CORUM Protein Complexes Dataset

Description proteins participating in complexes by manual literature curation
Measurement association by literature curation
Association protein-protein complex associations from curated complexes
Category structural or functional annotations
Resource CORUM
Citation(s)
Last Updated
Stats
  1. 2799 genes
  2. 2075 protein complexs
  3. 9015 gene-protein complex associations

Data Access

API
Script

Visualizations

  • Attribute Similarity

  • Dataset

  • Gene Similarity

protein complex Gene Sets

2075 sets of proteins in protein complexes from the CORUM Protein Complexes dataset.

Gene Set Description
(C-CFTR)2-NHERF-ezrin complex
(E.F.G) complex A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex.
(ER)-localized multiprotein complex, Ig heavy chains associated
(ER)-localized multiprotein complex, in absence of Ig heavy chains
12S U11 snRNP
13S condensin complex A multisubunit protein complex that plays a central role in chromosome condensation.
17S U2 snRNP
18S U11/U12 snRNP
20S methylosome and RG-containing Sm protein complex
20S methylosome-SmD complex
20S methyltransferase complex A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
20S methyltransferase core complex
20S proteasome
26S proteasome
28S ribosomal subunit, mitochondrial
2AR-mGluR2 complex
39S ribosomal subunit, mitochondrial The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
40S ribosomal subunit, cytoplasmic
53BP1-containing complex
55S ribosome, mitochondrial A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
5S-DNA-TFIIIA-TFIIIC2 subcomplex
5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex
60S APC containing complex
60S ribosomal subunit, cytoplasmic
6S methyltransferase and RG-containing Sm proteins complex
6S methyltransferase complex
6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex
9-1-1 complex
9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex
Abcg5-Abcg1 complex
Abcg5-Abcg2 complex
Abcg5-Abcg4 complex
Abcg5-Abcg8 complex
Abcg8-Abcg4 complex
ABI1-WASF2 complex
ABI1-WASL complex
ABIN2-NFKB1-MAP3K8 complex A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.
ABL2-HRAS-RIN1 complex
Acinar cell-specific C complex A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.
ACT homodimer complex
ACT-CREB complex
Actin-ribonucleoprotein complex (POLR2A, GTF2F1, HNRNPU)
ActRIIA-ActRIB-Smad3-Arip1 complex
ADAR1-CDK2 complex
Adiponectin homohexamer complex
Adiponectin homotrimer complex
ADRB2 homodimer complex
AFF1-MLLT1-CBX8 complex
Affixin-actinin(alpha) complex
Agap11-AP3 complex
AGO2-FXR1-TNF(alpha)ARE-RNP complex
AGPS-GNPAT complex
Agtr1a-Jak2 complex
AIF-CYPA-DNA complex
Aip-Hsp90-Ahr complex
AIRE homodimer complex
AK2-FADD-caspase-10 (AFAC10) complex
AKAP250-PKA-PDE4D complex
ALL-1 supercomplex
AMY-1-S-AKAP84-RII-beta complex
Amyloid beta protein oligomer
Anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
ANCO1-HDAC3 complex
Angiomotin isoform p80-Angiostatin complex
anti-BHC110 complex
Anti-HDAC2 complex
Anti-Sm protein complex
Anti-SMN protein complex
AOF2-AR complex
AP1 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
AP1G1-PACS1-FURIN complex
AP3 adapter complex
AP3-BLOC1 complex
AP3D1-AP3S1 complex
AP3D1-AP3S2 complex
AP4 adaptor complex An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.
Apaf1 homo-oligomer complex
APC-Axin-1-beta-catenin complex A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
APC-DLG4 complex
Apg16L-Apg12-Apg5 complex
APH1A-PSEN1-NCSTN complex
APH1A-PSEN2-NCSTN complex
APLG1-Rababtin5 complex
Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18-RNPS1-Acinus-L
Apoptosis- and splicing-associated protein complex (ASAP-S), SAP18-RNPS1-Acinus-S
Apoptosome A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.
Apoptosome-procaspase 9 complex
APP-FE65-LRP complex
APP-TIMM23 complex
APP-TOMM40 complex
APPBP1-UBA3 complex
AR coactivator complex
AR-AKT-APPL complex
ARC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.
ARC-L complex
ARC92-Mediator complex
ARD1-NATH complex
ARF-Mule complex
ArgBP2a-CBL-PTK2B complex
ARNT-HIF1A complex
ARNT-HLF complex
Arnt-Sim1 complex
Arnt-Sim2 complex
Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
Artemis-DNA-PK complex
ASCOM complex
ASF1-histone containing complex
ASF1-interacting protein complex
Ask1-Traf6 complex, LPS induced
ASPP1-SAM68 complex
ATM homodimer complex
ATM-NBS1 complex
ATP-utilizing chromatin assembly and remodeling factor (hACF) complex
ATR-ATRIP complex A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.
ATR-HDAC2 complex
ATR-HDAC2-CHD4 complex
ATRX-DAXX complex
AXIN-APC-betaCatenin-GSK3B complex A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Axin-Dvl-Gsk complex
Axin-Dvl-Gsk-Frat1 complex
Axin-Mekk4 complex
AXIN-MEKK4-CCD1 complex
Axin-p53-HIPK2 complex
Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
Axin-SMAD3 complex
Axin2-Ctnnb1-Apc complex
AXL homodimer complex
B-Ksr1-MEK-MAPK-14-3-3 complex
B-raf-MAP3K11 complex
B23-NPM3 complex
BAD-BCL2xL complex
Bad-Gk-Wave1-Pkaca-Ppp1cc complex
BAF complex
BANF1 homodimer protein
BAR-BCL2-CASP8 complex
BARD1-BRCA1-CSTF complex
BARD1-BRCA1-CSTF64 complex
BASC (Ab 80) complex (BRCA1-associated genome surveillance complex)
BASC (Ab 81) complex (BRCA1-associated genome surveillance complex)
BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex)
BASC complex (BRCA1-associated genome surveillance complex)
Bash-Bnas2/Cmtm3-Btk-Erk2 complex
BAX homo-oligomer complex
Bax homooligomeric complex, after apoptotic stimulation
BAX-BAK-IRE1alpha complex
BCDX2 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.
Bcl-xL-p53-PUMA complex, DNA damage induced
BCL10 oligomer complex
BCL10-CHUK-BCL10-IKBKB complex
BCL10-MALT1 complex
Bcl2 homodimer complex
BCL6-HDAC4 complex
BCL6-HDAC5 complex
BCL6-HDAC7 complex
BCL6-ZBTB17 complex
BCOR complex
BCR-ABL (p185 fusion protein)-GRB2 complex
BCR-ABL (p210 fusion protein)-GRB2 complex
BCR-ABL (p210 fusion protein)-GRB2-SOS1 complex
beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A)
Beta-dystroglycan-caveolin-3 complex
BETA2-Cyclin D1 complex
BHC complex
BHC110 complex
Binary COG subcomplex
Bipartite complex (TFC4, CTNNB1)
BIRC5-AURKB-INCENP-EVI5 complex
Birc6 homodimer complex
BKCA-beta2AR complex
BKCA-beta2AR-AKAP79 signaling complex
BLM complex II
BLM complex III
BLM-RAD51L3-XRCC2 complex
BLM-TOP3A complex
BLM-TRF2 complex
BLOC-1 (biogenesis of lysosome-related organelles complex 1)
BLOC-2 (biogenesis of lysosome-related organelles complex 2)
BLOC-3 (biogenesis of lysosome-related organelles complex 3)
BLOC1-BLOC2 complex
BMI1-HPH1-HPH2 complex
Bmi1-Mel18-Mph1-M33 polycomb repressor complex
BMP2-BRIA complex
BMP4-BGN complex
BMP4-TWSG1 complex
BNIP2-ARHGAP8 complex
BP-SMAD complex
BRAF-CNK1 complex, not RAS stimulated
BRAF-MAP2K1-MAP2K2-YWHAE complex
BRAF-RAF1-14-3-3 complex
BRAF53-BRCA2 complex
BRAFT complex
Brain-derived dystrobrevin-syntrophin complex
BRCA1 A complex A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
BRCA1 B complex A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
BRCA1 C complex A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
BRCA1-BACH1 complex
BRCA1-BARD1-BACH1-DNA damage complex I
BRCA1-BARD1-BACH1-DNA damage complex II
BRCA1-BARD1-BRCA2-DNA damage complex III
BRCA1-BARD1-POLR2A complex
BRCA1-BARD1-UbcH5c complex
BRCA1-BARD1-UbcH7c complex
BRCA1-cABL complex
BRCA1-core RNA polymerase II complex
BRCA1-CtIP-CtBP complex
BRCA1-CTIP-ZBRK1 repressor complex
BRCA1-HDAC1-HDAC2 complex
BRCA1-IRIS-pre-replication complex
BRCA1-LMO4-CTIP complex
BRCA1-RAD50-MRE11-NBS1 complex
BRCA1-RAD51 complex A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.
BRCA1-RNA polymerase II complex
BRCA1-SMAD3 complex
BRCA1-VCP complex
BRCC complex
BRD4 complex
BRD4-P-TEFb complex
BRD4-RFC complex
BRG1-associated complex
Brg1-associated complex I
Brg1-associated complex II
Brg1-based SWI/SNF chromatin remodeling complex
BRG1-SIN3A complex
BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I
Brm-associated complex
BRM-SIN3A complex
BRM-SIN3A-HDAC complex
BRMS1-RBP1 complex
BRMS1-SIN3-HDAC complex
BUB1-BUB3 complex Protein complex that associates with the kinetochores.
C complex spliceosome
C-CFTR-NHERF(PDZ1 domain)-ezrin complex
C-CFTR-NHERF(PDZ2 domain)-ezrin complex
c-MYC-ATPase-helicase complex
c-Myc-Max-Arf complex
c-Src-Muc1 complex
C/EBPalpha-HNF6 complex
C1D homodimer protein
CACY homodimer complex
CAK complex (Cdk-activating kinase complex)
CAK core complex (Cdk-activating kinase core complex)
CAK-ERCC2 complex A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.
CALM1-FKBP38-BCL2 complex
Calreticulin oligomer complex
CAMK2-delta-MASH1 promoter-coactivator complex
CAND1-CUL1-RBX1 complex
CAND1-CUL2-RBX1 complex
CAND1-CUL3-RBX1 complex
CAND1-CUL4A-RBX1 complex
CAND1-CUL4B-RBX1 complex
CAP(C)-CAP(E) complex
Car-Jam3 complex
Car-Lnx2 complex
CARMA1-BCL10-MALT1 complex A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.
CAS-SRC-FAK complex
Casein kinase II (beta-dimer, alpha'-dimer)
Casein kinase II (beta-dimer, alpha, alpha')
Casein kinase II (beta-dimer, alpha-dimer)
Casein kinase II complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.
