GO Molecular Function Annotations Dataset

Description curated annotations of genes with molecular functions
Measurement association by literature curation
Association gene-molecular function associations from curated gene annotations
Category structural or functional annotations
Resource Gene Ontology
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  1. 15777 genes
  2. 4162 molecular functions
  3. 223181 gene-molecular function associations

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molecular function Gene Sets

4162 sets of genes performing molecular functions from the curated GO Molecular Function Annotations dataset.

Gene Set Description
n-acetyl-beta-glucosaminyl-glycoprotein 4-beta-n-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
translation activator activity Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.
ubiquitinyl hydrolase activity Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
syntaxin-3 binding Interacting selectively and non-covalently with the SNAP receptor syntaxin-3.
taurine:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in).
udp-sugar diphosphatase activity Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.
polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
neurotrophin receptor binding Interacting selectively and non-covalently with a neurotrophin receptor.
peroxisome membrane class-1 targeting sequence binding Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.
sulfur amino acid transmembrane transporter activity Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.
glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.
transcription coactivator activity Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
succinate-semialdehyde dehydrogenase binding Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase.
glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
oxidoreductase activity, acting on the ch-nh group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound.
pyrimidine-specific mismatch base pair dna n-glycosylase activity Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
glycoprotein-fucosylgalactoside alpha-n-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP.
activating transcription factor binding Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
ethanol binding Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
kynureninase activity Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
vascular endothelial growth factor receptor 2 binding Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.
dynein binding Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules.
polyamine binding Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups.
vasopressin receptor binding Interacting selectively and non-covalently with a vasopressin receptor.
serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
atp-dependent polynucleotide kinase activity Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.
phosphate ion transmembrane transporter activity Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other.
selenide, water dikinase activity Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.
ciliary neurotrophic factor receptor binding Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor.
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.
carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
large conductance calcium-activated potassium channel activity Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
tryptophan-trna ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).
leukemia inhibitory factor receptor binding Interacting selectively and non-covalently with the leukemia inhibitory factor receptor.
titin binding Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
myosin ii heavy chain binding Interacting selectively and non-covalently with a heavy chain of a myosin II complex.
ligase regulator activity Modulates the activity of a ligase.
aspartic-type endopeptidase inhibitor activity Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
mhc class ib protein binding, via antigen binding groove Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove.
interleukin-8 receptor activity Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
ige receptor activity Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
thymidine kinase activity Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.
cholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
dinucleotide repeat insertion binding Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats.
phosphotransferase activity, paired acceptors Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors.
cyclic-gmp-amp binding Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide.
l-glutamine:pyruvate aminotransferase activity Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine.
formate uptake transmembrane transporter activity Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane.
cytidine deaminase activity Catalysis of the reaction: cytidine + H2O = uridine + NH3.
hydroxymethylglutaryl-coa lyase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.
interleukin-12 receptor binding Interacting selectively and non-covalently with the interleukin-12 receptor.
jun kinase activity Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors.
gastrin receptor activity Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity.
heterotrimeric g-protein binding Interacting selectively and non-covalently with a heterotrimeric G-protein.
alpha1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
melanin-concentrating hormone activity The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.
carbonyl reductase (nadph) activity Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
ditp diphosphatase activity Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.
n1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine.
lbd domain binding Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.
ufm1 transferase activity Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages.
dopachrome isomerase activity Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol.
myosin light chain binding Interacting selectively and non-covalently with a light chain of a myosin complex.
oxidoreductase activity, acting on superoxide radicals as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor.
gtp binding Interacting selectively and non-covalently with GTP, guanosine triphosphate.
protein binding involved in cell-matrix adhesion Any protein binding that is involved in cell-matrix adhesion.
deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.
fatty acid ligase activity Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
3'-nucleotidase activity Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.
acetylcholine receptor regulator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor.
5(s)-hydroxyperoxy-6e,8z,11z,14z-icosatetraenoic acid binding Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds.
phosphatidylglycerophosphatase activity Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
kainate selective glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist.
intracellular calcium activated chloride channel activity Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
rna polymerase i transcription factor recruiting transcription factor activity The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I.
methylenetetrahydrofolate dehydrogenase [nad(p)+] activity
methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
15-oxoprostaglandin 13-oxidase activity Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+.
hedgehog receptor activity Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.
guanosine-diphosphatase activity Catalysis of the reaction: GDP + H2O = GMP + phosphate.
atp-activated inward rectifier potassium channel activity Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
edg-2 lysophosphatidic acid receptor binding Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.
arginase activity Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.
purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
chloride channel activity Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
glycerophosphoinositol inositolphosphodiesterase activity Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol.
iodide transmembrane transporter activity Catalysis of the transfer of iodide ions from one side of a membrane to the other.
n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
signal transducer activity Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
kynurenine 3-monooxygenase activity Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).
glycine transmembrane transporter activity Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid.
4-hydroxybenzoate nonaprenyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate.
l-gulonate 3-dehydrogenase activity Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.
lysophosphatidic acid phosphatase activity Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol.
peroxidase activity Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
cofactor transporter activity Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein.
lysine-acetylated histone binding Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
cysteamine dioxygenase activity Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine.
type i activin receptor binding Interacting selectively and non-covalently with a type I activin receptor.
microfilament motor activity Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
tryptophan 5-monooxygenase activity Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.
fatty acid binding Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
activin binding Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
ornithine decarboxylase inhibitor activity The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
v1a vasopressin receptor binding Interacting selectively and non-covalently with a V1A vasopressin receptor.
phospholipase activator activity Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid.
rna polymerase iii regulatory region dna binding Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
nuclear hormone receptor binding Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
dna-7-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.
ubiquitin-specific protease binding Interacting selectively and non-covalently with a ubiquitin-specific protease.
aminoacetone:oxygen oxidoreductase(deaminating) activity Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+.
udp-xylose transmembrane transporter activity Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate.
gdp-dissociation inhibitor binding Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein.
cyclase regulator activity Modulates the activity of an enzyme that catalyzes a ring closure reaction.
mdm2/mdm4 family protein binding Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53.
4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.
stem cell factor receptor activity Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
thymine binding Interacting selectively and non-covalently with thymine.
o-phospho-l-serine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
hepatocyte growth factor binding Interacting selectively and non-covalently with a hepatocyte growth factor.
vascular endothelial growth factor receptor 1 binding Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1.
alpha-1,3-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose.
adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
progesterone receptor binding Interacting selectively and non-covalently with a progesterone receptor.
dolichol kinase activity Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.
fatty acid alpha-hydroxylase activity Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain.
retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
amino acid kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.
adenine binding Interacting selectively and non-covalently with adenine, a purine base.
neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity.
t cell receptor binding Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.
tapasin binding Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules.
thyrotropin-releasing hormone receptor activity Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
propanoyl-coa c-acyltransferase activity Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.
olfactory receptor activity Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
l-serine ammonia-lyase activity Catalysis of the reaction: L-serine = pyruvate + NH3.
protein methylesterase activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol.
s-methylmethionine-homocysteine s-methyltransferase activity Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+.
intramolecular oxidoreductase activity, interconverting aldoses and ketoses Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears.
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-coa 24-hydroxylase activity Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor.
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
thiomorpholine-carboxylate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate.
monosaccharide transmembrane transporter activity Catalysis of the transfer of a monosaccharide from one side of a membrane to the other.
l-proline transmembrane transporter activity Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
5'-3' exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule.
interleukin-18 receptor activity Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
methylthiotransferase activity Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor.
androgen receptor binding Interacting selectively and non-covalently with an androgen receptor.
protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine.
acetyl-coa transporter activity Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
thiamine phosphate phosphatase activity Catalysis of the hydrolysis of thiamine phosphate.
hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
tyrosine binding Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid.
protein transmembrane transporter activity Catalysis of the transfer of a protein from one side of a membrane to the other.
fat10 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond.
binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
proline-rich region binding Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
methylenetetrahydrofolate dehydrogenase (nad+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.
phosphate ion binding Interacting selectively and non-covalently with phosphate.
transferase activity, transferring pentosyl groups Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).
chondroitin-glucuronate 5-epimerase activity Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate.
neurohypophyseal hormone activity The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin.
nadph binding Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
cysteine-type endopeptidase activator activity involved in apoptotic process Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
endocytic adaptor activity The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex as a key step in receptor mediated endocytosis.
wnt-activated receptor activity Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
telomeric dna binding Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
c-c motif chemokine 21 receptor activity Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
threonine aldolase activity Catalysis of the reaction: L-threonine = glycine + acetaldehyde.
6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
nerve growth factor binding Interacting selectively and non-covalently with nerve growth factor (NGF).
putrescine transmembrane transporter activity Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
coenzyme transporter activity Enables the directed movement of a coenzyme into, out of or within a cell, or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
tfiib-class binding transcription factor activity Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
dna nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
nucleoside phosphotransferase activity Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate.
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.
receptor antagonist activity Interacts with receptors to reduce the action of another ligand, the agonist.
phosphotyrosine binding Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
n1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine.
aldehyde oxidase activity Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
bh4 domain binding Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.
dodecenoyl-coa delta-isomerase activity Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA.
atp-binding and phosphorylation-dependent chloride channel activity Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
phosphoprotein binding Interacting selectively and non-covalently with a phosphorylated protein.
steroid receptor rna activator rna binding Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.
protein binding, bridging The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
xanthine dehydrogenase activity Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
receptor binding Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
nucleoside phosphate kinase activity Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate.
substrate-specific transporter activity Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
nitrate transmembrane transporter activity Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2.
hepoxilin a3 synthase activity Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
proteasome binding Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
(r)-limonene 6-monooxygenase activity Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+.
glucocorticoid receptor activity Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.
3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
sodium:chloride symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in).
