway The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair.
Atypical NF-kappaB pathway
Aurora A signaling
Aurora B signaling
Aurora C signaling
BARD1 signaling events
BCR signaling pathway
Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions
Beta3 integrin cell surface interactions
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
BMP receptor signaling
C-MYB transcription factor network
C-MYC pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcium signaling in the CD4+ TCR pathway
Canonical NF-kappaB pathway
Canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Caspase Cascade in Apoptosis
CD40/CD40L signaling
CDC42 signaling events
Cellular roles of Anthrax toxin
Ceramide signaling pathway Ceramide signaling can act as a lipid second messenger or as a mediator of various cellular signaling pathways by promoting receptor clustering. The pathway plays important roles in apoptosis.
Circadian rhythm pathway
Class I PI3K signaling events
Class I PI3K signaling events mediated by Akt
Class IB PI3K non-lipid kinase events
Coregulation of Androgen receptor activity
CXCR3-mediated signaling events
CXCR4-mediated signaling events
Degradation of beta catenin
Direct p53 effectors
DNA-PK pathway in nonhomologous end joining
Downstream signaling in naïve CD8+ T cells
E-cadherin signaling events
E-cadherin signaling in keratinocytes
E-cadherin signaling in the nascent adherens junction
E2F transcription factor network
Effects of Botulinum toxin
EGF receptor (ErbB1) signaling pathway
EGFR-dependent Endothelin signaling events
Endogenous TLR signaling
EPHA forward signaling
EPHA2 forward signaling
EPHB forward signaling
Ephrin A reverse signaling
Ephrin B reverse signaling
EphrinA-EPHA pathway
EphrinB-EPHB pathway
EPO signaling pathway Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
ErbB receptor signaling network
ErbB1 downstream signaling
ErbB2/ErbB3 signaling events
ErbB4 signaling events
Fanconi anemia pathway Interstrand cross links (ICL) of DNA can be induced by both endogenous and exogenous ligands. ICL if not repaired will lead to cell death. ICL repair pathway, also known as Fanconi anemia pathway is the cellular response to this type of DNA damage.
FAS (CD95) signaling pathway
Fc-epsilon receptor I signaling in mast cells
FGF signaling pathway The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and relies on Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
FOXA transcription factor networks
FOXA1 transcription factor network
FOXA2 and FOXA3 transcription factor networks
FOXM1 transcription factor network
FoxO family signaling
Glucocorticoid receptor regulatory network
Glypican 1 network
Glypican 2 network
Glypican 3 network
Glypican pathway
GMCSF-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
HIF-1-alpha transcription factor network
HIF-2-alpha transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
IFN-gamma pathway
IGF1 pathway
IL1-mediated signaling events
IL12 signaling mediated by STAT4
IL12-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
IL2-mediated signaling events
IL23-mediated signaling events
IL27-mediated signaling events
IL3-mediated signaling events
IL4-mediated signaling events
IL5-mediated signaling events
IL6-mediated signaling events
IL8- and CXCR1-mediated signaling events
IL8- and CXCR2-mediated signaling events
IL8-mediated signaling events
Insulin Pathway
Insulin-mediated glucose transport
Integrin family cell surface interactions
Integrin-linked kinase signaling
Integrins in angiogenesis
Internalization of ErbB1
JNK signaling in the CD4+ TCR pathway
Lissencephaly gene (LIS1) in neuronal migration and development
LKB1 signaling events
LPA receptor mediated events
LPA4-mediated signaling events
mTOR signaling pathway mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients.
N-cadherin signaling events
Nectin adhesion pathway
Nephrin/Neph1 signaling in the kidney podocyte
Netrin-mediated signaling events
Neurotrophic factor-mediated Trk receptor signaling
Noncanonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
Nongenotropic Androgen signaling
Notch signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Notch-mediated HES/HEY network
Osteopontin-mediated events
p38 MAPK signaling pathway A SAPK MAPK pathway that plays an important role in inflammation and may be involved in several forms of cancer.
p38 signaling mediated by MAPKAP kinases
p53 pathway
p73 transcription factor network
p75(NTR)-mediated signaling
PAR1-mediated thrombin signaling events
PAR4-mediated thrombin signaling events
PDGF receptor signaling network
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Plasma membrane estrogen receptor signaling
Plexin-D1 Signaling
PLK1 signaling events
PLK2 and PLK4 events
PLK3 signaling events
Polo-like kinase signaling events in the cell cycle
Posttranslational regulation of adherens junction stability and dissassembly
Presenilin action in Notch and Wnt signaling
Proteoglycan syndecan-mediated signaling events
RAC1 signaling pathway
Rapid glucocorticoid signaling
Ras signaling in the CD4+ TCR pathway
Reelin signaling pathway Reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in the schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
Regulation of Androgen receptor activity Any process that modulates the frequency, rate or extent of androgen receptor activity.
Regulation of CDC42 activity
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Regulation of nuclear beta catenin signaling and target gene transcription
Regulation of nuclear SMAD2/3 signaling
Regulation of p38-alpha and p38-beta
Regulation of RAC1 activity
Regulation of Ras family activation
Regulation of retinoblastoma protein
Regulation of RhoA activity
Regulation of Telomerase
Retinoic acid receptors-mediated signaling
RhoA signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
RXR and RAR heterodimerization with other nuclear receptor
S1P1 pathway
S1P2 pathway
S1P3 pathway
S1P4 pathway
S1P5 pathway
SHP2 signaling
Signaling by Aurora kinases
Signaling events mediated by focal adhesion kinase
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class III
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PRL
Signaling events mediated by PTP1B
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
Signaling events mediated by the Hedgehog family
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
Signaling mediated by p38-alpha and p38-beta
Signaling mediated by p38-gamma and p38-delta
Sphingosine 1-phosphate (S1P) pathway
Stabilization and expansion of the E-cadherin adherens junction
Sumoylation by RanBP2 regulates transcriptional repression
Syndecan-1-mediated signaling events
Syndecan-2-mediated signaling events
Syndecan-3-mediated signaling events
Syndecan-4-mediated signaling events
TCR signaling in naïve CD4+ T cells
TCR signaling in naïve CD8+ T cells
TGF-beta receptor signaling
Thrombin/protease-activated receptor (PAR) pathway
Thromboxane A2 receptor signaling
TNF receptor signaling pathway
TRAIL signaling pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Trk receptor signaling mediated by the MAPK pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Validated nuclear estrogen receptor alpha network
Validated nuclear estrogen receptor beta network
Validated targets of C-MYC transcriptional activation
Validated targets of C-MYC transcriptional repression
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
VEGF and VEGFR signaling network
VEGFR1 specific signals
VEGFR3 signaling in lymphatic endothelium
Visual signal transduction: Cones
Visual signal transduction: Rods
Wnt signaling network