Casein kinase II-HMG1 complex
Cask-Dlg1 complex
CASK-LIN7C-APBA1 complex
CASK-MINT complex
CASP8-CHUK-IKBKB-MALT1-BCL10 complex
CASP8-FADD-MALT1-BCL10 complex
Caspase-2-TRAF2-RIP1 complex
Catenin (alpha) - catenin (beta) complex
Catulin (alpha) - catenin (beta) complex
CAV1-VDAC1-ESR1 complex
Caveolar macromolecular signaling complex A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).
Caveolar macromolecular signaling complex, using anti-Cav-3
Caveolin-1 homodimer complex
CBC complex (cap binding complex)
CBF-DNA complex
CBF1-HDAC1-SMRT complex
Cbl-Cd2ap complex
Cbl-Cd2ap-Flt1 complex
Cbl-Crkl-Rapgef1 complex
Cbl-SLP-76-Grb2 complex, Fc receptor gamma-R1 stimulated
CBP-RARA-RXRA-DNA complex, ligand stimulated
Ccd1-Axin complex
Ccd1-Dvl2 complex
Ccd1-Dvl2-Rac complex
Ccd1-Mekk4 complex
Ccna2-Cdk2 complex
CCNB1-CDC2 complex
CCNB2-CDC2 complex
CCNC-CDK3 complex
CCNC-CDK8-MED1-MED6-MED7 xcomplex
CCND1-CDK4 complex
CCND1-CDK6 complex
CCND2-CDK4 complex
CCND2-CDK6 complex
CCND3-CDK4 complex
CCND3-CDK6 complex
CCT complex (chaperonin containing TCP1 complex)
CCT complex (chaperonin containing TCP1 complex), testis specific
CCT micro-complex
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
CD19-Vav-PI 3-kinase (p85 subunit) complex A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).
CD20-LCK-FYN-p75/80 complex
CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line)
Cd247 homodimer complex
CD28-transactivation complex
Cd2ap-Fyn complex
Cd2ap-Synpo complex
Cd3d-Cd3g-Cd3e-Cd247 complex
Cd3e homodimer complex
Cd3e-Nck1-Mink1 complex
Cd3g-Cd3e complex
Cd3g-Cd3e-Cd247-Canx complex
Cd74-Cd44 receptor complex
CD8A-LCK complex
CD98-LAT2-ITGB1 complex
CDC2-CCNA2 complex
CDC2-CCNA2-CDK2 complex
Cdc2-Ccnb1 complex
CDC2-CCNB1-CCNF complex
CDC2-CCNB1-PTCH1 complex
CDC2-PCNA-CCNB1-GADD45A complex
CDC2-PCNA-CCNB1-GADD45B complex
CDC2-PCNA-CCNB1-GADD45G complex
CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex
CDC5L complex
CDC5L core complex
CDC7-DBF7 complex
CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex
CDH1-CKS1B complex
CDH1-SKP2 complex
CDH23-harmonin transmembrane complex
Cdh23-Myo1c complex
CDK2-CCNA2 complex
CDK2-CCNE1 complex
CDK4-CCND1 complex
Cdk5-c-Abl-Cables complex
Cdk5-Cdk5r1-Pctk1 complex
Cdk5/p35 complex (Cdk5-Cdk5r1 complex)
CDK8-CyclinC-Mediator complex
CDK8-MED6-PARP1 complex
Cebpa-Smarca2 complex
CEBPE-E2F1-RB1 complex
Cell cycle kinase complex CDC2
Cell cycle kinase complex CDK2
Cell cycle kinase complex CDK4
Cell cycle kinase complex CDK5
Cell division cycle complex (CDC27, CDC16, ANAPC7)
Cell-cell junction complex (ARHGAP10-CTNNA1)
Cell-cell junction complex (CDH1-CTNNB1)
CEN complex
CENP-A NAC-CAD complex
CENP-A nucleosome associated complex
CERF complex (CECR2-containing remodeling factor complex)
CF IIAm complex (Cleavage factor IIAm complex)
CFTR-NHERF-beta(2)AR signaling complex
Channel complex TRPM6-TRPM7
Checkpoint 9-1-1 complex
Checkpoint Rad complex
CHL12-RFC2-5 complex
CHL2-BMP2 complex
CHL2-BMP2-TSG complex
Chromatin assembly complex (CAF-1 complex)
Chromatin remodeling complex (TACC2, TACC3, PCAF)
Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5)
Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB)
Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5)
Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)
CHUK-ERC1-IKBKB-IKBKG
CHUK-IKBKB-IKBKG complex
CHUK-IKBKB-MAP3K14 complex
CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex
CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex
CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1)
CIN85 homotetramer complex
CIN85-BLNK complex
CIN85-c-CBL complex
CIN85-CBL complex
CIN85-CBL-SH3GL2 complex
CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated
CIN85-SH3GL2 complex
CIN85-SH3GL3 complex
CIN85-SH3GL3-CBL complex
Class C Vps complex (VPS11, VPS18, STX7)
Class C Vps complex (VPS11, VPS18, VPS16)
Class C VPS/HOPS complex
Cleavage and polyadenylation factor (CPSF)
Cleavage stimulation factor
ClpP complex, heptameric
ClpX complex, hexameric
ClpXP complex
cMYC-ATPase-helicase complex
CNK1 homodimer complex
CNK1-SRC-RAF1 complex
CNS-P53 complex
CNTF-CNTFR-gp130-LIFR complex
Cofilin-actin-CAP1 complex
COG complex A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p).
COG1-COG8 subcomplex
COG1-COG8-COG2-COG3-COG4 subcomplex
COG1-COG8-COG5-COG6-COG7 subcomplex
COG2-COG3-COG4 subcomplex
COG5-COG6-COG7 subcomplex
Cohesin complex, incomplete (Rec8, Crest/Ss18I1)
Cohesin complex, incomplete (Smc1b, Crest/Ss18I1)
Cohesin complex, incomplete (Smc1b, Sycp1, Crest/Ss18I1)
Cohesin complex, incomplete (Smc3, Sycp1, Crest/Ss18I1)
Cohesin complex, incomplete (Smc4, Crest/Ss18I1)
Cohesin complex, incomplete (Stag3, Crest/Ss18I1)
Cohesin complex, incomplete (Stag3, Scp1, Ss181)
Cohesin complex, incomplete (Stag3, Sycp3)
Cohesin complex, incomplete (Sycp1, Crest/Ss18I1, Rec8)
Cohesin complex, incomplete (Sycp2, Crest/Ss18I1)
Cohesin-SA1 complex
Cohesin-SA2 complex
Complexin complex (STX3, CPLX1, CPLX3)
Condensin I complex
Condensin I-PARP-1-XRCC1 complex
Condensin II
Conserved oligomeric Golgi (COG) complex
COP9 signalosome complex
COP9 signalosome complex (Gps1, Cops1, Cops2, Cops3, Cops4, Cops5, Cops6, Cops7a, Cops7b, Cops8)
CoREST-HDAC complex
CoREST-HDAC2 complex
COX1 homodimer complex
CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex
CPSF6-ITCH-NUDT21-POLR2A complex
CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex
CRB1-MPP5-INADL complex
Crb1-Mupp1-Pals1-Mpp4 complex
CREBBP-SMAD2 hexameric complex
CREBBP-SMAD2-SMAD4 pentameric complex
CREBBP-SMAD3 hexameric complex
CREBBP-SMAD3-SMAD4 pentameric complex
cRET-Shc-Grb2-Gab2-P85PI3K-Shp2 complex
CRK-BCAR1-DOCK1 complex
CRKII-C3G complex
CRKL-PDGFRA-CRK-RAPGEF1 complex
CRKL-WIPF1-WAS complex
CRLR-RAMP1 complex
CRLR-RAMP2 complex
CRLR-RAMP3 complex
CRM1-RAN-PHAX-CBC complex (cap binding complex)
CRM1-Survivin mitotic complex
CRM1-Survivin-AuroraB mitotic complex
CRMP-MICAL-PlexinA1 complex, induced by SEMA3A
CRSP complex
CRSP-Mediator 2 complex
CS-MAP3K7IP1-MAP3K7IP2 complex
CSA complex
CSA-POLIIa complex
CSK-GAP-A.p62 complex A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.
CtBP complex
CtBP core complex
CTCF-nucleophosmin complex
CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex
CTF18-cohesion-RFC complex
CTF18-cohesion-RFC-POLH complex
CTF18-CTF8-DCC1 complex
CTF18-CTF8-DCC1-RFC3 complex
CTF18-RFC subcomplex
CTF8-CTF18-DCC1 subcomplex
CTF8-DCC1 subcomplex
CTFC-TAF1 complex
CTGF/Hcs24-actin complex
CTLH complex
CycD1-Cdk4 complex
Cyclin D1-associated protein complex
CyclinA2-Cdk2 complex A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
CyclinB1-Cdc2 complex
CyclinD1-CDK4-CDK6 complex
CyclinD3-CDK4-CDK6 complex
CyclinD3-CDK4-CDK6-p21 complex
Cytochrome bc1-complex (EC 1.10.2.2), mitochondrial
Cytochrome c oxidase (EC 1.9.3.1), mitochondrial
Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n)
DA complex
DAB complex
DAP12 signaling homodimer complex
DAXX-AXIN complex
Daxx-Axin-p53 complex
DAXX-Axin-p53-HIPK2 complex
DAXX-DNMT1-DMAP1 complex
DCP1A-DCP2 Decapping complex
DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF)
DDB complex
DDB2 complex
DDEF1-CTTN-PXN complex
Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
Death-inducing signaling complex DISC (type I cells associated), stimulated
Decapping complex
Delta1 homodimer complex A protein complex that consists of homodimer of the Notch ligand Delta1.
DGCR8 multiprotein complex
DGCR8-ILF3 complex
DGCR8-NCL complex
DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex
DICER1-NCOA6-AGO2 complex
DIPA-MCRS1 complex
DJ-1-SNCA complex, high molecular weight complex
DLP1-hFIS1 complex
DMAP1-associated complex
DNA double-strand break end-joining complex
DNA ligase III-XRCC1 complex A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair.
DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
DNA ligase IV-condensin complex
DNA ligase IV-XRCC1 complex
DNA ligase IV-XRCC4 complex A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.
DNA ligase IV-XRCC4 complex (LX complex)
DNA ligase IV-XRCC4-AHNK complex
DNA ligase IV-Xrcc4-DNA-protein kinase complex
DNA ligase IV-XRCC4-PNK complex
DNA ligase IV-XRCC4-XLF complex
DNA polymerase alpha
DNA polymerase alpha-primase complex
DNA polymerase delta complex
DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
DNA synthesome complex A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
DNA synthesome complex (13 subunits)
DNA synthesome complex (15 subunits)
DNA synthesome complex (17 subunits)
DNA synthesome core complex
DNA-PK-Ku antigen complex A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.