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.
phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.
small molecule binding Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
beta-catenin binding Interacting selectively and non-covalently with the beta subunit of the catenin complex.
mannose transmembrane transporter activity Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
actin monomer binding Interacting selectively and non-covalently with monomeric actin, also known as G-actin.
hexose transmembrane transporter activity Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.
cholinesterase activity Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
sphingomyelin phosphodiesterase activator activity Increases the activity of the enzyme sphingomyelin phosphodiesterase.
dynactin binding Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity.
glycolipid 6-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.
pdz domain binding Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
nitrilase activity Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
glycosphingolipid binding Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
nicotinate phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate.
peptide disulfide oxidoreductase activity Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds.
protein-lipid complex binding Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules.
neurexin family protein binding Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
proton-transporting atpase activity, rotational mechanism Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.
nadp+ binding
histone demethylase activity Catalysis of the removal of a methyl group from a histone.
arsenate reductase activity Catalysis of the interconversion of arsenate and arsenite.
acetylcholine receptor activity Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
ethanolaminephosphotransferase activity Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.
high-affinity l-ornithine transmembrane transporter activity Catalysis of the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
ribosomal large subunit binding Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
ligase inhibitor activity Stops, prevents or reduces the activity of a ligase.
n-acetyllactosamine synthase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
protein phosphatase type 4 regulator activity Modulation of the activity of the enzyme protein phosphatase type 4.
serine o-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.
fibroblast growth factor binding Interacting selectively and non-covalently with a fibroblast growth factor.
intramolecular lyase activity The catalysis of certain rearrangements of a molecule to break or form a ring.
rna polymerase i regulatory region dna binding Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
lipopolysaccharide receptor activity Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
methyl-cpg binding Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.
phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
nutrient reservoir activity Functions in the storage of nutritious substrates.
endoribonuclease activity, cleaving mirna-paired mrna
nitric-oxide synthase inhibitor activity Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase.
phosphohistidine phosphatase activity Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate.
neurotransmitter:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in).
collagen receptor activity Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
rna polymerase ii basal transcription factor binding transcription factor activity Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
serine racemase activity Catalysis of the synthesis of free D-serine from L-serine.
type i interferon receptor activity Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
nucleotidase activity Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.
g-protein coupled chemoattractant receptor activity Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
mannokinase activity Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.
u5 snrna binding Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA).
hepatocyte growth factor-activated receptor activity Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
acyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid.
beta-galactoside alpha-2,3-sialyltransferase activity Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor.
5'-3' dna helicase activity Catalysis of the unwinding of the DNA helix in the direction 5' to 3'.
translation factor activity, nucleic acid binding Functions during translation by interacting selectively and non-covalently with nucleic acids during polypeptide synthesis at the ribosome.
succinate-coa ligase (gdp-forming) activity Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.
thrombin receptor activity Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
pyridoxamine-phosphate oxidase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide.
intracellular camp activated cation channel activity Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.
protein-arginine deiminase activity Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3.
g-protein coupled purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
sphingolipid delta-4 desaturase activity Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid.
glucoside transmembrane transporter activity Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue.
retinoic acid 4-hydroxylase activity Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
interleukin-1 type ii receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.
beta-amyloid binding Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor.
secondary active monocarboxylate transmembrane transporter activity Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.
alpha-catenin binding Interacting selectively and non-covalently with the alpha subunit of the catenin complex.
cyclase inhibitor activity Decreases the activity of an enzyme that catalyzes a ring closure reaction.
l-dopa decarboxylase activator activity Interacts with and increases L-dopa decarboxylase activity.
riboflavin reductase (nadph) activity Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.
inorganic anion exchanger activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
thyroid-stimulating hormone receptor activity Combining with thyroid-stimulating hormone to initiate a change in cell activity.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
protein heterodimerization activity Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
l-phenylalanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate.
single-stranded dna 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.
polyprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+.
retinoid binding Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
raffinose alpha-galactosidase activity Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose.
signaling pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.
camp-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP.
voltage-gated potassium channel activity involved in sa node cell action potential repolarization Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
temperature-gated ion channel activity Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).
beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
pantothenate kinase activity Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
aspartoacylase activity Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate.
branched-chain amino acid transmembrane transporter activity Catalysis of the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings.
lathosterol oxidase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2.
histone kinase activity (h3-s10 specific) Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.
wide pore channel activity Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
glutamate receptor activity Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+).
n-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
pyrimidine nucleotide-sugar transmembrane transporter activity Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane.
acylglycerol kinase activity Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.
g-protein coupled neurotensin receptor activity Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
fmn adenylyltransferase activity Catalysis of the reaction: ATP + FMN = diphosphate + FAD.
threonine synthase activity Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate.
cyclin-dependent protein kinase 5 activator activity Increases the activity of cyclin-dependent protein kinase 5.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
gbd domain binding Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.
phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
inositol hexakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.
phosphatidylinositol phosphate 5-phosphatase activity Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate.
l-cysteine desulfhydrase activity Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+.
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators.
low-affinity sodium:dicarboxylate symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.
d2 dopamine receptor binding Interacting selectively and non-covalently with a D2 dopamine receptor.
tfiib-class transcription factor binding Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
high-affinity lysine transmembrane transporter activity Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
sulfur compound transmembrane transporter activity Catalysis of the transfer of a sulfur compound from one side of the membrane to the other.
endodeoxyribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
dna translocase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule.
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
oxidoreductase activity, acting on iron-sulfur proteins as donors Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
double-stranded rna-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.
l-asparagine transmembrane transporter activity Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid.
mannosyl-oligosaccharide glucosidase activity Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
protein phosphatase 2a binding Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
choloyl-coa hydrolase activity Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.
glycosaminoglycan binding Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
sterol transporter activity Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
hydrogen:amino acid symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in).
o-acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule.
voltage-gated sodium channel activity involved in cardiac muscle cell action potential Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
sodium:amino acid symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
fc-gamma receptor i complex binding Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.
succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol.
core promoter binding Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
aldehyde dehydrogenase (nad) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
gap junction hemi-channel activity A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.
eukaryotic initiation factor 4g binding Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
prostaglandin-endoperoxide synthase activity Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
glycosylceramidase activity Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine.
thioesterase binding Interacting selectively and non-covalently with any thioesterase enzyme.
mutlbeta complex binding Interacting selectively and non-covalently with the mismatch repair complex MutLbeta.
opsonin binding Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.
gap junction channel activity A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
enterobactin transporter activity Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells.
dipeptide transporter activity Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells.
phospholipid binding Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
d1 dopamine receptor binding Interacting selectively and non-covalently with a D1 dopamine receptor.
ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.
transcription factor binding Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
carbon-nitrogen ligase activity, with glutamine as amido-n-donor Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
phospholipase inhibitor activity Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.
rna stem-loop binding Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
interleukin-23 receptor activity Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
gpi-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity.
glutamine-fructose-6-phosphate transaminase (isomerizing) activity Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.
proton-transporting atp synthase activity, rotational mechanism Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism.
snap receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
fatty-acyl-coa synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
core promoter proximal region dna binding Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.
udp-glucose 6-dehydrogenase activity Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.
guanyl nucleotide binding Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.
l-tyrosine transmembrane transporter activity Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.
n-acetylgalactosamine 4-sulfate 6-o-sulfotransferase activity Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.
histone demethylase activity (h3-r2 specific) Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein.
protein phosphatase type 1 activator activity Increases the activity of the enzyme protein phosphatase type 1.
atp:adp antiporter activity Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out).
rs domain binding Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.
sarcosine oxidase activity Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2).
14-3-3 protein binding Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
aryl hydrocarbon receptor binding Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
potassium:chloride symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).
caax-protein geranylgeranyltransferase activity Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
inhibitory extracellular ligand-gated ion channel activity Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
v1b vasopressin receptor binding Interacting selectively and non-covalently with a V1B vasopressin receptor.
l-alanine transmembrane transporter activity Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid.
n-acylmannosamine kinase activity Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.
dopamine:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in).
protein-dna loading atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protein complex onto a DNA molecule.
cupric ion binding Interacting selectively and non-covalently with cupric ion, copper(2+).
acylphosphatase activity Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
amino acid transmembrane transporter activity Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
carboxylic acid binding Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
delta14-sterol reductase activity Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.
nadph-adrenodoxin reductase activity Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
rdna binding Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
bisphosphoglycerate 3-phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.
phosphatidylinositol phosphate 4-phosphatase activity Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.
o-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
tumor necrosis factor-activated receptor activity Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.
interferon binding Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.
prostaglandin transmembrane transporter activity Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
methylarsonite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
glycerol-3-phosphate dehydrogenase activity Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
3-demethylubiquinone-n 3-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
transcription termination site sequence-specific dna binding Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
rrna primary transcript binding Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript.
mitogen-activated protein kinase kinase kinase binding Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
tachykinin receptor activity Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.
cysteine transmembrane transporter activity Catalysis of the transfer of cysteine from one side of the membrane to the other.
proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
linoleate 13s-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
asparagine-trna ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
sedoheptulokinase activity Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate.
dna/rna helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
glutamate-trna ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
syntaxin-1 binding Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
n-acylneuraminate cytidylyltransferase activity Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
sodium:dicarboxylate symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in).
taurochenodeoxycholate 6alpha-hydroxylase activity Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O.
tripeptidase activity Catalysis of the hydrolysis of a tripeptide.
deoxynucleotide transmembrane transporter activity Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.
placental growth factor-activated receptor activity Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
spermidine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.
trna guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.
[acetyl-coa carboxylase] kinase activity Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
tubulin-tyrosine ligase activity Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
glycogen synthase activity, transferring glucose-1-phosphate Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.
