LINCS KinomeScan Kinase Inhibitor Targets Dataset

Description kinase inhibitor targets from percent inhibition of kinases by small molecules measured using purified kinases
Measurement chemical bioactivity
Association kinase-small molecule associations by percent inhibition of kinase by small molecule
Category physical interactions
Resource LINCS KinomeScan
Last Updated
Stats
  1. 277 genes
  2. 71 small molecules
  3. 2057 gene-small molecule associations

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small molecule Gene Sets

71 sets of kinases inhibited by small molecules from the KinomeScan Kinase Inhibitor Targets dataset.

Gene Set Description
(R)- Roscovitine
5z-7-oxozeaenol A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB.
AG1478
ALW-II-38-3
AS601245
AZ-628
AZD 5438
AZD-6482
AZD4547 A member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR).
Barasertib
BEZ235
BMS345541
Bosutinib
BS-181
BX-912
CG-930
CGP60474
CGP74514A
CP466722
CP724714
Crizotinib
Dabrafenib An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Dinaciclib
GDC-0941
GSK1059615 A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor
GSK2126458
GSK429286A
GSK461364
GW-5074
GW843682
HG-14-8-02
HG-6-64-01
JNK-9L
JWE-035
KIN001-220
KU63794
Lapatinib
MLN8054
Momelotinib
Neratinib A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position.
NU7441
OTSSP167
PD0332991
PHA-767491
PHA-793887
PLX-4720
PLX4032
QL-X-138
QL-XI-92
RO-3306
SB590885
Sigma A6730
Sorafenib
TAK-715
THZ-2-98-01
Torin1 A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1.
Torin2
WYE-125132
WZ-7043
WZ3105
XMD-12
XMD11-50
XMD11-85h
XMD13-2
XMD14-99
XMD15-27
XMD16-144
XMD8-85
XMD8-92 A dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a [2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino substituent. It is an inhibitor of the BMK1 kinase pathway.
ZG-10
ZM-447439