DNA-PK-Ku complex
DNA-PK-Ku-eIF2-NF90-NF45 complex
DNAJB2-HSPA8-PSMA3 complex
DNMT1-G9a complex
DNMT1-G9a-PCNA complex
DNMT1-RB1-HDAC1-E2F1 complex
DNMT3B complex
DNMT3B-DNMT3L complex
DNMT3L-DNMT3A complex
Dok1-Map4k4-Nck1-Rasa1 complex
Dolichol-phosphate mannose (DPM) synthase
DRIP complex
DRIP78-PHLP complex
Drosha complex
DSIF complex (DRB sensitivity-inducing factor complex)
DSS1 complex
Dvl2-Rac complex
Dysbindin-pallidin-muted-beta-dystrobrevin complex
Dysferlin-affixin complex
Dystrophin-sarcoglycan-syntrophin complex, skeletal muscle
E-box sequence-binding complex
E2F-6 complex
E2F1-p107-cyclinA complex
E2F1-Rb complex
E2F4-p107-cyclinA complex
E2F4-p107-cyclinE complex
E2F4-p130 complex
E2F5-RB2-DP1 complex
E2f5-Rbl2-Hdac1 complex
EB1-APC-mDia1 complex
EB1-APC-mDia2 complex
EBAFa complex
EBAFb complex
Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1)
Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1)
Ecsit complex (ECSIT, NDUFS3, NDUFAF1)
Ecsit complex (ECSIT, NDUFS3, TOM20)
Ecsit complex (Ecsit2-Smad1)
Ecsit complex (Ecsit2-Smad4)
Ecsit complex (Smad1-Smad4-Ecsit2)
Ectodermin-SMAD4 complex
EDG1-HTR1D complex
EED-EZH polycomb complex
EED-EZH-YY1 polycomb complex
EED-EZH2 complex
Egasyn-glucuronidase complex
EGFR-CBL-GRB2 complex
EGFR-containing signaling complex
Egfr-Grb2-mSos1 complex, EGF stimulated A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
EGR-EP300 complex
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C)
EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J)
EIF3 complex (EIF3B, EIF3G, EIF3I)
EIF3 complex (EIF3B, EIF3J, EIF3I)
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7)
eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1)
EIF3 core complex (EIF3A, EIF3B, EIF3G, EIF3I)
eIF4AIII-Btz complex
ELK1-SRF-ELK3 complex
ELK1-SRF-ELK4 complex
ELMO1-DOCK1 complex
ELMO1-DOCK1-CRKII complex
ELMO1-DOCK1-RAC1 complex
ELMO1-DOCK2 complex
Elongator core complex A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA, and exerts direct effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.
Elongator holo complex
Emerin architectural complex
Emerin complex 1
Emerin complex 24
Emerin complex 25
Emerin complex 32
Emerin complex 52
Emerin regulatory complex
Emerin-actin-NMI complex
Emerin-actin-NMI-(alphaII)spectrin complex
Endoglin homodimer complex
eNOS-CAV1 complex
eNOS-HSP90 complex, VEGF induced
eNOS-HSP90-AKT complex, VEGF induced
EPO-EPOR complex
Epo-R-IP(3)R type II-TRPC2 complex
Epo-R-PLC-gamma 1-IP(3)R type II-TRPC2 signaling complex
Epo-R-PLC-gamma-TRPC2 complex
EPOR receptor complex
Eps15-stonin2 complex
ER-alpha-c-Jun complex
ER-alpha-GRIP1-c-Jun complex
Er-alpha-p53-hdm2 complex
ERAP1-ERAP2 complex
ERBB2-MEMO-SHC complex
ERCC1-ERCC4-MSH2 complex
ERCC2/CAK complex
ERdj3-BiP complex
eRF1-eRF3-GTP-Mg(2+) complex
ERG-JUN-FOS DNA-protein complex
ESCRT-I complex An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
ESCRT-II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
ESCRT-III complex An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.
ESPL1-CDC2 complex
ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
ESR1-RELA-BCL3-NCOA3 complex
ETS2-ERG complex
ETS2-ETS1 complex
ETS2-FOS-JUN complex
Ets2-Ini1-Smarce1-Smarca4 complex
ETS2-SMARCA4-INI1 complex
Ets2-Smarca4-Smarcb1-Smarce1 complex
EXO1-MLH1-PCNA complex
EXO1-MLH1-PMS2 complex
Exon junction complex
Exon junction complex (EIF4A3-MLN51-MAGOH-Y14)
Exon junction complex (EIF4A3-MLN51-MAGOH-Y14), RNA-protein complex
Exon junction complex (EIF4A3-MLN51-UPF3B-MAGOH-Y14)
Exon junction complex (F4A3-MLN51-UPF3B-MAGOH-Y14-PYM)
Exon junction complex (mRNA splicing-dependent)
Exon junction complex, EIF4A3-MLN51-MAGOH-Y14 (RNA-protein complex)
Exosome
Eya1/3-Dach1/2-Six1 complex
F1F0-ATP synthase (EC 3.6.3.14), mitochondrial
FA complex (Fanconi anemia complex)
FA complex (Fanconi anemia complex), cytoplasmic
FA core complex (Fanconi anemia core complex)
FA core complex 1 (Fanconi anemia core complex 1)
FACT complex An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.
FACT complex, UV-activated
FACT-NEK9 complex
FAK-beta5 integrin complex, VEGF induced
Farnesyltransferase
FARP2-NRP1-PlexinA1 complex
FARP2-NRP1-PlexinA2 complex
FARP2-NRP1-PlexinA3 complex
FARP2-NRP1-PlexinA4 complex
FAS-FADD-CASP10 complex
FAS-FADD-CASP8 complex
FAS-FADD-CASP8-CASP10 complex
FCP1-associated protein complex
FE65-TSHZ3-HDAC1 complex
FEN1-9-1-1 complex
Fertilin complex (Adam1a, Adam2)
Fertilin complex (Adam1b, Adam2)
Fgf2-Ck2 complex
Fgf2-Rsk2 complex
FGFR2-c-Cbl-Lyn-Fyn complex
Fgr-Pyk2-p190RhoGap complex
FHL2 homodimer complex
FHL2-ACT complex
FHL2-CREB complex A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.
FHL2-FHL3 complex
FHL2-p53-HIPK2 complex
FHL3 homodimer complex
FHL3-CREB complex A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.
FHL4/STX11-ACT complex
FIB-associated protein complex
FIF-FGR2 complex
FKBP12-FK506 complex
Fmrp-Lgl complex
FN1-TGM2 complex
Foxh1-Nkx2-5 complex
FOXO1-FHL2-SIRT1 complex
FOXO3-PCAF complex, oxidative stress stimulated
FOXO3-SIRT1 complex, oxidative stress stimulated
FOXO3-TP53 complex, oxidative stress stimulated
Foxo4-Srf-Myocd complex
Frs2-Grb2-Shp2 complex, FGF stimulated
Frs2-Shp2 complex, FGF stimulated
FYB-CARMA1-BCL-10-MALT1 complex
G protein complex (BTK, GNG1, GNG2) A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
G protein complex (Btk, Gng2, Gnb1) A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.
G protein complex (CACNA1A, GNB1, GNG2)
G protein complex (GNG2, GNB2L1, RAF1) A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.
G protein complex (Gngt2, Kcnj3, Gnb1)
G protein complex (Gngt2, Kcnj6, Gnb1)
G protein complex (HDAC4, GNB1, GNG2)
G protein complex (HDAC5, GNB1, GNG2)
G protein complex (MCF2, GNB1, GNG2)
G protein complex (PTHR1, GNB1, GNG2)
GAA1-GPI8-PIGT-PIG-PIGS complex
GABAA receptor
GABBR2-HTR1A complex
GABP(gamma)1-E2F1-DP1 complex
GAIT complex A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
GALNS-lysosomal hydrolase 1.27 MDa complex A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.
Gamma-BAR-AP1 complex
Gamma-secretase complex (Aph1a, Ncstn, Psen1, Psenen, Tmp21)
Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN)
Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.
Gamma-secretase-Delta1 complex A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
GammaH2AFX-NDHII-Ku70-DNA complex
Gata1-Fog1 complex
Gata1-Fog1-MeCP1 complex
Gata1-Gfi1b complex
Gata1-Ldb1-Tal1 complex
Gata1-Snf2h complex
Gata1-Tal1-Tcf3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
Gata2-Tal1-Tcf3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.
GCN5-TRRAP histone acetyltransferase complex
GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
GIPC1-LHCGR complex
GIPC1-NTRK1-RGS19 complex
Girdin homo-oligomer complex
GLE1-NUPL2-NUP155 complex
GluR delta-2 complex, postsynaptic (GluR delta-2, Shank1, Shank2, mGluR1 alpha, Homer, PSD-95)
GluR6a-GluR6b-KA2 complex
GNA14-p115RhoGEF complex
GNAQ-GEFT-RHOA complex
gp78-p97/VCP-DERL1 complex
GPI-GnT activity complex
GPR56-CD81-Galphaq/11-Gbeta complex
GR-hnRNP U complex
Grancalcin-sorcin complex
GRASP-GRP1 complex
Grb2-Lab-Blnk complex, BCR stimulated
Grb2-mSos1 complex A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
GRB2-SHP-2 complex, PDGF stimulated A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.