2-acylglycerol o-acyltransferase activity Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
e-box binding Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
mrna (nucleoside-2'-o-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
3-galactosyl-n-acetylglucosaminide 4-alpha-l-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.
sphingosine n-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.
pituitary adenylate cyclase activating polypeptide activity The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.
fructose transmembrane transporter activity Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
type 1 hypocretin receptor binding Interacting selectively and non-covalently with a type 1 hypocretin receptor.
oxidoreductase activity, acting on ch or ch2 groups, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule.
phosphatidylglycerol binding Interacting selectively and non-covalently with phosphatidylglycerol.
prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).
alanine transmembrane transporter activity Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.
ceramide kinase activity Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.
tryptophan 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
cgmp-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP.
myosin binding Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
ligase activity, forming carbon-carbon bonds Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
nad(p)+ transhydrogenase (ab-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
macromolecule transmembrane transporter activity Catalysis of the transfer of a macromolecule from one side of the membrane to the other.
interleukin-2 receptor binding Interacting selectively and non-covalently with the interleukin-2 receptor.
peptide antigen binding Interacting selectively and non-covalently with an antigen peptide.
corticotropin-releasing hormone receptor binding Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.
triphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group.
smoothened binding Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.
angiotensin receptor binding Interacting selectively and non-covalently with an angiotensin receptor.
calcium-dependent phospholipase a2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+.
type 2 angiotensin receptor binding Interacting selectively and non-covalently with a type 2 angiotensin receptor.
bradykinin receptor activity Combining with bradykinin to initiate a change in cell activity.
fatty acid derivative binding Interacting selectively and non-covalently with fatty acid derivative.
atp-dependent rna helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
voltage-gated sodium channel activity Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
alkylglycerophosphoethanolamine phosphodiesterase activity Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.
nucleic acid binding transcription factor activity Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
sphingomyelin phosphodiesterase d activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+).
agmatinase activity Catalysis of the reaction: agmatine + H(2)O = putrescine + urea.
phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor).
retinoic acid-responsive element binding Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind.
ubiquitin protein ligase binding Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
antiporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
calmodulin-lysine n-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine.
high-affinity sodium:dicarboxylate symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
rab guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
inositol monophosphate 1-phosphatase activity Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.
tripeptidyl-peptidase activity Catalysis of the release of an N-terminal tripeptide from a polypeptide.
alanine-glyoxylate transaminase activity Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
deoxycytidine kinase activity Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
lipoprotein particle receptor activity Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
ribosome binding Interacting selectively and non-covalently with any part of a ribosome.
aliphatic-amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
aminoacyl-trna editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
calcitriol receptor activity Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
type 2 hypocretin receptor binding Interacting selectively and non-covalently with a type 2 hypocretin receptor.
glutamate-ammonia ligase activity Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate.
2'-phosphotransferase activity Catalysis of the transfer of a phosphate group from one compound to the 2' position of another.
purine ribonucleoside binding Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose.
4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor.
high voltage-gated calcium channel activity Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
l-glutamate transmembrane transporter activity Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.
heparan sulfate proteoglycan binding Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
rna polymerase iii activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
epidermal growth factor binding Interacting selectively and non-covalently with epidermal growth factor.
glycoprotein-n-acetylgalactosamine 3-beta-galactosyltransferase activity Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan.
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
semaphorin receptor binding Interacting selectively and non-covalently with semaphorin receptors.
ferredoxin-nadp+ reductase activity
alpha-2b adrenergic receptor binding Interacting selectively and non-covalently with an alpha-2B adrenergic receptor.
estrogen receptor binding Interacting selectively and non-covalently with an estrogen receptor.
exo-alpha-(2->8)-sialidase activity Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates.
nacht domain binding Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
aminomethyltransferase activity Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.
deoxyribonucleoside 5'-monophosphate n-glycosidase activity Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.
gtpase activating protein binding Interacting selectively and non-covalently with a GTPase activating protein.
l-lysine transmembrane transporter activity Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid.
long-chain-enoyl-coa hydratase activity Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms.
trail binding Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.
guanine deaminase activity Catalysis of the reaction: guanine + H2O = xanthine + NH3.
somatostatin receptor binding Interacting selectively and non-covalently with a somatostatin receptor.
sepiapterin reductase activity Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+.
euchromatin binding Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin.
fructose-bisphosphate aldolase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.
beta-n-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides.
identical protein binding Interacting selectively and non-covalently with an identical protein or proteins.
sequence-specific dna binding transcription factor activity Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
channel activity Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
xanthine oxidase activity Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide.
l-pipecolate oxidase activity Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.
methylmalonyl-coa epimerase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.
single thymine insertion binding Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine.
chromatin insulator sequence binding Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription.
bile acid-exporting atpase activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate.
trna (guanine-n2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine.
protein transporter activity Enables the directed movement of proteins into, out of or within a cell, or between cells.
endogenous lipid antigen binding Interacting selectively and non-covalently with an endogenous cellular lipid antigen.
mu-type opioid receptor binding Interacting selectively and non-covalently with a mu-type opioid receptor.
tyrosine 3-monooxygenase activator activity Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity.
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
dopamine beta-monooxygenase activity Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.
rna polymerase iii core binding Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.
nociceptin receptor activity Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.
collagen binding involved in cell-matrix adhesion Any collagen binding that occurs as part of cell-matrix adhesion.
carbon-sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S.
inositol tetrakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate.
methylcrotonoyl-coa carboxylase activity Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.
acyl-coa dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
actin filament binding Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
platelet activating factor receptor activity Combining with platelet activating factor to initiate a change in cell activity.
pyroglutamyl-peptidase activity Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein.
ribonuclease p activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.
aminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
lipoprotein transporter activity Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells.
glycolipid binding Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate.
histone kinase activity (h3-y41 specific) The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.
histone methyltransferase activity (h3-k79 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein.
platelet-derived growth factor alpha-receptor activity Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.
transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
extracellular matrix structural constituent conferring tensile strength A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.
mitogen-activated protein kinase binding Interacting selectively and non-covalently with a mitogen-activated protein kinase.
type 1 galanin receptor binding Interacting selectively and non-covalently with a type 1 galanin receptor.
3-keto sterol reductase activity Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
dna-dependent atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
dolichyl-phosphate beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.
gtp-dependent protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.
inositol-1,4,5-trisphosphate 3-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
ceramide 1-phosphate binding Interacting selectively and non-covalently with ceramide 1-phosphate.
ligand-activated sequence-specific dna binding rna polymerase ii transcription factor activity Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule.
l-glucuronate reductase activity Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH.
prostaglandin d receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.
antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
s-succinyltransferase activity Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule.
short-chain fatty acid uptake transporter activity Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
rna polymerase ii transcription cofactor activity Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.
phosphatidylcholine transporter activity Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
tubulin n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine.
neurotrophin trka receptor binding Interacting selectively and non-covalently with the neurotrophin TRKA receptor.
virus receptor activity Combining with a virus component and mediating entry of the virus into the cell.
ufm1 hydrolase activity Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates.
anion:cation symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
calcium channel regulator activity Modulates the activity of a calcium channel.
suramin binding Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.
udp-glucuronate decarboxylase activity Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose.
cob(i)yrinic acid a,c-diamide adenosyltransferase activity Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin.
dihydronicotinamide riboside quinone reductase activity Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.
histone demethylase activity (h4-r3 specific) Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein.
exo-alpha-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
lipase binding Interacting selectively and non-covalently with any lipase.
alkenylglycerophosphoethanolamine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde.
trna (uracil) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule.
diphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group.
androgen binding Interacting selectively and non-covalently with any androgen, male sex hormones.
dna (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
transferase activity, transferring alkylthio groups Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor).
igm binding Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype.
nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
succinate-coa ligase activity Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA.
dna-3-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.
l-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
glycerophosphocholine phosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline.
quaternary ammonium group transmembrane transporter activity Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
c4-dicarboxylate transmembrane transporter activity Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other.
nucleoside-diphosphatase activity Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.
rna ligase (atp) activity Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
transmembrane receptor protein serine/threonine kinase binding Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity.
glutathione disulfide oxidoreductase activity Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.
chromo shadow domain binding Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.
deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
succinate-semialdehyde dehydrogenase (nad+) activity Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+.
racemase and epimerase activity Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule.
muscle alpha-actinin binding Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
outward rectifier potassium channel activity Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
cholesterol binding Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
3'-5' rna helicase activity Catalysis of the unwinding of an RNA helix in the direction 3' to 5'.
nad(p)h dehydrogenase (quinone) activity
peptidoglycan binding Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
glutamate formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
guanidinoacetate n-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+).
box c/d snorna binding Interacting selectively and non-covalently with box C/D small nucleolar RNA.
oxidoreductase activity, acting on the ch-ch group of donors, with a flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.
lithocholic acid receptor activity Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity.
sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.
pituitary adenylate cyclase-activating polypeptide receptor binding Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor.
chondroitin 4-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.
phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate.
alpha-n-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.
small gtpase binding Interacting selectively and non-covalently with a small monomeric GTPase.
protein tag Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question.
corticotropin-releasing hormone activity The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary.
kappa-type opioid receptor binding Interacting selectively and non-covalently with a kappa-type opioid receptor.
estrogen receptor activity Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
oligopeptide binding Interacting selectively and non-covalently with an oligopeptide.
n6-(1,2-dicarboxyethyl)amp amp-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.
enkephalin receptor activity Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.
oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.
l-glutamine aminotransferase activity Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid.
glucose binding Interacting selectively and non-covalently with the D- or L-enantiomer of glucose.
acylglycerol o-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule.
cobalamin binding Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
demethylase activity Catalysis of the removal of a methyl group from a substrate.
nad(p)h oxidase activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide.
acetyltransferase activator activity Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.
type 1 angiotensin receptor binding Interacting selectively and non-covalently with a type 1 angiotensin receptor.
tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.
mhc class ii protein binding Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
zinc transporting atpase activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in).
s-acetyltransferase activity Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule.
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
icosanoid binding Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids.
endoribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
methylumbelliferyl-acetate deacetylase activity Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+).
glycylpeptide n-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
(n-acetylneuraminyl)-galactosylglucosylceramide n-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
spermine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.
leucine zipper domain binding Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.
glyoxylate oxidase activity Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate.
atg12 transferase activity Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages.
linoleic acid binding Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
o-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
atp citrate synthase activity Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA.
acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
substance p receptor activity Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity.
cation channel activity Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
acyl binding Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.
itp binding Interacting selectively and non-covalently with ITP.
phosphoglycolate phosphatase activity Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate.
steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
glucosamine-6-phosphate deaminase activity Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).
n-acetylgalactosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
glutamine-trna ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).
diphosphoinositol-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate.
rho guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.
ras gtpase binding Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
rna polymerase ii sequence-specific dna binding transcription factor binding Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
gamma-catenin binding Interacting selectively and non-covalently with the gamma subunit of the catenin complex.
nad+ diphosphatase activity Catalysis of the reaction: NAD+ + H2O = AMP + NMN.
mast cell secretagogue receptor activity
arachidonate 8(s)-lipoxygenase activity Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.