Grb2-Shp2 complex, FGF stimulated
Grb2-Sos complex, Fc receptor gamma-R1 stimulated
Grin2a-Lrp8 complex
Grin2b-Lrp8 complex
GTP-Rho-Rhpn1-Ropn1 complex
Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3)
H2AX complex I
H2AX complex II
H2AX complex, isolated from cells without IR exposure
hASC-1 complex
HBO1 complex
HCF-1 complex
HD-RAB8A-OPTN complex
HDAC1-associated core complex cI
HDAC1-associated core complex cII
HDAC1-associated protein complex
Hdac1-Mecp2-Rcor1-Sin3a complex
HDAC2-asscociated core complex
HDAC4-ERK1 complex
HDAC4-ERK2 complex
HERP1/HEY2-NCOR-SIN3A complex
HES1 promoter corepressor complex
HES1 promoter-Notch enhancer complex
HESX1-TLE1 complex
Heterodimer complex (CDK9, IL6ST)
Heterotrimeric complex (CCNT1, CDK9, GRN)
Heterotrimeric G protein complex (GNG2, GNB1, GNAS)
Heterotrimeric SKP1-CUL1-ROC1 complex
HGF-Met complex
HIF1A-OS9-EGLN1 complex
HIF1A-OS9-EGLN3 complex
Hip1R-cortactin complex
Histone H3.1 complex
Histone H3.3 complex
hMediator complex (MED23, CDK8, CCNC)
hMediator complex (MED23, CDK8, CCNC, MED7)
HMGB1-HMGB2-HSC70-ERP60-GAPDH complex
Hnf4-Pc4 complex
HNF4A-SUB1 complex
HNRPF-HNRPH1 complex
hNURF complex
Homodimeric complex LTBR
Homotetrameric complex NIAP
Hop2-Mnd1 complex
HPFH(-198) complex
hPRC1L complex
hRAD51C-hXRCC3 complex
hs4 enhancer complex (faster migrating complex)
hs4 enhancer complex (slow migrating complex)
HSF1-HSF2 complex
HSF1-YWHAE complex
hSIR2-p53 complex
Hsp110-Hsc70-Hsp25 complex
HSP70-BAG5-PARK2 complex
HSP90-CDC37-LRRK2 complex
HSP90-CIP1-FKBPL complex
HSP90-FKBP38-CAM-Ca(2+) complex
HTR1A homodimer complex
HTR1A-EDG1 complex
HTR1A-EDG3 complex
HTR1A-GPR26 complex
HTR1A-HTR1B complex
HTR1A-HTR1D complex
HTR1B homodimer complex
HTR1D homodimer complex
HTR1D-HTR1B complex
Htt-Dctn1-Hap1 complex
HuCHRAC complex
HUIC complex
I(kappa)B(alpha)-NF(kappa)Bp50-NF(kappa)Bp65 complex
I-kappa-B kinase (IKK) complex
IFNB1-IFNAR1-IFNAR2- complex
IFP35-NMI complex
IGF1-IGFBP3-ALS complex
IGHM-VPREB1-IGLL1 complex
IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14)
Ikaros complex
Ikaros-NuRD complex
IKB(alpha)-RELA-cREL complex
IKB(beta)-RELA-cREL complex
IKB(epsilon)-RELA-cREL complex
IKBA-NF(kappa)Bp65-NF(kappa)Bp50 complex
IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex
IKBKG homodimer complex
IKBKG homotrimer complex
IKBKG tetramer complex
IKBKG-CHUK complex
IKBKG-IKBKB complex
IKK-alpha--ER-alpha-AIB1 complex
IKKA-IKKB complex
IKKB-NIK complex
IL-12 heterodimer complex
IL-12 subunit p40 homodimer complex
IL12A homodimer complex
IL12A-IL12B complex
IL12A-IL12B-IL12RB1 complex
IL12A-IL12B-IL12RB2 complex
IL12B-IL12RB1-IL12RB2 complex
IL12RB1-IL12RB2 complex
IL2-IL2RA-IL2RB complex
Il3rb1-Shc complex, IL-3 stimulated
Il3rb1-Shc-Ship complex, IL-3 stimulated
IL4-IL4R complex
IL4-IL4R-IL2RG complex
IL6ST-PRKCD-STAT3 complex
ILF3-XPO5 complex
ILK-PARVB-ARHGEF6 complex
immunoproteasome
IMP3-IMP4-MPP10 complex
ING1-p300-PCNA complex
ING1-PCNA complex
ING2 complex
ING4 complex (ING4, MYST2, C1orf149, PHF15)
ING4 complex (ING4, MYST2, C1orf149, PHF16)
ING4 complex (ING4, MYST2, C1orf149, PHF17)
ING5 complex
INO80 chromatin remodeling complex A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.
InsP3R1-HAP1A-Htt complex
Integrator complex A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
Integrator-RNAPII complex
Interferon-stimulated gene factor 3 transcription complex ISGF3
IPO13-RAN-EIF1AX complex
IPO13-RBM8A-MAGOH complex
IRAK1-IRAK2 complex
IRAK1-IRAK3 complex
IRF3-CBP complex
Isl1-Jak1-Stat3 complex
Isocitrate dehydrogenase, cytoplasmic
ITAGV-ITGB3-F11R complex
ITCH-FAM/USP9x complex
Itga-Itgb1-Ppap2b complex
ITGA1-ITGB1-COL6A3 complex A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
ITGA1-ITGB1-PTPN2 complex A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2.
ITGA10-ITGB1 complex
ITGA11-ITGB1 complex
ITGA11-ITGB1-COL1A1 complex A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen.
ITGA2-ITGB1 complex
ITGA2-ITGB1-CD47 complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47.
ITGA2-ITGB1-CHAD complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.
ITGA2-ITGB1-COL6A3 complex A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.
ITGA2B-ITGB3 complex
ITGA2b-ITGB3-CD47-FAK complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.
ITGA2b-ITGB3-CD47-SRC complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.
ITGA2b-ITGB3-CD9 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9.
ITGA2b-ITGB3-CD9-GP1b-CD47 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib.
ITGA2B-ITGB3-CIB1 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.
ITGA2B-ITGB3-F11R complex
ITGA2B-ITGB3-FN1-TGM2 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase.
ITGA2B-ITGB3-ICAM4 complex
ITGA2b-ITGB3-TLN1 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin.
ITGA3-ITGB1 complex
ITGA3-ITGB1-BSG complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin.
ITGA3-ITGB1-CD151 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151.
ITGA3-ITGB1-CD63 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63.
ITGA3-ITGB1-THBS1 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin.
ITGA4-ITGB1 complex
Itga4-Itgb1-Adam2 complex
ITGA4-ITGB1-CD47 complex
ITGA4-ITGB1-CD53 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.
ITGA4-ITGB1-CD63 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.
ITGA4-ITGB1-CD81 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.
ITGA4-ITGB1-EMILIN1 complex
ITGA4-ITGB1-JAM2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2.
ITGA4-ITGB1-THBS1 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1.
ITGA4-ITGB1-THBS2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.
ITGA4-ITGB1-VCAM1 complex
ITGA4-PXN-GIT1 complex
ITGA5-ITGB1-ADAM15 complex
ITGA5-ITGB1-CAL4A3 complex A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen.
ITGA5-ITGB1-FN-1-NOV complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV.
ITGA5-ITGB1-FN1-TGM2 complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase.
ITGA5-ITGB1-SPP1 complex A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin.
ITGA5-ITGB3-COL6A3 complex
ITGA5-ITGB4 complex
ITGA6-ITGB1 complex
ITGA6-ITGB1-CD151 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151.
ITGA6-ITGB1-CYR61 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis.
ITGA6-ITGB4 complex
ITGA6-ITGB4-CD151 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151.
ITGA6-ITGB4-CD9 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9.
ITGA6-ITGB4-FYN complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn.
ITGA6-ITGB4-LAMA5 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5.
ITGA6-ITGB4-Laminin10/12 complex
ITGA6-ITGB4-SHC1-GRB2 complex
ITGA7-ITGB1-CD151 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151.
ITGA7-ITGB1-CD9 complex
ITGA7-ITGB1-ITGB1BP3 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP).
ITGA8-ITGB1 complex
ITGA9-ITGB1-ADAM12 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12.
ITGA9-ITGB1-ADAM15 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15.
ITGA9-ITGB1-ADAM8 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8.
ITGA9-ITGB1-ADAM9 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9.
ITGA9-ITGB1-FIGF complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D.
ITGA9-ITGB1-SPP1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.
Itga9-Itgb1-Thbs1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1.
ITGA9-ITGB1-TNC complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin.
ITGA9-ITGB1-VCAM1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1.
ITGA9-ITGB1-VEGFA complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A.
ITGA9-ITGB1-VEGFC complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C.
ITGAE-ITGB7-CDH1 complex A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin.
ITGAM-ITGB2-CD11 complex
ITGAV-ITGB1 complex
ITGAV-ITGB1-SPP1 complex A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin.
ITGAV-ITGB3 complex
ITGAV-ITGB3-ADAM15 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15.
ITGAV-ITGB3-ADAM23 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23.
ITGAV-ITGB3-CD47-FCER2 complex
ITGAV-ITGB3-COL4A3 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen.
ITGAV-ITGB3-EGFR complex A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor.
Itgav-Itgb3-Gsn complex A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin.
ITGAV-ITGB3-LAMA4 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4.
ITGAV-ITGB3-NOV complex
ITGAV-ITGB3-PPAP2b complex A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3.
ITGAV-ITGB3-PXN-PTK2b complex A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2.
ITGAV-ITGB3-SLC3A2 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98.
ITGAV-ITGB3-SPP1 complex A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin.
ITGAV-ITGB3-THBS1 complex A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin.
ITGAV-ITGB5 complex
ITGAV-ITGB5-ADAM9 complex
ITGAV-ITGB5-CYR61 complex
ITGAV-ITGB5-ICAM4 complex
ITGAV-ITGB5-PLAUR complex
ITGAV-ITGB5-SPP1 complex A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin.
ITGAV-ITGB6 complex
ITGAV-ITGB6-SPP1 complex A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin.
ITGAV-ITGB6-TGFB3 complex
ITGAV-ITGB8-MMP14-TGFB1 complex A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1).
ITGAV-P2RY2-GNA12 complex
Itgax-Itgb2-Icam4 complex A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4.
ITGB1-ITGA9 complex
ITGB1-NRP1 complex
ITGB1-RAP1A-PKD1 complex
Itgb1-Rap1a-Prkd1 complex
ITGB3-ITGAV-CD47 complex A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).
ITGB3-ITGAV-VTN complex
ITGB5-ITGAV-VTN complex
ITGB6-FYN-FN1 complex
ITK-SLP-76 complex, anti-TCR stimulated
JAK2-IL12RB2 complex
JBP1-pICln complex
JUN-TCF4-CTNNB1 complex
Junb-Sumo1 complex
JUND-FOSB-SMAD3-SMAD4 complex
Kaiso-NCOR complex
KCNQ1 macromolecular complex
Keap1-Nrf2-Cul3 complex
Kif13a-AP1 complex
Kif17-Lin10 complex
Kif17-Lin10-Lin2-Lin7-NR2B complex
Kif3-cadherin-catenin complex
KIN17-PCNA-RPA70 complex
Kinase maturation complex 1
Kinase maturation complex 2
Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN
Kir3.2 homotetramer complex
Kir4.1-alpha-1-syntrophin complex, cortical astrocytes
Kir4.1-alpha-1-syntrophin complex, whole brain lysate
Kir4.1-beta-dystroglycan complex, cortical astrocytes
Kir4.1-beta-dystroglycan complex, whole brain lysate
Kir4.1-dystrophin complex, cortical astrocytes
Kir4.1-dystrophin complex, whole brain lysate
Kir6.2-Sur1 complex
KLC1-nKHC-uKHC kinesin complex
KLC2-nKHC-uKHC kinesin complex
Klf5-Pias1 complex
Kpna2-Kpnb1 complex
Ksr1 complex (Ksr1, Mek, 14-3-3), unstimulated
Ksr1 complex (Ksr1, Mek, 14-3-3, Mapk), EGF stimulated
KSR1 homooligomer complex
KSR1-BRAF-MEK complex
Ksr1-CK2 complex
Ksr1-CK2-MEK-14-3-3 complex, PDGF treated
Ksr1-Mek-Braf complex, EGF induced
Ksr1-Mek-Braf-Erk complex, EGF induced
Ksr1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
Ksr1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
KSR1-RAF1-MEK complex
Ku antigen complex
Ku antigen-NARG1 complex
Ku antigen-YY1-alphaMyHC promoter complex
Ku-ORC complex
Ku70/Ku86 complex
Ku70/Ku86/Werner complex
Kv4.2-DPP10 channel complex
L-periaxin-Drp2 complex
Lab-Grb2 complex, BCR stimulated
LARC complex (LCR-associated remodeling complex)
Large Drosha complex
LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated
LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated
LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated
LAT2-ITGB1 complex
LATS1-HTRA2-BIRC4 complex
LCK-SLP76-PLC-gamma-1-LAT complex, pervanadate-activated
Ldb1-Lmo2-Gata-1-Tal1-E47 complex
Lef1-Tle1 complex
Lef1-Tle1-Ctnnb1 complex
LEPR homodimer complex
LIFR-LIF-gp130 complex
LIG1-9-1-1 complex
Limd1-p62-Traf6-Prkcz complex
LIN2-LIN7 complex
LIN2-LIN7-SAP97-MINT1 complex
LIN9-BMYB complex
LINC complex, quiescent cells
LINC complex, S-phase
LINC core complex
LINGO-1-Nogo-66-p75 signaling complex
Lingo1-Rtn4r-Tnfrsf19 complex
LLGL1-PAR-6B-PRKCI complex
LLGL2-PAR-6B-PRKCI complex
LMO4-BRCA1-CTIP-LDB1 complex
LMO4-CREB complex
LMO4-gp130 complex
Lnx1-Jam4 complex
LRP-1-Alpha-2-M-annexin VI complex
LSD1 complex
LSD1-CoREST complex
LSm1-7 complex
LSm2-8 complex
Lymphotoxin beta receptor complex
MAD-MAX complex A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.
Mad-Max-mSin3a complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.
Mad-Max-mSin3B complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.
MAD1-mSin3A-HDAC2 complex
MAD1L1 homodimer complex
MAD1L1-MAD2L1 complex
MAD2-CDC20 complex
MAF1 complex
MAF2 complex
MALT1 oligomer complex
MAML1-RBP-Jkappa-Notch1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
MAML2-RBP-Jkappa-Notch3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
MAML3-RBP-Jkappa-Notch3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.
MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex
Map2k5-Map3k3 complex
MAP2K5-PRKCI-SQSTM1 complex
MASH1 promoter-coactivator complex
MBD1-MCAF complex
MBD1-MCAF1-SETDB1 complex
MBD1-Suv39h1-HP1 complex
MCL1-BAK1 complex
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.
MCM2-MCM4-MCM6-MCM7 complex
MCM2-MCM6-MCM7 complex
MCM4-MCM6-MCM7 complex
MCM8-ORC2-CDC6 complex
MDC1-H2AFX-TP53BP1 complex
MDC1-MRE11-RAD50-NBS1 complex
MDC1-MRN-ATM-FANCD2 complex
MDC1-p53BP1-SMC1 complex
Mdm2-P53 complex
MeCP1 complex
MeCP2-SIN3A-HDAC complex
MED18-MED20-MED29 mediator subcomplex
Mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Mediator complex 1
Mediator complex 2
Meiotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
Mekk1-Axin complex
Membrane protein complex (DERL1, SELS, VCP)
Membrane protein complex (VCP, UFD1L, SEC61B)
Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
Menin-associated histone methyltransferase complex
Meprin A
MET-CIN85-SH3GL3-CBL complex, HGF stimulated
Metallothionein-3 complex
Metaxin complex
MGC1-DNA-PKcs-Ku complex
Mi-2/NuRD-MTA2 complex
Mi2/NuRD complex
Mi2/NuRD-BCL6-MTA3 complex
MICA-KLRK1-HCST complex
MICB-KLRK1-HCST complex
Microprocessor complex A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
MIRO2-Milton complex
Mis12 centromere complex
Mitotic 14S cohesin 1 complex
Mitotic 14S cohesin 2 complex
Mitotic checkpoint complex (MCC)
MKK4-ARRB2-ASK1 complex
MKK4-ARRB2-JNK3 complex
MKP3-CK2alpha complex
MLL-HCF complex
MLL1-WDR5 complex
Mlx-Mad1 complex
MMP-2-claudin-1 complex
MMP-9-TIMP-1-LRP complex
MNK1-eIF4F complex
MOF complex
Molybdopterin synthase
MondoA-Mlx complex
mPar6c-Mlgl-aPKC complex
mPar6c-Mlgl-aPKCz complex
MPP4-MPP5-CRB1 complex
MR-UBC9-SRC1 complex
MRE11A-RAD50-NBN-TRF2 complex
MRG15-PAM14-RB complex
MRIP-MBS complex
MRIP-MBS-RHOA complex
MRIP-RHOA complex
MRIT complex
MRN complex (MRE11-RAD50-NBN complex)
MRN complex (MRE11-RAD50-NBS1 complex)
MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex)
mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)
MSH2-MLH1-PMS2 DNA-repair initiation complex
MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex
MSH2-MSH3 complex
MSH2-MSH6 complex
MSH2-MSH6-PMS1-MLH1 complex
MSH2-MSH6-PMS2-MLH1 complex
MSH2/6-BLM-p53-RAD51 complex
MSH4-MSH5-GPS2 complex
mSin3A complex
mSin3A-HDAC1-HDAC2 complex
MSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
Mss4-Itga3 complex
Mss4-Itga7 complex
MT1-MMP-claudin-1 complex
Mt3-Hsp84-Ck complex
MTA1 complex
MTA1-HDAC core complex
MTA2 complex
MTNR1A homodimer complex
MTNR1A-MTNR1B complex
MTNR1B homodimer complex
mTOR-RAPTOR complex
mTOR-RICTOR complex
mTOR-signaling complex
mTOR-signaling complex (FRAP1/mTOR, GBL, RAPTOR)
mTOR-signaling complex (mTOR/FRAP1, RAPTOR)
mTORC1 complex (mTOR/FRAP1, LST8, RAPTOR)
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR)
mTORC2 complex (mTOR/FRAP1, LST8, mAVO3/RICTOR, SIN1)
Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n)
Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n)
Multiprotein complex (monoubiquitination)
Multiprotein complex (mRNA turnover)
Multisubunit ACTR coactivator complex
Multisynthetase complex A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
MURR1-NF(kappa)Bp65-IKBA complex
MUS81-CDS1 complex
Muscle-derived dystrobrevin-syntrophin complex
MutL-alpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
MutL-beta complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.
MutS-alpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
MutS-alpha-histone H4 complex
MutS-alpha-PK-zeta complex
MutS-beta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.
MYC-DNMT3A-ZBTB17 complex
MYC-MAX complex A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max.
MYC-MAX-BLOC1S1 complex
Myod1 homodimer complex
Myod1-Tcf3 complex
MYOM1 homodimer complex
N-NOS-CHIP-HSP70-1 complex
N-WASp homomer
NAT complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.
NCBP-NIP1 complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
NCOA6-DNA-PK-Ku-PARP1 complex
NCOR complex
NCOR-HDAC3 complex
NCOR-SIN3-HDAC-HESX1 complex
NCOR-SIN3-HDAC1 complex
NCOR-SIN3-RPD3 complex
NCOR1 complex
NCOR2 complex
NCR3-CD247 complex
NDC80 kinetochore complex
NDPKA-AMPKalpha1 complex
Neddylin ligase (FBXO11, SKP1, CUL1, RBX1)
NEK2-NEK11 complex
NELF complex (Negative elongation factor complex)
NEMO-HIF2(alpha)-ARNT complex
Neurotrophin-3-p75 complex
NFAT-JUN-FOS DNA-protein complex
Nfatc2ip-Prmt1
NFKB1-NFKB2-REL-RELA-RELB complex
NFKB1-NFKB2-RELA-RELB complex
Nfkb1-Rela complex
Ng2-Grip1-Glur2 complex
NGF-p75 complex
NGF-TrkA complex
NgR-TROY-LINGO1 complex
Nitric oxide synthase-dystrophin complex, skeletal muscle A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase.
NK-3-Groucho complex
NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex
nKHC-KLC1-KLC2 kinesin complex
NMI homodimer complex
NMI-POLR1B-RRN3 complex
Nmi-Rpa2-Rrn3 complex
Nmi-Rrn3 complex
nNos-Capon-Dexras1 complex
NOD1 homodimer complex
Nogo-potassium channel complex
Nop56p-associated pre-rRNA complex
NOS3-CAV1-NOSTRIN complex
Notch1(N-TM)-Notch1(N-EC) heterodimer complex
Notch1-fraction 30 complex
Notch1-p56lck-PI3K complex
Notch2(N-TM)-Notch2(N-EC)-Delta complex
NPC subcomplex (NUP98, NUP107, NUP133, NUP160)
NR3C2-UBC9-SRC-1 complex
NRD complex (Nucleosome remodeling and deacetylation complex)
NRG1-IKZF4 complex
Nrp1-PlexinD1 complex
NRP1-VEGF(165/121) complex
NRP1-VEGFC complex, heparin dependent
NRP1-VEGFD complex, heparin dependent
NRP1-VEGFR2-VEGF(165) complex
NRP2-VEGFC complex
NRP2-VEGFD complex, heparin dependent
NRP2-VEGFR3 complex
NTF4 homodimer complex
NuA4/Tip60 HAT complex
NuA4/Tip60-HAT complex A
NuA4/Tip60-HAT complex B
Nucleic and chromatin Fanconi complex
Nucleolar remodeling complex (NoRC complex)
NuMA-LGN-G-alpha-i-1 complex
NUMAC complex (nucleosomal methylation activator complex)
NUMB-TP53-MDM2 complex
Nup 107-160 subcomplex
NuRD.1 complex
OAP-1-OSP/claudin-11-ITGB1 complex
Ocrl-Cdc42 complex
OCT1-OBF1-DNA complex
OCT1-OBF1-DNA-TLE1 complex
OCT1-SOX2 DNA-protein complex
OCT2-TLE4 complex
OCT4-SOX2 DNA-protein complex
OGT-TRAK1-TRAK2 complex
Olfr992-Reep1 complex
Olfr992-Rtp1 complex
Oligosaccharyltransferase complex (Stt3A variant)
Oligosaccharyltransferase complex (Stt3B variant)
ORC 1-5 complex (origin recognition 1-5 complex)
ORC 2-4 complex (origin recognition 2-4 complex)
ORC 2-5 complex (origin recognition 2-5 complex)
ORC complex (origin recognition complex)
ORC5-ORC1 complex
P-TEFb-7SKRNA-HEXIM1 complex
P-TEFb-BRD4-TRAP220 complex
P-TEFb-SKP2 complex
P-TEFb.1 complex
P-TEFb.2 complex
P-TEFb.4 complex
p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex
p14-Mp1-Erk1/2 complex
p14-Mp1-ERK2 complex
p14-Mp1-MEK1 complex
p16-cyclin D2-CDK4 complex
p18-Cdk4 complex
p18-Cdk6 complex
p19-Cdk4 complex
p19-Cdk4-cyclinD2 complex
p19-Cdk6 complex
p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.