25-hydroxycholecalciferol-24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.
adp-ribose diphosphatase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
amine transmembrane transporter activity Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
telethonin binding Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.
potassium ion leak channel activity Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.
open rectifier potassium channel activity Catalysis of the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.
gdp-4-dehydro-d-rhamnose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.
oxytocin receptor binding Interacting selectively and non-covalently with an oxytocin receptor.
x11-like protein binding Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein.
rna polymerase i core element sequence-specific dna binding transcription factor recruiting transcription factor activity Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I.
rhodopsin kinase activity Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin.
secondary active transmembrane transporter activity Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport.
protein kinase c inhibitor activity Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.
leukotriene-b4 20-monooxygenase activity Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.
sh3 domain binding Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
l-dopa receptor activity Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine.
poz domain binding Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.
transcription factor binding transcription factor activity Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
prostaglandin-e2 9-reductase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
c3a anaphylatoxin receptor activity Combining with anaphylatoxin C3a to initiate a change in cell activity.
primary mirna binding Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.
ctp:3'-cytidine-trna cytidylyltransferase activity Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.
translation regulator activity Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
cdp-diacylglycerol-serine o-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.
calcium-dependent phospholipid binding Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
mutsbeta complex binding Interacting selectively and non-covalently with the mismatch repair complex MutSbeta.
s-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
calcium-independent phospholipase a2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.
bisphosphoglycerate mutase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.
double-stranded dna exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.
inositol pentakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate.
ion channel binding Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
dna helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
activating mhc class i receptor activity Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte.
rna polymerase i core element sequence-specific dna binding transcription factor activity Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I.
u6 snrna binding Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).
phenylpyruvate tautomerase activity Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.
adp binding Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
potassium ion binding Interacting selectively and non-covalently with potassium (K+) ions.
copper ion transmembrane transporter activity Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other.
interleukin-13 receptor binding Interacting selectively and non-covalently with the interleukin-13 receptor.
dopamine neurotransmitter receptor activity, coupled via gs Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.
death receptor activity Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.
oxidoreductase activity, acting on peroxide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.
glucagon receptor activity Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
androgen receptor activity Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II.
rna-directed dna polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate.
magnesium-dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium.
high-density lipoprotein particle receptor binding Interacting selectively and non-covalently with a high-density lipoprotein receptor.
glucose transmembrane transporter activity Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other.
inositol-1,3,4-trisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).
nedd8 transferase activity Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
formimidoyltetrahydrofolate cyclodeaminase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+).
adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3.
receptor signaling protein tyrosine phosphatase activity Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
dna hairpin binding Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.
chenodeoxycholic acid binding Interacting selectively and non-covalently with chenodeoxycholic acid.
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
ribonuclease p rna binding Interacting selectively and non-covalently with the RNA subunit of ribonuclease P.
protein-glutamine n-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine.
nicotinate transporter activity Enables the directed movement of nicotinate into, out of or within a cell, or between cells.
pyrimidine nucleotide binding Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.
cyclohydrolase activity Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring.
glycine n-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.
neuromedin u binding Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses.
interleukin-17e receptor binding Interacting selectively and non-covalently with the interleukin-17E receptor.
bubble dna binding Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.
cholesterol 26-hydroxylase activity Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.
oxidoreductase activity, acting on the ch-oh group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
leukemia inhibitory factor receptor activity Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
creatine kinase activity Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
long-chain acyl-coa hydrolase activity Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length.
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.
calcium-dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
7s rna binding Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP).
oxalate transmembrane transporter activity Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
oxidoreductase activity, acting on the ch-nh2 group of donors, nad or nadp as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
fatty-acyl-coa binding Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
n-acetylglucosamine-1-phosphodiester alpha-n-acetylglucosaminidase activity Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.
udp-n-acetylglucosamine-dolichyl-phosphate n-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
glycerophosphocholine cholinephosphodiesterase activity Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+).
alkenylglycerophosphocholine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde.
ffat motif binding Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.
nucleoside:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione.
1-pyrroline-5-carboxylate dehydrogenase activity Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
l-histidine transmembrane transporter activity Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
beta-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage.
platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.
transcription corepressor activity Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.
map kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
trna binding Interacting selectively and non-covalently with transfer RNA.
peroxisome proliferator activated receptor binding Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.
inositol-1,4,5-trisphosphate 6-kinase activity Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+).
glutamate-trna(gln) ligase activity Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP.
enhancer binding Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
er retention sequence binding Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.
atp-activated nucleotide receptor activity Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP.
sterol binding Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
protein binding involved in cell-cell adhesion Any protein binding that is involved in cell-cell adhesion.
nadphx epimerase activity Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX.
nicotinate-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.
hsp70 protein binding Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
bile acid transmembrane transporter activity Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
polyubiquitin binding Interacting selectively and non-covalently with a polymer of ubiqutin.
protein-glycine ligase activity, initiating Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein.
neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
extracellular matrix structural constituent conferring compression resistance A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.
myosin tail binding Interacting selectively and non-covalently with the tail region of a myosin heavy chain.
l-phenylalanine:pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine.
granulocyte colony-stimulating factor receptor binding Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor.
cardiolipin hydrolase activity Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA).
pyruvate kinase activity Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
atpase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
signaling receptor activity Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
3-hydroxyacyl-coa dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
tocopherol omega-hydroxylase activity Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O .
cytokine binding Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
trans-2-enoyl-coa reductase (nadph) activity Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+.
heparin binding Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
metalloenzyme activator activity Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal.
gtpase activator activity Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
fructose-1-phosphate aldolase activity Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde.
octanoyltransferase activity Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule.
protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
c-8 sterol isomerase activity Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.
gdp-mannose 4,6-dehydratase activity Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O.
growth hormone-releasing hormone receptor activity Combining with growth hormone-releasing hormone to initiate a change in cell activity.
delayed rectifier potassium channel activity Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow.
receptor serine/threonine kinase binding Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity.
protein serine/threonine kinase inhibitor activity Stops, prevents or reduces the activity of a protein serine/threonine kinase.
methylated histone binding Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.
granulocyte macrophage colony-stimulating factor receptor binding Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor.
low-density lipoprotein particle binding Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
complement binding Interacting selectively and non-covalently with any component or product of the complement cascade.
isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
protein-lysine n-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
histamine binding Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
l-malate dehydrogenase activity Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
tetracycline transporter activity Enables the directed movement of tetracycline into, out of or within a cell, or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).
cholecystokinin receptor activity Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone.
double-stranded rna binding Interacting selectively and non-covalently with double-stranded RNA.
mrna 5'-utr binding Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
transcription coactivator binding Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
map kinase phosphatase activity Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate.
arachidonic acid omega-hydroxylase activity Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid.
transcription regulatory region sequence-specific dna binding Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
dimethylargininase activity Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.
bile acid receptor activity Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile.
ryanodine-sensitive calcium-release channel activity Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
porin activity Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
adiponectin binding Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.
histone methyltransferase activity (h3-r2 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3.
deoxycytidine deaminase activity Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3.
amp deaminase activity Catalysis of the reaction: AMP + H2O = IMP + NH3.
6-pyruvoyltetrahydropterin synthase activity Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.
mitochondrial heavy strand promoter anti-sense binding Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA.
dna 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus.
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
alpha-tubulin binding Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.
sulfate adenylyltransferase (atp) activity Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.
dna ligase (atp) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
fructosamine-3-kinase activity Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase.
interleukin-7 binding Interacting selectively and non-covalently with interleukin-7.
voltage-gated sodium channel activity involved in sa node cell action potential Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.
alcohol transmembrane transporter activity Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group.
rna polymerase ii core promoter sequence-specific dna binding transcription factor activity Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
glucosamine 6-phosphate n-acetyltransferase activity Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+).
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.
linear polyubiquitin binding Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next.
nucleotide transmembrane transporter activity Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other.
double-strand/single-strand dna junction binding Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA.
udp-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.
exo-alpha-(2->6)-sialidase activity Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates.
l-glutamine transmembrane transporter activity Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid.
l-ascorbic acid binding Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
double-stranded telomeric dna binding Interacting selectively and non-covalently with double-stranded telomere-associated DNA.
thyroid hormone receptor binding Interacting selectively and non-covalently with a thyroid hormone receptor.
heparan-alpha-glucosaminide n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
p-p-bond-hydrolysis-driven transmembrane transporter activity Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.
cholestenone 5-alpha-reductase activity Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH.
receptor signaling complex scaffold activity Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
camp response element binding Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.
solute:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).
hla-a specific inhibitory mhc class i receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.
l-aspartate:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
mitogen-activated protein kinase p38 binding Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
adenylosuccinate synthase activity Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
isopentenyl-diphosphate delta-isomerase activity Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.
1-acylglycerophosphocholine o-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.
peptide-serine-n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide.
complement component c3a receptor activity Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
hmg box domain binding Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
gamma-tubulin binding Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
pyridoxal kinase activity Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.
amide transmembrane transporter activity Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other.
pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
udp-glucuronate 5'-epimerase activity Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate.
calcium-activated potassium channel activity Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
fatz binding Interacting selectively and non-covalently with a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components.
datp binding Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.
oxidoreductase activity, acting on the ch-nh group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen.
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.
steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative.
g-quadruplex rna binding Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
prostaglandin-d synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2).
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential.
vitamin binding Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
l-threonine transmembrane transporter activity Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid.
tbp-class protein binding Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
oligopeptidase activity Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.
alcohol dehydrogenase [nad(p)+] activity
hepatocyte growth factor receptor binding Interacting selectively and non-covalently with the hepatocyte growth factor receptor.
hyalurononglucosaminidase activity Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
annealing helicase activity Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA).
atp binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
sulfur compound binding Interacting selectively and non-covalently with a sulfur compound.
hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
glycogen (starch) synthase activity Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).
kinase binding Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein-arginine n-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
dna binding, bending The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
neurokinin receptor binding Interacting selectively and non-covalently with a neurokinin receptor.
l-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid.
aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
biotin-[propionyl-coa-carboxylase (atp-hydrolyzing)] ligase activity Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).
complement component c1q binding Interacting selectively and non-covalently with the C1q component of the classical complement cascade.
isg15 transferase activity Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.
dipeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.
beta-aspartyl-peptidase activity Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.
alpha-1,6-mannosylglycoprotein 2-beta-n-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.
c-4 methylsterol oxidase activity Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.
urocanate hydratase activity Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O.
peptidase regulator activity Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
(1->3)-beta-d-glucan binding Interacting selectively and non-covalently with (1->3)-beta-D-glucans.
l-leucine transmembrane transporter activity Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid.
brain-derived neurotrophic factor binding Interacting selectively and non-covalently with brain-derived neurotrophic factor.
lysine n-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue.
peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.
oxysterol 7-alpha-hydroxylase activity Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.
gdp-dissociation inhibitor activity Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
rho gdp-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.
histone methyltransferase activity (h3-r17 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3.
sarcosine dehydrogenase activity Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.
gdp-man:man1glcnac2-pp-dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.
steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.
palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.
ribonuclease t2 activity Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
fatty acid amide hydrolase activity Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid.
hemoglobin binding Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
protein serine/threonine kinase activator activity Increases the activity of a protein serine/threonine kinase.
udp-glucuronic acid transmembrane transporter activity Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin.
galanin receptor binding Interacting selectively and non-covalently with a galanin receptor.
prostaglandin e receptor activity Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
vitamin e binding Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
double-stranded rna adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.
rna polymerase ii regulatory region sequence-specific dna binding Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
calcium oxalate binding Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi.
oleic acid binding Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.
rna polymerase ii core promoter proximal region sequence-specific dna binding transcription factor activity Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.
mhc class ib protein binding Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules.
fatty acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
extracellular-glycine-gated chloride channel activity Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts.
diolein transacylation activity Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein.
orexin receptor activity Combining with orexin to initiate a change in cell activity.
purinergic receptor activity Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
oxytocin receptor activity Combining with oxytocin to initiate a change in cell activity.
dolichyl-diphosphooligosaccharide-protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine.
fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).
succinate-hydroxymethylglutarate coa-transferase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate.
4-hydroxybenzoate decaprenyltransferase activity Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
sterol 12-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.
rna polymerase ii transcription coactivator activity Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.
atp:3'-cytidine-cytidine-trna adenylyltransferase activity Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.
long-chain fatty acid-coa ligase activity Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
alpha-amylase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
small conductance calcium-activated potassium channel activity Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.
trna-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.
phytoceramidase activity Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine.
transferrin receptor activity Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.
radical sam enzyme activity Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical.
lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
omega peptidase activity Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).
rap guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
vascular endothelial growth factor receptor 3 binding Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3.
borate transmembrane transporter activity Catalysis of the transport of borate across a membrane against the concentration gradient.
interleukin-27 binding Interacting selectively and non-covalently with interleukin-27.
beta-adrenergic receptor kinase activity Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.
prenylated protein tyrosine phosphatase activity Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.
eukaryotic initiation factor eif2 binding Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.
voltage-gated chloride channel activity Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
metallodipeptidase activity Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
cyclin-dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
urotensin ii receptor activity Combining with urotensin II to initiate a change in cell activity.
dol-p-man:man(6)glcnac(2)-pp-dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
rrna (adenine-n6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine.
mannose-phosphate guanylyltransferase activity Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule.
vitamin d receptor activator activity Interacting (directly or indirectly) with vitamin D receptors such that the proportion of receptors in the active form is increased.
n-box binding Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
histone deacetylase regulator activity Modulates the activity of histone deacetylase.
myosin heavy chain binding Interacting selectively and non-covalently with a heavy chain of a myosin complex.
g-protein coupled acetylcholine receptor activity Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
transmembrane receptor protein tyrosine phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
hydroxymethylglutaryl-coa synthase activity Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
inositol diphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate.
pseudouridylate synthase activity Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate.
oxidoreductase activity, acting on the ch-nh2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
interleukin-1, type ii, blocking receptor activity Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.
atp-gated ion channel activity Catalysis of the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.
histamine receptor activity Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
branched-chain-amino-acid transaminase activity Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.
type 2 fibroblast growth factor receptor binding Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2).
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.
poly(g) binding Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
protein phosphatase type 1 regulator activity Modulation of the activity of the enzyme protein phosphatase type 1.
inositol monophosphate phosphatase activity Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.
mitochondrial light strand promoter anti-sense binding Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.
aromatic amino acid transmembrane transporter activity Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.
very-long-chain-(s)-2-hydroxy-acid oxidase activity Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons.
xtp diphosphatase activity Catalysis of the reaction: XTP + H2O = xanthosine 5'-phosphate + diphosphate.
phospholipid transporter activity Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
cdp-glycerol diphosphatase activity Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+).
leak channel activity Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.
myosin v binding Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
exo-alpha-(2->3)-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates.
g-quadruplex dna binding Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
endothelin a receptor binding Interacting selectively and non-covalently with an endothelin A receptor.
high-density lipoprotein particle receptor activity Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.
small protein activating enzyme binding Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
nucleosome binding Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
neuropeptide y receptor binding Interacting selectively and non-covalently with a neuropeptide Y receptor.
misfolded protein binding Interacting selectively and non-covalently with a misfolded protein.
cystine:glutamate antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out).
muramyl dipeptide binding Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.
microtubule minus-end binding Interacting selectively and non-covalently with the minus end of a microtubule.
inositol-1,3,4-trisphosphate 1-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.
flap-structured dna binding Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.
[pyruvate dehydrogenase (lipoamide)] phosphatase activity Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.
acetyl-coa hydrolase activity Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
n1-acetylspermine:oxygen oxidoreductase (n1-acetylspermidine-forming) activity Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide.
aspartate-trna(asn) ligase activity Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP.
gtp cyclohydrolase i activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
icosatetraenoic acid binding Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule.
phosphatidylinositol trisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.
corticotropin hormone receptor binding Interacting selectively and non-covalently with a corticotropin hormone receptor.
24-hydroxycholesterol 7alpha-hydroxylase activity Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + H(+) + NADPH + O(2) = (24R)-7alpha,24-dihydroxycholesterol + H(2)O + NADP(+).
protein-malonyllysine demalonylase activity Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
acireductone synthase activity Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
rna polymerase ii repressing transcription factor binding Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
drug transmembrane transporter activity Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
type 5 melanocortin receptor binding Interacting selectively and non-covalently with a type 5 melanocortin receptor.
endothelin b receptor binding Interacting selectively and non-covalently with an endothelin B receptor.
uridine kinase activity Catalysis of the reaction: ATP + uridine = ADP + UMP.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of two atoms of oxygen into one donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor.
camp response element binding protein binding Interacting selectively and non-covalently with the cAMP response element binding protein.
udp-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.
cadmium ion transmembrane transporter activity Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other.
g-protein coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber.
dynein intermediate chain binding Interacting selectively and non-covalently with an intermediate chain of the dynein complex.
water transmembrane transporter activity Enables the directed movement of water (H2O) from one side of a membrane to the other.
structural constituent of tooth enamel The action of a molecule that contributes to the structural integrity of tooth enamel.
uniporter activity Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species.
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
protein serine/threonine phosphatase inhibitor activity Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.
heme transporter activity Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells.
bitter taste receptor activity Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.
acid-ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
biotin-[methylcrotonoyl-coa-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).
phospholipase a2 inhibitor activity Stops, prevents or reduces the activity of the enzyme phospholipase A2.
heme-transporting atpase activity Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out).
arylamine n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
molybdopterin adenylyltransferase activity Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
hedgehog family protein binding Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development.
monosialoganglioside sialyltransferase activity Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP.
jun kinase binding Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
nadh dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
glucosylceramidase activity Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.
rna polymerase ii transcription regulatory region sequence-specific dna binding transcription factor activity involved in negative regulation of transcription Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
choline transmembrane transporter activity Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
n-acetylmuramoyl-l-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.
copii adaptor activity The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way.
deaminase activity Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
c5l2 anaphylatoxin chemotactic receptor binding Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.
o-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.
u4 snrna binding Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA).
cholecystokinin receptor binding Interacting selectively and non-covalently with a cholecystokinin receptor.
alpha-actinin binding Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
protein binding involved in cell adhesion Any protein binding that is involved in cell adhesion.
vitamin d receptor binding Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.
intronic transcription regulatory region sequence-specific dna binding Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within.
superoxide-generating nadph oxidase activity Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.
glyoxalase iii activity Catalysis of the reaction: methylglyoxal + H2O = D-lactate.
rna polymerase ii transcription factor binding Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
protein homodimerization activity Interacting selectively and non-covalently with an identical protein to form a homodimer.
calcium activated cation channel activity Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.
enoyl-[acyl-carrier-protein] reductase (nadph, a-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+.
nadph-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.
neuroligin family protein binding Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.
phenanthrene-9,10-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene.
proton-dependent peptide secondary active transmembrane transporter activity Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.
interleukin-5 receptor activity Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
retinol transporter activity Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.
scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
thyroid hormone transmembrane transporter activity Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
thyroxine 5-deiodinase activity
proline:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).
adrenomedullin receptor activity Combining with adrenomedullin to initiate a change in cell activity.
collagen binding Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
primary active transmembrane transporter activity Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources.
platelet-derived growth factor binding Interacting selectively and non-covalently with platelet-derived growth factor.
cyclic-gmp-amp synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.
inositol tetrakisphosphate kinase activity Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP.
transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).
scaffold protein binding Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
glycine binding Interacting selectively and non-covalently with glycine, aminoethanoic acid.
peptidyl-cysteine s-nitrosylase activity Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein.
gmp synthase activity Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP.
nitrate reductase activity Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.
ubiquinone binding Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units.
sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
dynein heavy chain binding Interacting selectively and non-covalently with a heavy chain of the dynein complex.
arginine n-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue.
ligand-activated rna polymerase ii transcription factor binding transcription factor activity Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.
c-c chemokine receptor activity Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
ionotropic glutamate receptor binding Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
valine-trna ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).
diazepam binding Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium.
platelet-derived growth factor receptor binding Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
cdp-diacylglycerol-inositol 3-phosphatidyltransferase activity Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+).
aminoacyl-trna ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
triose-phosphate isomerase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.
taste receptor activity Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
k63-linked polyubiquitin binding Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers.
transcription factor recruiting transcription factor activity Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.
transmembrane electron transfer carrier Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics.
choline o-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
iduronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains.
dna-3-methylbase glycosylase activity Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site.
23s rrna (adenine(1618)-n(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.
lysine n-acetyltransferase activity, acting on acetyl phosphate as donor Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.
galactosyltransferase activity Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
fumarylacetoacetase activity Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
interferon-gamma binding Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far.
at dna binding Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
sugar transmembrane transporter activity Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides.
trna-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
type 1 fibroblast growth factor receptor binding Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1).
benzodiazepine receptor binding Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR).
methyl-cpnpg binding Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide.
interleukin-1 type i receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.
rna polymerase ii transcription regulatory region sequence-specific dna binding transcription factor activity involved in positive regulation of transcription Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
atp-dependent 5'-3' dna helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
peptidase activity, acting on l-amino acid peptides Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
peroxisomal fatty-acyl-coa transporter activity Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes.
histone demethylase activity (h3-k27 specific) Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
rrna (cytosine-n4-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine.
oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene.
l-ascorbic acid transporter activity Enables the directed movement of L-ascorbate into, out of or within a cell, or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.
lrr domain binding Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.
phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.
follicle-stimulating hormone receptor binding Interacting selectively and non-covalently with a follicle-stimulating hormone receptor.
insulin receptor binding Interacting selectively and non-covalently with the insulin receptor.
follicle-stimulating hormone receptor activity Combining with follicle-stimulating hormone to initiate a change in cell activity.
serpin family protein binding Interacting selectively and non-covalently with any member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a noninhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.
modified amino acid binding Interacting selectively and non-covalently with a modified amino acid.
nucleocytoplasmic transporter activity Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
glyceraldehyde-3-phosphate dehydrogenase (nad+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.
dna replication origin binding Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
l-hydroxyproline transmembrane transporter activity Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein].
g-protein coupled glutamate receptor binding Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor).
alpha-1a adrenergic receptor binding Interacting selectively and non-covalently with an alpha-1A adrenergic receptor.
betaine-homocysteine s-methyltransferase activity Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine.
vitamin transporter activity Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
neuropeptide receptor binding Interacting selectively and non-covalently with a neuropeptide receptor.
phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.
methylmalonyl-coa decarboxylase activity Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.
phosphatidylethanolamine binding Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.
amine binding Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.
l-threonine ammonia-lyase activity Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
ral guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
sulfonylurea receptor binding Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.
quinine 3-monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+).
tubulin-dependent atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.
mitochondrial light strand promoter sense binding Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.
arginyltransferase activity Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.
anion transmembrane transporter activity Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.
long-chain fatty acid binding Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
phosphatidylinositol phospholipase c activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
sumo activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
sodium-dependent phosphate transmembrane transporter activity Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions.
glyoxalase (glycolic acid-forming) activity Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor.
phospholipase a2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
activin-activated receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
calcitonin binding Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.
atg8 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.
glutamic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.
ferrous iron uptake transmembrane transporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in).
high-affinity basic amino acid transmembrane transporter activity Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
phosphatidylinositol-4-phosphate binding Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
retinal isomerase activity Catalysis of the reaction: all-trans-retinal = 11-cis-retinal.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
sumo-specific protease activity Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates.
lipoteichoic acid receptor activity Combining with lipoteichoic acid and transmitting the signal to initiate a change in cell activity.
morphine receptor activity Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.
cation transmembrane transporter activity Catalysis of the transfer of cation from one side of the membrane to the other.
beta-ureidopropionase activity Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.
fibroblast growth factor receptor binding Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).
phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid.
voltage-gated calcium channel activity involved sa node cell action potential Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
adenylate cyclase inhibitor activity Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
interleukin-22 binding Interacting selectively and non-covalently with interleukin-22.
poly(c) rna binding Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule.
biotin-[acetyl-coa-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).
cation-transporting atpase activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
poly(a)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
diphthine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.
n-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.
bile acid binding Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile.
nucleobase binding Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.
heme oxygenase (decyclizing) activity Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O.
fucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose.
[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S.
basic amino acid transmembrane transporter activity Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7.
chemokine (c-c motif) ligand 19 binding Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19.
farnesyl-diphosphate farnesyltransferase activity Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.
histone demethylase activity (h3-trimethyl-k4 specific) Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.
igg receptor activity Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
peroxisome matrix targeting signal-2 binding Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F).
mrna (guanine-n7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
galactosylxylosylprotein 3-beta-galactosyltransferase activity Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP.
mhc class i protein binding Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
interleukin-6 binding Interacting selectively and non-covalently with interleukin-6.
l-ornithine transmembrane transporter activity Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.
peptide-methionine (r)-s-oxide reductase activity Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.
heparan sulfate n-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.
proteinase activated receptor binding Interacting selectively and non-covalently with a proteinase activated receptor.
phosphogluconate dehydrogenase (decarboxylating) activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.
poly(adp-ribose) glycohydrolase activity Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
endopeptidase inhibitor activity Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
nucleic acid transmembrane transporter activity Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information.
rho gtpase binding Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
alpha-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.
endoribonuclease activity, cleaving sirna-paired mrna Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.
peptide:proton symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.
cholesterol monooxygenase (side-chain-cleaving) activity Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
glucuronyl-galactosyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.
acp phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.
single guanine insertion binding Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine.
phosphatidylinositol-4,5-bisphosphate binding Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor.
arginine-trna ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).
succinyl-coa hydrolase activity Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.
nickel cation transmembrane transporter activity Catalysis of the transfer of nickel (Ni) cations from one side of a membrane to the other.
trimethylamine receptor activity Combining with the biogenic amine trimethylamine to initiate a change in cell activity.
inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
gpi anchor binding Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.
adp-activated nucleotide receptor activity Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP.
corticotropin-releasing hormone binding Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland.
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.
immunoglobulin receptor activity Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
ligase activity, forming carbon-sulfur bonds Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
adenine transmembrane transporter activity Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.
myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate.
n-acylphosphatidylethanolamine-specific phospholipase d activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
adrenergic receptor binding Interacting selectively and non-covalently with an adrenergic receptor.
insulin-like growth factor receptor binding Interacting selectively and non-covalently with the insulin-like growth factor receptor.
bradykinin receptor binding Interacting selectively and non-covalently with a bradykinin receptor.
hla-b specific inhibitory mhc class i receptor activity Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
rna 7-methylguanosine cap binding Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
toll-like receptor 2 binding Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
oxidoreductase activity, acting on nad(p)h Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
single-stranded dna-dependent atp-dependent dna helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.
rna-dependent atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.
neurotrophin trkb receptor binding Interacting selectively and non-covalently with the neurotrophin TRKB receptor.
albendazole monooxygenase activity Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+).
sulfur dioxygenase activity Catalysis of the reaction: sulfur + O2 + H2O = sulfite.
glycine n-choloyltransferase activity Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate.
au-rich element binding Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases.
single-stranded dna-dependent atpase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction.
steryl-sulfatase activity Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
fucosylgalactoside 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.
alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.
enzyme activator activity Increases the activity of an enzyme.
methotrexate transporter activity Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
glycerol transmembrane transporter activity Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
calcium-dependent protein kinase regulator activity Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner.
metalloaminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.
chemokine receptor antagonist activity Interacts with chemokine receptors to reduce the action of a chemokine.
glutamine n-acyltransferase activity Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine.
folic acid transporter activity Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
epinephrine binding Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.
histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
clathrin binding Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
disulfide oxidoreductase activity Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
acrosin binding Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.
fas-activated serine/threonine kinase activity Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein.
sour taste receptor activity Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste.
racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid.
serotonin binding Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
leptin receptor binding Interacting selectively and non-covalently with the leptin receptor.
cysteine-type endopeptidase regulator activity involved in apoptotic process Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.
histone deacetylase activity (h4-k16 specific) Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
scavenger receptor binding Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
glycogen binding Interacting selectively and non-covalently with glycogen.
trans-octaprenyltranstransferase activity Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate.
nadp binding
oxidoreductase activity, acting on the ch-oh group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule.
rna polymerase i regulatory region sequence-specific dna binding Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.
single-stranded dna 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.
toxin transporter activity Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
3-beta-hydroxy-delta5-steroid dehydrogenase activity Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).
glycolate oxidase activity Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide.
mads box domain binding Interacting selectively and non-covalently with a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
coenzyme a transmembrane transporter activity Enables the directed movement of coenzyme A across a membrane into, out of or within a cell, or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
enzyme binding Interacting selectively and non-covalently with any enzyme.
oxidized base lesion dna n-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
type 3 galanin receptor binding Interacting selectively and non-covalently with a type 3 galanin receptor.
taurine transmembrane transporter activity Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats.
voltage-gated proton channel activity Catalysis of the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
organic anion transmembrane transporter activity Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
cholesterol 24-hydroxylase activity Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
arachidonate-coa ligase activity Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+).
calcium-dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions.
histone kinase activity (h2a-t120 specific) Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A.
phenanthrene 9,10-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide.
mhc protein complex binding Interacting selectively and non-covalently with the major histocompatibility complex.
siderophore transporter activity Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells.
histone-glutamine methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine.
protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
3-demethylubiquinone-9 3-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.
camp-dependent protein kinase regulator activity Modulation of the activity of the enzyme cAMP-dependent protein kinase.
gtpase binding Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
clathrin heavy chain binding Interacting selectively and non-covalently with a clathrin heavy chain.
phosphatidylinositol 3-kinase binding Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
kdel sequence binding Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
medium-chain-acyl-coa dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
extracellular ligand-gated ion channel activity Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
aspartate-trna ligase activity Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
voltage-gated sodium channel activity involved in av node cell action potential Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
l27 domain binding Interacting selectively and non-covalently with a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.
beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
iron-cytochrome-c reductase activity Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+.
histone kinase activity (h3-t3 specific) Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3.
protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
rna polymerase ii core promoter proximal region sequence-specific dna binding transcription factor activity involved in positive regulation of transcription Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
tfiid-class transcription factor binding Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
ceramide 1-phosphate transporter activity Enables the directed movement of ceramide 1-phosphate into, out of or within a cell, or between cells.
mercury (ii) reductase activity Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH.
cyclic pyranopterin monophosphate synthase activity Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate.
protein complex binding Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
isocitrate dehydrogenase activity Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
(s)-2-hydroxy-acid oxidase activity Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.
transition metal ion binding Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
complement component c4b binding Interacting selectively and non-covalently with the C4b product of the classical complement cascade.
sh3/sh2 adaptor activity Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
transmitter-gated ion channel activity Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.
ornithine decarboxylase activator activity Upregulation of the activity of the enzyme ornithine decarboxylase.
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein].
dgtpase activity Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate.
3',5'-cyclic-amp phosphodiesterase activity Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
udp-n-acetylglucosamine 4-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
creatine transmembrane transporter activity Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.
malonyl-coa synthetase activity Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate.
hormone-sensitive lipase activity Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate.
lysophosphatidic acid receptor activity Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein.
store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
nitric oxide transmembrane transporter activity Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.
trna (adenine-n1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine.
protein-glutamine gamma-glutamyltransferase activity Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
calmodulin binding Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
pre-mrna intronic binding Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).
insulin-like growth factor-activated receptor activity Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
g-protein coupled amine receptor activity Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
interleukin-4 receptor binding Interacting selectively and non-covalently with the interleukin-4 receptor.
phosphatidylcholine-sterol o-acyltransferase activator activity Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines.
channel-conductance-controlling atpase activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
oxidoreductase activity, oxidizing metal ions with flavin as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor.
armadillo repeat domain binding Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.
snrna binding Interacting selectively and non-covalently with a small nuclear RNA (snRNA).
lamin binding Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
quercetin 2,3-dioxygenase activity Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.
myosin ii binding Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin.
phosphatidylcholine-retinol o-acyltransferase activity Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine.
retinoid x receptor binding Interacting selectively and non-covalently with a retinoid X receptor.
magnesium ion transmembrane transporter activity Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other.
histidine ammonia-lyase activity Catalysis of the reaction: L-histidine = urocanate + NH3.
cupric reductase activity Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.
metalloendopeptidase inhibitor activity Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule.
rna uridylyltransferase activity Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).
interleukin-23 receptor binding Interacting selectively and non-covalently with the interleukin-23 receptor.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
mismatch repair complex binding Interacting selectively and non-covalently with a mismatch repair complex.
delta24-sterol reductase activity Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.
toxic substance binding Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
ethanolamine-phosphate phospho-lyase activity Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate.
arsenite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
amino-acid racemase activity Catalysis of the reaction: an L-amino acid = a D-amino acid.
nad-dependent histone deacetylase activity (h3-k14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.
15-hydroxyprostaglandin dehydrogenase (nadp+) activity Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH.
hydrogen ion channel activity Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
ww domain binding Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
ubiquitin-like protein conjugating enzyme activity
transcription corepressor binding Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
mrna binding Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
kynurenine-glyoxylate transaminase activity Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.
oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid.
manganese ion binding Interacting selectively and non-covalently with manganese (Mn) ions.
carbon-nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99).
ion channel inhibitor activity Stops, prevents, or reduces the activity of an ion channel.
rna polymerase ii core promoter sequence-specific dna binding transcription factor activity involved in preinitiation complex assembly Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.
calcium-dependent protein kinase activity Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium.
d-aminoacyl-trna deacylase activity Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA.
interleukin-9 receptor activity Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-.
g-protein coupled receptor kinase activity Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate.
riboflavin kinase activity Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).
omega-amidase activity Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3.
interleukin-6 receptor activity Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
glucose 1-dehydrogenase [nad(p)] activity
transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
cdp-alcohol phosphatidyltransferase activity Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol.
ran guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
card domain binding Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
corticotropin-releasing hormone receptor activity Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.
beta-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage.
g-protein activated inward rectifier potassium channel activity Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
alpha-methylacyl-coa racemase activity Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.
[heparan sulfate]-glucosamine n-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.
c-c motif chemokine 19 receptor activity Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
protein phosphatase binding Interacting selectively and non-covalently with any protein phosphatase.
oligo-1,6-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose.
signal sequence binding Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
bile-salt sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond.
triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
fatty-acyl-coa transporter activity Enables the directed movement of a fatty acyl CoA group into, out of or within a cell, or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it.
ankyrin repeat binding Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
ganglioside binding Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.
alditol:nadp+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
lipoprotein lipase activator activity Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.
gtp diphosphatase activity Catalysis of the reaction: GTP + H2O = GMP + diphosphate.
threonine-trna ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
nad+ binding
glucose-6-phosphate transmembrane transporter activity Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
inositol tetrakisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).
intracellular cyclic nucleotide activated cation channel activity Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
atpase activity, coupled to transmembrane movement of ions, rotational mechanism Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism.
rrna (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine.
diphosphomevalonate decarboxylase activity Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.
oxidoreductase activity, acting on the ch-ch group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
anion:anion antiporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
interleukin-10 receptor activity Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
sterol o-acyltransferase activity Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.
cyclo-ligase activity Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
n-acylneuraminate-9-phosphatase activity Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate.
hydroxymethyl-, formyl- and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).
d-glucose transmembrane transporter activity Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other.
sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8.
carboxyl-o-methyltransferase activity Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester.
deoxynucleoside kinase activity Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.
nucleosomal histone binding Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
xylulokinase activity Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+).
n(1),n(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine.
map kinase tyrosine/serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.
atp-dependent 5'-3' dna/rna helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'.
glycerone-phosphate o-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA.
lactosylceramide 1,3-n-acetyl-beta-d-glucosaminyltransferase activity Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP.
vitamin transmembrane transporter activity Enables the transfer of a vitamin from one side of a membrane to the other.
protein kinase a regulatory subunit binding Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.
n,n-dimethylaniline monooxygenase activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
inositol-polyphosphate 5-phosphatase activity Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
serine c-palmitoyltransferase activity Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
arylesterase activity Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.
n-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
inorganic diphosphatase activity Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate.
alpha-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase.
clathrin light chain binding Interacting selectively and non-covalently with a clathrin light chain.
sam domain binding Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.
copper ion binding Interacting selectively and non-covalently with copper (Cu) ions.
insulin-activated receptor activity Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity.
galactosylceramide sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
tap1 binding Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein.
propionyl-coa carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
8-hydroxy-dadp phosphatase activity Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.
oxidoreductase activity, acting on ch or ch2 groups Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
growth factor binding Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
unfolded protein binding Interacting selectively and non-covalently with an unfolded protein.
core promoter sequence-specific dna binding Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
alcohol dehydrogenase activity, zinc-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.
receptor signaling protein serine/threonine phosphatase activity Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
beta-alanine-pyruvate transaminase activity Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine.
volume-sensitive chloride channel activity Catalysis of the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
cholesterol transporter activity Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
peroxisome targeting sequence binding Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome.
endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
glycine-trna ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
receptor regulator activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.
sulfide:quinone oxidoreductase activity Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone.
carboxylic acid transmembrane transporter activity Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
2-aminoadipate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products.
arachidonic acid 11,12-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid.
c-x3-c chemokine receptor activity Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
transcription termination site dna binding Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.
[methionine synthase] reductase activity Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.
nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.
adenosylhomocysteinase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.
phosphoribosylaminoimidazole carboxylase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
polyribonucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA.
cyclic nucleotide-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide.
electron-transferring-flavoprotein dehydrogenase activity Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol.
l-phenylalanine aminotransferase activity Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid.
integrin binding Interacting selectively and non-covalently with an integrin.
prosthetic group binding Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
calcium- and calmodulin-regulated 3',5'-cyclic-gmp phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive.
l-phenylalanine-oxaloacetate transaminase activity Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate.
chitin binding Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
oxidized pyrimidine nucleobase lesion dna n-glycosylase activity Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
protein n-terminus binding Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
polymeric immunoglobulin receptor activity Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
2-alkenal reductase [nad(p)] activity
globoside alpha-n-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP.
udp-n-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.
dna-n1-methyladenine dioxygenase activity Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
tap2 binding Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein.
calcium-induced calcium release activity Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration.
sumo conjugating enzyme activity Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.
eukaryotic translation initiation factor 2alpha kinase activity Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate.
glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
adp-ribosylation factor binding Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.
anion channel activity Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
nad+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.
peptide-glutamate-n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide.
diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.
uridine-diphosphatase activity Catalysis of the reaction: UDP + H2O = UMP + phosphate.
phosphatidylcholine 1-acylhydrolase activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
carbohydrate binding Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
oxoglutarate dehydrogenase (nad+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.
phosphothreonine binding Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein.
myosin-light-chain-phosphatase activity Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.
ribonucleoprotein complex binding Interacting selectively and non-covalently with any complex of RNA and protein.
extracellular matrix constituent, lubricant activity Functions as a lubricant for an extracellular matrix, such as a mucous membrane.
n-terminal protein n-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
citrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
bisphosphoglycerate phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate.
phosphatase regulator activity Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
dol-p-man:man(5)glcnac(2)-pp-dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
sequence-specific transcription regulatory region dna binding rna polymerase ii transcription factor recruiting transcription factor activity Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II.
l-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.
dolichyl-phosphate beta-d-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
sphingomyelin phosphodiesterase activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
n-acylglucosamine 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.
inorganic cation transmembrane transporter activity Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
collagen v binding Interacting selectively and non-covalently with a type V collagen trimer.
mhc class i receptor activity Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
udp-n-acetylglucosamine diphosphorylase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.
interleukin-23 binding Interacting selectively and non-covalently with interleukin-23.
folic acid binding Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
guanine/thymine mispair binding Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair.
saccharopine dehydrogenase (nad+, l-glutamate-forming) activity Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
nitric oxide binding Interacting selectively and non-covalently with nitric oxide (NO).
pristanate-coa ligase activity Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA.
butyrate-coa ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
insulin-like growth factor binding Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
chylomicron binding Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE.
l-fuconate dehydratase activity Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O.
formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH.
histone methyltransferase activity (h4-r3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
3-dehydrosphinganine reductase activity Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH.
heparan sulfate sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate.
chloride transmembrane transporter activity Catalysis of the transfer of chloride ions from one side of a membrane to the other.
morphogen activity Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.
complement component c3b receptor activity Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
monocarboxylic acid binding Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-).
organic cation transmembrane transporter activity Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.
glucuronosyl-n-acetylglucosaminyl-proteoglycan 4-alpha-n-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.
organic hydroxy compound transmembrane transporter activity Catalysis of the transfer of organic hydroxy compound from one side of the membrane to the other.
ctd phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate.
potassium channel inhibitor activity Stops, prevents, or reduces the activity of a potassium channel.
squalene synthase activity Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate.
dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+).
phosphatidyl-n-dimethylethanolamine n-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine.
glutaminyl-peptide cyclotransferase activity Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.
fucosidase activity Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative.
asparaginase activity Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.
udp-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.
gmp synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.
cytochrome-b5 reductase activity, acting on nad(p)h
regulatory region nucleic acid binding Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
peroxidase inhibitor activity Interacts with, and stops, prevents or reduces the activity of a peroxidase.
thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
iga binding Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype.
udp-n-acetylglucosamine 2-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.
gaf domain binding Interacting selectively and non-covalently with the GAF domain of a protein.
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
actin binding Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters.
spermine:oxygen oxidoreductase (spermidine-forming) activity Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine.
sulfur-containing amino acid secondary active transmembrane transporter activity Catalysis of the transfer of sulfur-containing amino acid from one side of the membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
endoplasmic reticulum signal peptide binding Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
glucocorticoid-activated rna polymerase ii transcription factor binding transcription factor activity Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements.
histone methyltransferase activity (h3-k36 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
glutaryl-coa dehydrogenase activity Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.
ap-2 adaptor complex binding Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
prostaglandin-i synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
mitogen-activated protein kinase kinase binding Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
ubiquitin-like protein-specific isopeptidase activity
dna secondary structure binding Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions.
alpha-l-fucosidase activity Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.
laminin receptor activity Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.
proline racemase activity Catalysis of the reaction: L-proline = D-proline.
glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
3'-5' dna helicase activity Catalysis of the unwinding of the DNA helix in the direction 3' to 5'.
mitochondrial ribosome binding Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell.
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.
bmp binding Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
transferrin receptor binding Interacting selectively and non-covalently with the transferrin receptor.
adp-sugar diphosphatase activity Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate.
chitobiosyldiphosphodolichol beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol.
biotin-protein ligase activity Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein.
neutral amino acid transmembrane transporter activity Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7.
peptide-n4-(n-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.
galactosylgalactosylglucosylceramide beta-d-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide.
gamma-glutamyl-peptidase activity Catalysis of the cleavage of a gamma-linked glutamate bond.
lysophosphatidic acid binding Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors.
acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
k6-linked polyubiquitin binding Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers.
peptidyl-dipeptidase inhibitor activity Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain.
u3 snorna binding Interacting selectively and non-covalently with U3 small nucleolar RNA.
extracellular matrix binding Interacting selectively and non-covalently with a component of the extracellular matrix.
norepinephrine binding Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
aspartate oxidase activity Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide.
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.
androsterone dehydrogenase activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione.
pantetheine-phosphate adenylyltransferase activity Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate.
isg15-specific protease activity Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates.
toxin receptor binding Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms.
inositol-1,3,4-trisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
rrna (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine.
long-chain-alcohol oxidase activity Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O.
laminin binding Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
dol-p-man:man(8)glcnac(2)-pp-dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
glycine dehydrogenase (decarboxylating) activity Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.
apolipoprotein a-i receptor binding Interacting selectively and non-covalently with an apolipoprotein A-I receptor.
histone kinase activity (h3-t11 specific) Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.
water channel activity Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
syndecan binding Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
protein binding involved in heterotypic cell-cell adhesion Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
interleukin-1 receptor binding Interacting selectively and non-covalently with the interleukin-1 receptor.
acetyl-coa c-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
monosaccharide binding Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
inorganic diphosphate transmembrane transporter activity Catalysis of the transfer of inorganic diphosphate across a membrane.
pyruvate transmembrane transporter activity Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other.
beta-galactoside (cmp) alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.
stem cell factor receptor binding Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
intramolecular oxidoreductase activity, transposing c=c bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.
mismatched dna binding Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
protein tyrosine kinase collagen receptor activity Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
bile acid:sodium symporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).
trna dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine.
patched binding Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.
epidermal growth factor-activated receptor activity Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
microsatellite binding Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.
utp binding Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.
nucleoside phosphate binding Interacting selectively and non-covalently with nucleoside phosphate.
ribonuclease iii activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
interleukin-18 binding Interacting selectively and non-covalently with interleukin-18.
dna ligase activity Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.
beta2-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors.
vascular endothelial growth factor binding Interacting selectively and non-covalently with a vascular endothelial growth factor.
protein phosphorylated amino acid binding Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.
beta-galactosyl-n-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide.
rna polymerase binding Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
interleukin-8 binding Interacting selectively and non-covalently with interleukin-8.
ferric-chelate reductase (nadph) activity Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ .
dystroglycan binding Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).
melanocortin receptor binding Interacting selectively and non-covalently with a melanocortin receptor.
trna (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine.
all-trans retinal binding Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A.
phytanate-coa ligase activity Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA.
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate.
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide.
adp-specific glucokinase activity Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate.
6,7-dihydropteridine reductase activity Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.
translation repressor activity Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
l-amino acid transmembrane transporter activity Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids.
6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
phosphoacetylglucosamine mutase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.
peptidyl-proline 3-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.
prostaglandin-e synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).
spermidine binding Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate.
l-iditol 2-dehydrogenase activity Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
uracil dna n-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
sequence-specific dna binding transcription factor recruiting transcription factor activity The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.
importin-alpha export receptor activity Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm.
hydrolase activity, acting on ether bonds Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively.
betaine-aldehyde dehydrogenase activity Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.
erythropoietin receptor binding Interacting selectively and non-covalently with the erythropoietin receptor.
protease binding Interacting selectively and non-covalently with any protease or peptidase.
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
protein self-association Interacting selectively and non-covalently with a domain within the same polypeptide.
dutp diphosphatase activity Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
mannosyl-glycoprotein endo-beta-n-acetylglucosaminidase activity Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.
cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
apolipoprotein binding Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
glutamate dehydrogenase (nad+) activity Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.
oxidoreductase activity, acting on other nitrogenous compounds as donors Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
rna polymerase iii transcription factor binding Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III.
arachidonic acid binding Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
hydroxyacid-oxoacid transhydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.
a1 adenosine receptor binding Interacting selectively and non-covalently with an A1 adenosine receptor.
isoleucine-trna ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
testosterone 17-beta-dehydrogenase (nadp+) activity Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.
acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule.
3 iron, 4 sulfur cluster binding Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing.
ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.
n4-(beta-n-acetylglucosaminyl)-l-asparaginase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).
oxidoreductase activity, oxidizing metal ions, nad or nadp as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor.
calcium ion binding Interacting selectively and non-covalently with calcium ions (Ca2+).
ciliary neurotrophic factor receptor activity Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
carbohydrate response element binding Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.
ubiquitin binding Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
2 iron, 2 sulfur cluster binding Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
structural constituent of eye lens The action of a molecule that contributes to the structural integrity of the lens of an eye.
copper uptake transmembrane transporter activity Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in).
interleukin-6 receptor binding Interacting selectively and non-covalently with the interleukin-6 receptor.
trace-amine receptor activity Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.
aminocarboxymuconate-semialdehyde decarboxylase activity Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2).
host cell surface receptor binding Interacting selectively and non-covalently with a receptor on the host cell surface.
organophosphate ester transmembrane transporter activity Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds.
taurine binding Interacting selectively and non-covalently with taurine.
hormone receptor binding Interacting selectively and non-covalently with a receptor for hormones.
serine binding Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid.
l-xylulose reductase (nadp+) activity Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH.
protein-disulfide reductase (glutathione) activity Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol.
acetyl-coa:l-glutamate n-acetyltransferase activity Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).
alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.
rna polymerase ii basal transcription factor binding Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
tryptamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+.
oncostatin-m receptor activity Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
glycerol kinase activity Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).
corticotropin-releasing hormone receptor 1 binding Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system.
oxygen sensor activity Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.
cd27 receptor binding Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
minus-end directed microfilament motor activity Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers.
(alpha-n-acetylneuraminyl-2,3-beta-galactosyl-1,3)-n-acetyl-galactosaminide 6-alpha-sialyltransferase activity Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP.
calcium-dependent phospholipase c activity Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.
peptide alpha-n-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
ph domain binding Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
ubiquitin conjugating enzyme binding Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
ccr7 chemokine receptor binding Interacting selectively and non-covalently with a CCR7 chemokine receptor.
histone deacetylase inhibitor activity Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.
histone acetyltransferase activity (h4-k5 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).
glucan 1,4-alpha-glucosidase activity Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.
neurotrophin p75 receptor binding Interacting selectively and non-covalently with the neurotrophin p75 receptor.
transketolase activity Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.
interleukin-10 receptor binding Interacting selectively and non-covalently with the interleukin-10 receptor.
purine ribonucleoside triphosphate binding Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
rna polymerase i core element sequence-specific dna binding Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
mrna 3'-utr au-rich region binding Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
protein disulfide oxidoreductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.
malonate-semialdehyde dehydrogenase (acetylating) activity Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
calcidiol 1-monooxygenase activity Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
formate transmembrane transporter activity Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.
phosphatidylinositol 3-kinase catalytic subunit binding Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
4 iron, 4 sulfur cluster binding Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
dna-7-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.
nucleobase transmembrane transporter activity Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.
3-oxoacyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].
ribosylnicotinamide kinase activity Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide.
inorganic phosphate transmembrane transporter activity Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
tumor necrosis factor receptor superfamily binding Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
ligase activity, forming phosphoric ester bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
long-chain-alcohol o-fatty-acyltransferase activity Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA.
aldo-keto reductase (nadp) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
delta-catenin binding Interacting selectively and non-covalently with the delta subunit of the catenin complex.
inositol oxygenase activity Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+).