p23 protein complex
p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex
p27-cyclinE-CDK2 complex
P2X7 receptor signalling complex
p300-CBP-p270 complex
p300-CBP-p270-SWI/SNF complex
p300-MDM2-p53 protein complex
p300/CBP-PCAF-MyoD complex
p32-CBF-DNA complex
p33ING1b-HDAC1 complex
p33ING1b-p300 complex
p33ING1b-PCNA complex
p34(SEI-1)-CDK4-CyclinD2 complex
p400-associated complex
p50-p65 NF(kappa)B complex
p50-p65 NF(kappa)B-SRC1 complex
p53 homotetramer complex
P53-BARD1-Ku70 complex
p53-Bcl-xL complex, DNA-damage induced
p53-SP1 complex
p54(nrb)-PSF-matrin3 complex
p56(LCK)-CAML complex
p97-Ufd1-Npl4-IP3 receptor complex
p97/VCP homohexamer complex
p97/VCP-VIMP-DERL1 complex
p97/VCP-VIMP-DERL1-DERL2-HRD1-SEL1L complex
p97/VCP-VIMP-DERL2 complex
PA28 complex
PA28-20S proteasome
PA28gamma complex
PA28gamma-20S proteasome
PA700 complex
PA700-20S-PA28 complex
PABPC1-HSPA8-HNRPD-EIF4G1 complex
PAC1-PAC2 complex
PAC3-PAC4 complex
Paf complex
Pallidin-Mu complex
Par-3-p75NTR complex
PAR-3-PAR-6B-PRKCI complex
PAR-3-VE-cadherin complex, endothelial
PAR-3-VE-cadherin-beta-catenin complex
PAR-6-PAR-3-VE-cadherin complex, endothelial
PAR-6-VE-cadherin complex, endothelial
PAR3-PAR6-PALS1 complex
PAR4-BACE1 complex
PAR6-CDC42 complex
PARVB-ARHGEF6 complex
Parvulin-associated pre-rRNP complex
Pax3-Lef1-Tle4 complex
PAX6-SOX2 DNA-protein complex
Pax7-HMT complex
PAX9-MSX1 complex
PBAF complex (Polybromo- and BAF containing complex)
PC2 complex
PCAF complex A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.
Pcdha7-Pcdhga1 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
Pcdha7-Pcdhga3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
Pcdha7-Pcdhgb2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
Pcdha7-Pcdhgb4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
Pcdhga1-Pcdha4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane.
Pcdhga1-Pcdhga3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane.
Pcdhga1-Pcdhgb2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane.
Pcdhga1-Pcdhgb4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.
PCI-PSA-SCG2 complex
PCNA homotrimer complex
PCNA-CHL12-RFC2-5 complex
PCNA-DNA ligase complex
PCNA-DNA polymerase delta complex
PCNA-KU antigen complex
PCNA-MLH1-PMS1 complex
PCNA-MSH2-MSH6 complex
PCNA-MutS-alpha-DNA initial complex
PCNA-MutS-alpha-MutL-alpha-DNA complex
PCNA-p21 complex A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
PCNA-PAF complex
PCNA-RFC2-5 complex
PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
PDGFRA-SHP-2 complex, PDGF stimulated A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.
PDZK1-NaPiIIa-MAP17 complex
Pericentrin-GCP complex
PEX14 homodimer complex
Pex26-Pex6-Pex1 complex
PGAM5-KEAP1-NRF2 complex
PGC-1-SRp40-SRp55-SRp75 complex
PGRMC1-SCAP complex
PHAX-CBC complex (cap binding complex)
Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1)
Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)
PIAS3-SMAD3-P300 complex
PICK1-GRIP1-GLUR2 complex
PID complex
PIDDsome complex
Pik3r5-Pik3cg complex
PIN1-AUF1 complex
PINK1-MIRO2-Milton complex
PIP complex
PKC-alpha-PLD1-PLC-gamma-2 signaling complex, lacritin stimulated
PKD2-FPC complex
Pkd2-Fpc-Kif3b complex
PKD2-PACS1 complex
Pkhd1-Pkd2 complex
PLC-gamma-1-Lab-Blnk complex, BCR stimulated
PLC-gamma-1-LAT-c-CBL complex, OKT3 stimulated
PLC-gamma-1-SLP-76-SOS1-LAT complex
PLC-gamma-2-Lab-Blnk complex, BCR stimulated
PLC-gamma-2-LAT complex
PLC-gamma-2-Lyn-FcR-gamma complex
PLC-gamma-2-SLP-76 complex
PLC-gamma-2-SLP-76-Lyn-Grb2 complex
PLC-gamma-2-Syk-LAT-FcR-gamma complex
PLCB1-PARD3-PARD6A complex
PLCB3-PARD3-PARD6A complex
PLEKHM2-KIF5B complex
PlexinA1-NRP1 complex
PlexinA1-NRP1-SEMA3A complex
PlexinA1-PlexinB1 complex
PLXNA1-RANBPM complex
PLXNA2-RANBPM complex
PLXNA3-RANBPM complex
PLXNA4-RANBPM complex
PML-SMAD2/3-SARA complex
PNUTS-PP1 complex
POLR1B-RRN3 complex
POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex
Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)
Polycomb repressive complex
Polycomb repressive complex 1 (PRC1, hPRC-H)
Polycomb repressive complex 2 (PRC 2)
Polycomb repressive complex 2 (PRC2)
Polycomb repressive complex 3 (PRC3)
Polycomb repressive complex 4 (PRC4)
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)
Polycystin-1-E-cadherin-beta-catenin complex
Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex
POSH-AKT2 complex
POSH-MLK3 complex
Postsplicing complex
PPD complex
PPP2CA-PPP2R1A complex
PPP2CA-PPP2R1A-PPP2R3A complex
PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex
PPP3CA-PPP3CA-RCAN1 complex
PPP4C-PPP4R2-Gemin3-Gemin4 complex
pRB-E2F-1 complex
pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2)
pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2)
pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300)
pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300)
Pre-initiation complex (PIC)
Prefoldin
Prefoldin complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
PRKAC-AKAP5-ADRB1 complex
PRL receptor (PRLR) dimer complex
PRMT1 complex
PRMT2 homo-oligomer complex
PRMT2 homodimer complex
PRMT5 complex
PRNP homo-oligomer complex
Prnp homodimer complex
PRNP-ApolopoproteinE3 complex
Profilin 1 complex
Profilin 2 complex
Prolactin (PRL) - PRL receptor (PRLR) complex
Prolyl 4-hydroxylase (alpha(I)-type)
Prolyl 4-hydroxylase (alpha(III)-type)
Protein kinase A II alpha homodimer complex
Protein phosphatase 4 complex The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit.
Protein-sorting complex (Stam2, Hgs, Eps15)
Prune-Gelsolin complex
Prune-GSK3beta complex
Prune/Nm23-H1 complex
PS1-E-cadherin-catenin complex, brain
Psd3-Actn1 complex
PSD95-FYN-NR2A complex
PSF-p54(nrb) complex
PTF1 complex (Ptf1a, Tcf12, Rbpj)
PTF1-bHLH complex
PTGS2 homodimer complex
PTIP-DNA damage response complex
PTIP-HMT complex
PTPRA homodimer complex
PU.1-associated protein complex
PU.1-SIN3A-HDAC complex
PU.1-Sin3A-Hdac-MeCP2 complex
PU.1-TBP complex
PUMA-Bcl-xL complex, DNA-damage induced
PXN-ITGB5-PTK2 complex
PYR complex
Quaternary complex (Dvl, Gsk3b, Frat1, Axin1)
R/M complex (RAD50-MRE11 complex)
Rab11Fip2-Ap2a complex
Rab27a-melanophilin-myosin-Va complex
Rab27A-Melanophilin-MyosinVa complex
Rab27a-Mlph-Myo5a complex
Rab3a-Rims2-Rapgef4 complex
Rab5 GDP/GTP exchange factor complex
RAB5-EEA1 complex
RAB9-TIP47-MPRI complex
RAD17-RFC complex
RAD17-RFC-9-1-1 checkpoint supercomplex
RAD50-BRCA1 complex
RAD50-MRE11-NBN-p200-p350 complex
RAD51-DMC1 complex
RAD51B-RAD51C complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.
RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex
RAD51C-XRCC3 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.
RAD51L3-XRCC2 complex
RAD52-ERCC4-ERCC1 complex A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.
RAD9-RAD1-HUS1-APE1 complex
RAD9-RAD1-HUS1-POLB complex
RAF1-BRAF complex, RAS stimulated
RAF1-CNK1 complex, RAS stimulated
RAF1-MAP2K1-YWHAE complex
Raf1-PP2A core enzyme complex (Ppp2r1a, Ppp2ca), untreated
Raf1-PP2A holoenzyme complex (Ppp2r1a, Ppp2r2b, Ppp2ca), PDGF stimulated
RAF1-PPP2-PIN1 complex
RAF1-RAS complex, EGF induced
Rag1-Rag2 protein-DNA complex
RAG1-RAG2 tetramer complex
Rag1-Rag2-Ku70-Ku80 protein-DNA complex
RalBP1-CCNB1-AP2A-NUMB-EPN1 complex
RalBP1-CDC2-CCNB1 complex
RANBMP-CD39 complex
RANBP1-RAN-KPNB1 complex
RANBPM-Muskelin-TWA1-HSMpp8 complex
RANBPM-SMP1 complex
Rap1 complex
RAPTOR-mTOR complex
RasGAP-AURKA/AURKB-survivin complex
Rb-HDAC1 complex
Rb-NeuroD1-Ngfi-B complex
Rb-tal-1-E2A-Lmo2-Ldb1 complex
RB1(hypophosphorylated)-E2F4 complex
RB1-HDAC1-BRG1 complex
Rb1-Runx2 complex
RB1-TFAP2A complex
RBP-Jkappa-Notch1 complex
RBP-Jkappa-RING1-KyoT2 complex
RBP-Jkappa-SHARP complex
RBPJ-NotchIC-Mastermind complex
RC complex (Replication competent complex)
RC complex during G2/M-phase of cell cycle
RC complex during S-phase of cell cycle
RCP-Rab11 complex
REL-MAP3K8-RELA-TNIP2-PAPOLA complex
Remodeling and spacing factor (RSF) complex
Replication-coupled CAF-1-MBD1-ETDB1 complex
Respiratory chain complex I (beta subunit) mitochondrial
Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial
Respiratory chain complex I (gamma subunit) mitochondrial
Respiratory chain complex I (holoenzyme), mitochondrial
Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial
Respiratory chain complex I (incomplete intermediate), mitochondrial
Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial
Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial
Respiratory chain complex I (intermediate II/230kD), mitochondrial
Respiratory chain complex I (intermediate IV/310kD), mitochondrial
Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial
Respiratory chain complex I (intermediate VII/650kD), mitochondrial
Respiratory chain complex I (lambda subunit) mitochondrial
Respiratory chain complex I, mitochondrial
REST-CoREST-mSIN3A complex
RET-Rai complex
Retn homohexamer complex
Retn homotrimer complex
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A)
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B)
Retrotranslocation complex
RFC complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase.
RFC complex (activator A 1 complex)
RFC core complex A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.
RFC2-5 subcomplex
RFC2-RIalpha complex
RGS6-DNMT1-DMAP1 complex A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.
RHOA-IP3R-TRPC1 complex
RIAM-profilin complex
RIAM-Rap1-GTP complex
RIAM-VASP complex
Ribosome, cytoplasmic
RICH1-PAR3-aPKC polarity complex
RICH1/AMOT polarity complex, Flag-Amot precipitated
RICH1/AMOT polarity complex, Flag-Rich1 precipitated
RICTOR-mTOR complex
RIN1-STAM2-EGFR complex, EGF stimulated
RIN1-STAM2-HRS complex
Ripk2-Nod2 complex
RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
RNA pol II containing coactivator complex Tat-SF
RNA polymerase II (RNAPII)
RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying
RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying
RNA polymerase II complex, chromatin structure modifying
RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying
RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying
RNA polymerase II core complex
RNA polymerase II holoenzyme complex
RNA-induced silencing complex, RISC
Rnase/Mrp complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
RNF11-SMURF2-STAMBP complex
RNF20-RNF40-UbE2E1 complex
RPA complex
RPA-MSH4-BLM complex
Rpa2-Rrn3 complex
RPAP1-RPB2-RPB3 complex
RSmad complex
RUNX1-CBF-beta-DNA complex
Ryk-Dvl1 complex
Ryk-Wnt3a complex
Ryk-Wny1 complex
Ryk-Wny1-Fzd8 complex
S-phase-specific E2F-p107 complex
S100A10-annexin 2 complex
Sam68-p120GAP complex
Sam68-p85 P13K-IRS-1-IR signaling complex
SAP complex (Sin3-associated protein complex)
Sarcoglycan-sarcospan complex SG-SPN
Sarcoglycan-sarcospan-complex SG-SPN
Sarcoglycan-sarcospan-dystroglycan complex
Sarcoglycan-sarcospan-syntrophin-dystrobrevin complex
SCAMP1-SCAMP2 complex
SCAMP1-SCAMP2-SCAMP3 complex
SCF subcomplex (WEE1, SKP2, BTRC)
SCRIB-APC complex A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation.
Scrib-APC-beta-catenin complex A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation.
Scrib-beta-PIX-GIT1 complex
SCRIB-LGL2 complex
SCRIB-VANGL2 complex
Sdc2-Ephb2 complex
Sec6/8 exocyst complex
Sec61alpha-CollagenIV-Hsp47 complex
Securin-separase complex
SEMA4A-PlexinD1 complex
SEMA6D-PlexinA1-NRP1 complex
Septin complex A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric.
Serine-palmitoyltransferase (SPT) complex
SERPINA1-CTSG complex
SERPINA1-ELA2 complex
SERPINA3-CTSG complex
Set1A complex
Set1B complex
SETDB1-containing HMTase complex
SF3A1-SF3A2-SF3A3 complex
SF3b complex
SH3KBP1-CBLB-EGFR complex
Sh3kbp1-Cblb-Pdgfrb complex
SH3P2/OSTF1-CBL-SRC complex
SHARP-CtBP complex
SHARP-CtBP1-CtIP complex
SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex
SHARP-CtIP-RBP-Jkappa complex
SHC-GRB2 complex
Shc-Grb2-mSos1 complex, EGF stimulated A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
Shc-Ship-Grb2 complex, IL-3 stimulated
SHC3-GAB1 complex
Ship-Shc complex, IL-3 stimulated
SHP-NR5A2 complex
Shp2-Sos complex, FGF stimulated
SIN3 complex A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
SIN3-HDAC-SAP30-ARID4 complex
Sin3-Hdac1-Sds3 complex
SIN3-ING1b complex I
SIN3-ING1b complex II
SIN3-SAP25 complex
Sirpa-Pik3cg complex
SIRT1 homotrimer complex
SIRT1-HNF4-alpha-PGC-1-alpha complex, in response to fasting
Skeletal muscle sarcoglycan complex SGC, alpha-beta-epsilon-gamma
Skeletal muscle sarcoglycan complex SGC, alpha-beta-gamma-delta
Skeletal muscle sarcoglycan complex SGC, beta-gamma-delta-zeta
Skeletal muscle sarcoglycan complex SGC, epsilon-beta-gamma-delta
SKI complex A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
SKI-NCOR1-SIN3A-HDAC1 complex
SKI-SMAD2 hexameric complex
SKI-SMAD2-SMAD4 pentameric complex
SKI-SMAD3 hexameric complex
SKI-SMAD3-SMAD4 pentameric complex
Slam-SAP complex
Slam-SAP-FynT complex
Slam-SAP-SHIP complex
SLC1A2 homotrimer complex
SLP-76-Cbl-Grb2-Shc complex, Fc receptor gamma-R1 stimulated
SLP-76-PLC-gamma-1-ITK complex, alpha-TCR stimulated
SLP-76-PLC-gamma-1-VAV complex, alpha-TCR stimulated
Slp5-Rab27A complex
SMAD1-CBP complex
Smad1-Notch1-p300-Pcaf complex
SMAD1-P300 complex
SMAD2-FAST1 complex
SMAD2-SKI complex
SMAD2-SKI-NCOR complex
Smad2-Smad4 complex
SMAD2-SMAD4-FAST1 complex
SMAD3-cSKI-SIN3A-HDAC1 complex
SMAD3-E2F4/5-p107-DP1 complex
SMAD3-HEF1-APC10-CDH1 complex
SMAD3-SKI complex
SMAD3-SKI-NCOR complex
Smad3-Smad4 complex A heteromeric SMAD protein complex that contains SMAD3 and SMAD4.
SMAD3-SMAD4-cJUN complex
SMAD3-SMAD4-cJun-cFos complex
SMAD3-SMAD4-cSKI, TGF(beta)-dependent
SMAD3-SMAD4-CTCF protein-DNA complex
SMAD3-SMAD4-FOXO1 complex
SMAD3-SMAD4-FOXO3 complex
SMAD3-SMAD4-FOXO3-FOXG1 complex
SMAD3-SMAD4-FOXO4 complex
SMAD3-SMAD4-SP1 complex
SMAD3-VDR complex
SMAD3/4-E2F4/5-p107-DP1 complex
SMAD4-SKI complex
SMAD4-SKI-NCOR complex
SMAD4-SMAD2-SMAD3 complex
SMAD4-SNO-SKI complex
SMAD6-HOXA9 complex
SMAD6-HOXC8 complex
SMAD7-SMURF2 complex
SMARCA2/BRM-BAF57-MECP2 complex
Smarcb1/Ini1-Smarca2-Mecp2 complex
SMC1-SMC3 complex The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.
Smcb-Smcd-PW29 complex
SMCC complex
SMG-1-Upf1-eRF1-eRF3 complex (SURF)
SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
SMN complex (GEMIN2,5, SMN)
SMN complex (GEMIN5,2,3,4, SMN)
SMN complex (GEMIN5,4,3), SMN-independent intermediate
SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate
SMN complex, U7 snRNA specific
SMN containing complex
SMN-PolII-RHA complex
SMN1-SIP1-SNRP complex
Smooth muscle sarcoglycan complex SGC, beta-delta-zeta
SMRT complex
SMRT core complex
Smrt-Sin3A-Hdac7 complex
SMRT-SKIP-CBF1 complex
Smurf1-Par6 complex
SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent
SNAPc (small nuclear RNA-activating protein) complex
SNARE complex (HGS, SNAP25, STX13)
SNARE complex (RINT1, ZW10, p31)
SNARE complex (SNAP23, STX1A)
SNARE complex (SNAP25, VAMP3, VAMP2, NAPB, STX13)
SNARE complex (STX11, VAMP2, SNAP23)
SNARE complex (STX1A, SNAP29)
SNARE complex (STX2, SNAP23)
SNARE complex (STX4, SNAP23)
SNARE complex (STX4, SNAP23, VAMP1)
SNARE complex (STX4, SNAP23, VAMP2)
SNARE complex (Stx4, Stx6, Stx7, Vamp3, Vamp7, Vamp8, Vti1b)
SNARE complex (STX4, VAMP1, VAMP7)
SNARE complex (Stx4, Vamp2, Snap23)
SNARE complex (Stx4, Vamp8, Snap23)
SNARE complex (STX4, VAMP8, VAMP3, SNAP23)
SNARE complex (STX6, SNAP23)
SNARE complex (VAMP2, SNAP25, STX13)
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1) A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
SNARE complex (VAMP2, SNAP25, STX1a, CPLX1, CPLX3)
SNARE complex (VAMP2, SNAP25, STX1a, CPLX2) A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
SNARE complex (VAMP2, SNAP25, STX1a, CPLX3, CPLX4)
SNARE complex (VAMP2, SNAP25, STX1a, STX3, CPLX1, CPLX3, CPLX4)
SNARE complex (VAMP3, STX6, VTI1A)
SNARE complex (VAMP3, VAMP4, STX16) A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof).
SNARE complex (VAMP3, VAMP4, VAMP8, STX6)
SNARE complex (VAMP4, STX6, STX16, VTI1a, VTI1b)
SNARE complex (Vti1b, Stx6, Stx7)
SNARE complex (Vti1b, Stx7, Stx8, Vamp8)
SNF2h-cohesin-NuRD complex
SNF2h-HDAC12 complex
SNF2L-RSF1 complex
snRNP-free U1A (SF-A) complex
Snurportin-CRM1-RanGTP complex
SNW1 complex
SNX complex (SNX1, SNX6)
SNX complex (SNX1,1a,2,4, PDGF receptor)
SNX complex (SNX1a, SNX2, SNX4)
SNX complex (SNX1a, SNX2, SNX4, EGFR)
SNX complex (SNX1a, SNX2, SNX4, INSR)
SNX complex (SNX1a, SNX2, SNX4, LEPR)
SNX complex (SNX1a, SNX2, SNX4, TFRC)
SNX complex (SNX2), oligomeric
Sororin-cohesin complex
SORT1-NGFR complex
SORT1-NGFR-NGFB complex
Sos1-Abi1-Eps8 complex
SP1-E2F1 complex
SP1-MCAF2 complex
Spen-Hivep1 complex
Spliceosome Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
Splicing-associated factors complex
SRA-SRC-1 ribonucleoprotein complex
SRC-1 complex
SRC-3 complex
Src-dynamin-synapsin complex
SRC-PRKCD-CDCP1 complex
Src1-Ep300-Crebbp complex
SRCAP-associated chromatin remodeling complex
Srf-myogenin-E12 complex A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
SRI homodimer complex
SRm160-SRm300 complex
SRm160/300 complex
STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex)
STAGA core complex (SPT3-TAF9-GCN5 acetyltransferase complex)
Stat1-alpha-dimer-CBP DNA-protein complex
STAT3 homodimer copmplex
Stat3-Crebbp complex
STAT3-NLK-MAP3K7 complex
STAT5A homodimer complex
Stat5a-Jak2 complex
STAT5B homodimer complex
STAT6-p100-RHA complex
SUA1-UBA2 complex
Succinate dehydrogenase complex II (EC 1.3.5.1), mitochondrial
Succinyl-CoA synthetase, ADP-forming A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.
Succinyl-CoA synthetase, GDP-forming A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.
Sulphiredoxin-peroxiredoxin complex
SUMO1-SUA1-UBA2 complex
Sur2 subcomplex of mediator
Survivin homodimer complex
SVIP-p97/VCP-DERL1 complex
SWAP complex
SWI-SNF chromatin remodeling-related-BRCA1 complex
SWI/SNF chromatin-remodeling complex
SWI/SNF chromatin-remodeling complex (Mecp2, Smarc)
SWI/SNF-related complex
Sycp1-Syce1-Syce2 complex
Tacc1-chTOG-AuroraA complex
TAF4-TAF12 subcomplex of TFIID complex
TAJ-NgR1-LINGO-1 signaling complex
TALL1 homo-oligomer complex
TANK-TRAF2-TRAF3 complex
Tankyrin 1-tankyrin 2-TRF1 complex
tBID-BAK1 complex
TBP-TAF complex
TBPIP/HOP2-MND1 complex
TCF4-CTNNB1 complex
TCF4-CTNNB1-CREBBP complex
TCF4-CTNNB1-EP300 complex
TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex
TCL1(homotrimer) complex
TCL1(trimer)-AKT1 complex
TCL1(trimer)-AKT2 complex
TDT-TDIF2-core-histone complex
TEAD1-YAP DNA-protein complex
TEAD2-multiprotein complex A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others.
TEAD2-YAP DNA-protein complex
TEAD3-YAP DNA-protein complex
TEAD4-YAP DNA-protein complex
Telosome complex
TERF1 homodimer complex
TERF2-RAP1 complex
Ternary COG subcomplex
Ternary complex (Abl1, Dok1, Nck1)
Ternary complex (GATA4, SRF, MYOCD)
Ternary complex (LRRC7, CAMK2a, ACTN4)
Ternary complex (TRAF2, FADD, TRADD)
Tetrameric COG subcomplex
TF-FVIIa-FXa-TFPI complex
TFIIA complex
TFIIA-TRF2 complex
TFIID complex
TFIID complex, B-cell specific A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.
TFIID subcomplex
TFIID subcomplex, testis-specific
TFIID-beta complex
TFIIE complex
TFIIF complex (transcription factor IIF)
TFIIH transcription factor complex
TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2)
TFIIH transcription factor core complex
TFIIIC containing complex
TFIIIC containing complex TFIIIC2
TFIIIC containing-TOP1-SUB1 complex
TFTC complex (TATA-binding protein-free TAF-II-containing complex)
TFTC-type histone acetyl transferase complex
TGF-beta receptor
TGF-beta receptor I-Axin-SMAD3 complex
TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer.
TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex
TGF-beta receptor II-TGF-beta1 complex A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
TGF-beta receptor II-TGF-beta3 complex
TGF-beta receptor-SMAD3 complex
TGF-beta-receptor II-TGF-beta1 complex A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.
TGF-beta-receptor type II homodimer complex
TGF-beta-receptor-PAR6 complex
TGM2-HD complex
TGM2-HD-CALM1 complex
THO complex The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
THRB-RXRB complex
TIAM1-EFNB1-EPHA2 complex
TIAM1-GRIN1 complex
Tiam1-Par-3-aPKC-zeta complex
TICAM1-TICAM2-TLR4 complex
TIF-IB complex
TIF1gamma-SMAD2-SMAD3 complex
TIM (TIMM17ab, TIMM23, TIMM44) complex, mitochondrial
TIM (TIMM23, TIMM50) complex, mitochondrial
TIM (TIMM9, TIMM10) complex, mitochondrial
TIM50a-coilin complex
TIM50a-SMN1 complex
TIMM17-TIMM23 complex
TIN2 complex
TIP49-TIP48-BAF53 complex
TIP5-DNMT-HDAC1 complex
TIP60 histone acetylase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Tis7-Sin3-Hdac1-Ncor1-Sap30 complex
TLE-Histone H3 complex
TLE1 corepressor complex (MASH1 promoter-corepressor complex)
TLE1 homodimer complex
TLE1-TLE2 complex
TLE2 homodimer complex
Tle3-Aes complex A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.
TMP21-P24 complex
Tmsb4x-Lims1-Ilk complex
TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1)
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2)
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I)
TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)
TNF-alpha/NF-kappa B signaling complex 10
TNF-alpha/NF-kappa B signaling complex 5
TNF-alpha/NF-kappa B signaling complex 6
TNF-alpha/NF-kappa B signaling complex 7
TNF-alpha/NF-kappa B signaling complex 8
TNF-alpha/NF-kappa B signaling complex 9
TNFRSF11A-TRAF6-SRC complex
TNPO2-RAN-NXF1 complex
TOP1-PSF-P54 complex
Toposome
TorsinA-TorsinB complex
Tp53-BAK1 complex
TRAF2-cIAP1/BIRC2 complex
TRAF2-MALT1 complex
TRAF2-TRADD complex
TRAF6 oligomer complex
TRAF6-MALT1 complex
Traf6-p62-aPKC complex, RANK-L stimulated
TRAF6-TAK1 complex
Transcription elongation factor complex (SUPT5H, CDK9, CCNT1)
Transcription initiation factor complex (TAF1, TAF5, TAF11, TAF12, TBP)
Transcription initiation factor complex (TAF5, TAF6, TAF9, TAF11, TBP)
TRAP complex
TRAP-SMCC mediator complex
TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)
TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10)
TREX complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.
TRF-Rap1 complex I, 2MD
TRF1 telomere length regulation complex
TRF1-TIN2 complex
TRF2-Ku complex
TRF2-Rap1 complex II
TRF2-Rap1 complex III
TRIB3-DDIT3 complex
TRIKA2 protein kinase complex (TAK1, TAB1, TAB2)
TRIM27-RB1 complex
Trip(Br1)-Dp1-E2F1 complex
Trip(Br2)-Dp1-E2F1 complex
Tripeptidyl peptidase
tRNA splicing endonuclease
TRP1-G alpha-11-IP3R3-CAV1 signaling complex
Trpc1-dystrophin-alpha1-syntrophin complex
TRPC1-STIM1-ORAI1 complex
TRPC1-TRPC3-TRPC7 complex
TRPC3-TRPC4 channel complex, redox-sensitive
TRPV5-S100A10-annexin 2 complex
TRRAP-BAF53-HAT complex
TSC1-TSC2 complex A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.
TSG101-VPS37B-VPS28 complex
TTP-AGO2 complex
TTP-AGO4 complex
Tubulin polyglutamylase complex
Tumor necrosis factor receptor 1 signaling complex
Ubiquilin-proteasome complex
Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
Ubiquitin E3 ligase (BMI1, SPOP, CUL3)
Ubiquitin E3 ligase (CDC34, CUL1, RBX1)
Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1)
Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
Ubiquitin E3 ligase (CHEK1, CUL1)
Ubiquitin E3 ligase (CHEK1, CUL4A)
Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)
Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)
Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3)
Ubiquitin E3 ligase (CUL1, RBX1, SKP1A)
Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
Ubiquitin E3 ligase (Fbxl20, Skp1, Cul1)
Ubiquitin E3 ligase (Fbxo15, Cul1, Skp1a)
Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1)
Ubiquitin E3 ligase (Fbxo2, Skp1a, Cul1, Rbx1)
Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1)
Ubiquitin E3 ligase (Fbxo32, Skp1a, Cul1, Rbx1)
Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1)
Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)
Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1)
Ubiquitin E3 ligase (H2AFY, SPOP, CUL3)
Ubiquitin E3 ligase (Neurl2, Tceb1, Tceb2, Cul5, Rbx1)
Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A)
Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A)
Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A)
Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1)
Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X)
Ubiquitin E3 ligase (SKP1A, BTRC, CUL1)
Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1)
Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1)
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1)
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1)
Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1)
Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1)
Ubiquitin E3 ligase (SPOP, DAXX, CUL3)
Ubiquitin E3 ligase (TRIM25, DDX58)
Ubiquitin E3 ligase (UBADC1, RNF123)
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2)
Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1)
Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10)
Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2)
Ubiquitin-protein-ligase (UBE2N, UBE2V2/MMS2)
uKHC-KLC1-KLC2 kinesin complex
ULBP1-KLRK1-HCST complex
ULBP2-KLRK1-HCST complex
ULBP3-KLRK1-HCST complex
Upf complex (UPF1, UPF2, UPF3a)
Upf complex (UPF1, UPF2, UPF3b)
URI complex (Unconventional prefoldin RPB5 Interactor)
USP1-UAF1 complex
UTM-SGCE-DAG1-CAV1-NOS3 complex
UTX-MLL2/3 complex
VAM1-VELI1 complex
Vdr-Med4 complex
VEGF transcriptional complex
VEGFA(165)-KDR-NRP1 complex
VEGFA(165)-VEGFR2-NRP1 complex
Vezf1-p68RacGap complex
VHL-TBP1-HIF1A complex
VHL-TCEB1-TCEB2 complex
VHL-VDU1-TCEB1-TCEB2 complex
Vigilin-DNA-PK-Ku antigen complex
VILIP-1-AChR-alpha-4-AChR-beta-2 complex
Vps29-Vps35-Vps26a complex
VPS35-VPS29-VPS26A complex
Wave-2 complex
Wave-2 complex (Rac-activated)
Wave1-Bcl-xl-Pancortin-2 complex, focal ischemic stroke induced
WCRF complex
WDR5-ASH2L-RBBP5-MLL2 complex
Whrn homodimer complex
WICH complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair.
WINAC complex
WIP-WASp-actin-myosin-IIa complex
WNK1-OSR1 complex
WNK1-SPAk complex
WRN-Ku70-Ku80-PARP1 complex
WRN-TRF2 complex
XFIM complex
Xin-Cdh2-Ctnnb1-Ctnnd1 complex
XPA-ERCC1-ERCC4 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.
XRCC1-LIG3-PNK-TDP1 complex
Y14-Magoh complex
YBX1-AKT1 complex
YWHAQ-CALM1-CABIN1 complex
YY1-MDM2-p53 complex
YY1-Notch1 complex
YY1-Notch1-RBP-Jkappa complex
Yy1-Ppargc1a complex
Yy1-Ppargc1a-Frap1 complex
ZAP70-CRKL-WIPF1-WAS complex
ZNF198-PML complex
ZNF198-SUMO1 complex
ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex