Achilles Cell Line Gene Essentiality Profiles Dataset

Description fitness scores for cell lines following single gene knockdowns
Measurement relative cell proliferation
Association gene-cell line associations by sensitivity of cell line to gene knockdown
Category disease or phenotype associations
Resource Achilles
Citation(s)
Last Updated
Stats
  1. 4831 genes
  2. 216 cell lines
  3. 104046 gene-cell line associations

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  • Attribute Similarity

  • Dataset

  • Gene Similarity

cell line Gene Sets

216 sets of gene knockdowns changing fitness of each cell line relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

Gene Set Description
22RV1 Human prostate carcinoma cell line; derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft.
697 Human B cell precursor leukemia; established from the bone marrow of a 12-year-old boy with acute lymphoblastic leukemia (cALL) at relapse in 1979.
786O Human renal cell adenocarcinoma cell line, established from a 58 years old caucasian male.
A1207
A172 A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0183(Deposited from Tohoku Univ.).
A204
A2058 Human skin melanoma cell line, established from a 43 years adult caucasian male.
A549 Human lung carcinoma established from an explanted lung tumor which was removed from a 58-year-old Caucasian man in 1972; cells were described to induce tumors in athymic mice and to synthesize lecithin.
A673
ACHN
AGS
AM38
AML193
ASPC1
BT20 Human, Caucasian, breast, carcinoma cell line. Morphology: epithelial-like; species: human, Caucasian female 74 years old; tissue: breast; tumor: carcinoma.
BT474
BXPC3 Human pancreatic adenocarcinoma cell line, established from a 61 year old human female.
C2BBE1 The C2BBe1 (brush border expressing) cell line was cloned in 1988 from the Caco-2 cell line by limiting dilution.
C32
CADOES1
CAL120 disease: adenocarcinoma, breast
CAL51
CALU1
CAOV3
CAOV4 disease: adenocarcinoma (ovary primary)
CAS1
CFPAC1 This line was derived from a pancreatic duct adenocarcinoma (liver metastasis) from a patient with cystic fibrosis.
CH157MN cell line derived from central nervous system
COLO205
COLO704
COLO741 disease: carcinoma, colon
COLO783
CORL23 disease: carcinoma, large cell
COV362 cell line derived from ovary
COV434 cell line derived from ovary
COV504 cell line derived from ovary
COV644 cell line derived from ovary
DBTRG05MG
DKMG
DLD1 Human colon adenocarcinoma established from a colorectal adenocarcinoma.
EFE184
EFM19
EFO21 disease: cystoadenocarcinoma
EFO27 Human ovary adenocarcinoma cell line; established from the solid omental metastasis of a mucinous papillary adenocarcinoma of the ovary of a 36-year-old woman in 1979.
EW8 cell line derived from bone
EWS502 cell line derived from bone
F36P A immortal human bone marrow-derived cell line cell that has the characteristics: GM-CSF- or IL-3-dependent cell line. Differentiate to erythoid cells with erythropoietin.
GB1 cell line derived from central nervous system
GP2D
HCC1187 disease: primary ductal carcinoma
HCC1395
HCC1954
HCC2218 disease: primary ductal carcinoma
HCC2814 cell line derived from lung
HCC364 cell line derived from lung
HCC44
HCC70 disease: primary ductal carcinoma
HCC827
HCC827GR5 cell line derived from lung
HCT116 Human colon colorectal carcinoma cell line from a male organism. Human colon carcinoma cell line; established from the primary colon carcinoma of an adult man.
HEC1A
HEYA8 cell line derived from ovary
HL60 Human acute myeloid leukemia established from the peripheral blood of a 35-year-old woman with acute myeloid leukemia (AML FAB M2) in 1976.
HLF cell line derived from liver
HNT34 A immortal human blood cell line cell that has the characteristics: AML with Ph' chromosome and t(3;3)(q21;q26). Expressing EVI-1 and BCR/ABL mRNA.
HPAC
HPAFII
HS683 Human brain glioma cell line. Hs 683 was isolated from explant cultures of a glioma taken from the left temporal lobe of a 76 year old male Caucasian.
HS766T Human pancreatic cancer cell line.
HS944T disease: melanoma (skin primary)
HT1197
HT29
HT55
HUG1N A immortal human stomach-derived cell line cell that has the characteristics: Stomach cancer, but producing Nagao-type alkaline phosphatase. See HuG1-PI.
HUTU80
IGR39
IGROV1
IOMMLEE Malignant meningioma cell line.
JHESOAD1 cell line derived from oesophagus
JHOC5 A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Clear cell adenocarcinoma. Said CA125, CA72-4 producing.
JHOM1 A immortal human ovary-derived fibroblast cell line cell that has the characteristics: Human ovary mucinous adenocarcinoma cell line.
JJN3 cell line derived from haematopoietic_and_lymphoid_tissue
K562 Human chronic myeloid leukemia in blast crisis established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970.
KALS1
KASUMI1 Human acute myelocytic leukemia cell line; derived from the peripheral blood of a 7-year-old japanese boy with acute myelocytic leukemia in relapse after bone marrow transplantation.
KM12 Human colon carcinoma cell line.
KMS12BM cell line derived from haematopoietic_and_lymphoid_tissue
KNS60 cell line derived from central_nervous_system
KNS81 cell line derived from central nervous system
KP1NL cell line derived from pancreas
KP2 Human pancreatic cancer cell line of primary pancreatic origin.
KP4 A immortal human cell line cell that has the characteristics: Pancreatic ductal cell carcinoma. Mother cell line of KP4-1, -2, and -3.
KURAMOCHI
KYSE150 Human esophageal squamous cell carcinoma cell line; established from the poorly differentiated esophageal squamous cell carcinoma resected from upper (cervical) esophagus of a 49-year-old Japanese woman after receiving radiotherapy.
KYSE30
KYSE450 disease: carcinoma, squamous cell
KYSE510 disease: carcinoma, squamous cell
L33 Human pancreatic cancer cell line.
L363 Multiple myeloma cell line expressing syndecan-1.
LAMA84 Human chronic myeloid leukemia in blast crisis; established from the peripheral blood of a 29-year-old woman with chronic myeloid leukemia.
LK2 A immortal human cell line cell that has the characteristics: Human lung squamous cell carcinoma cell line.TKG0494 (Deposited from Tohoku Univ.).
LN215 Human glioblastoma cell line.
LN229 Human brain, right frontal parieto-occipital cortex, glioblastoma cell line; established from a 60 years old white female.
LN235 Human glioblastoma cell line.
LN319 Anaplastic astrocytoma cell line.
LN340 Human glioblastoma cell line.
LN382 Human glioblastoma cell line.
LN428 Human glioblastoma cell line.
LN443 Human glioblastoma cell line.
LN464 Human glioblastoma cell line.
LNZ308 Human glioblastoma cell line.
LOVO A immortal human colon-derived cell line cell that has the characteristics: CEA-producing colon adenocarcinoma. Back up culture of ECA2739. Cell growth is slow.
LS411N disease: colorectal carcinoma
LS513 disease: colorectal carcinoma
MCF7 A immortal human breast-derived cell line cell that has the characteristics: Human cell line derived from breast adenocarcinoma. TKG0479 (Deposited from Tohoku Univ.).
MDAMB453
MIAPACA2 A immortal human cell line cell that has the characteristics: Human cell line derived from pancreatic cancer. TKG0227(Deposited from Tohoku Univ.)
MKN7 A immortal human stomach-derived cell line cell that has the characteristics: c-erbB-2 expressing gastric adenocarcinoma. Differentiated type.
MM1S Human B lymphoblast multiple myeloma cell line.
MOLM13 Human acute myeloid leukemia cell line; established from the peripheral blood of a 20-year-old man with acute myeloid leukemia AML FAB M5a at relapse in 1995 after initial myelodysplastic syndromes.
MONOMAC1 Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Simultaneous sister cell line of MONO-MAC-6.
MONOMAC6 Human acute monocytic leukemia cell line; established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia (AML FAB M5) in 1985 following myeloid metaplasia. Sister cell line of MONO-MAC-1.
MV411 Human acute myelocytic leukemia cell line.
NALM6
NB4
NCIH1299
NCIH1437
NCIH1650
NCIH1792 disease: adenocarcinoma (lung primary)
NCIH196 Small cell lung cancer cell line.
NCIH1975
NCIH2052 disease: mesothelioma (pleura primary)
NCIH2122
NCIH2171 disease: carcinoma; small cell lung cancer (lung primary)
NCIH23
NCIH2452 disease: mesothelioma
NCIH441
NCIH508 disease: colorectal adenocarcinoma
NCIH660 Homo sapiens (human) lung; small cell lung cancer cell line, extrapulmonary origin; established from a 63 years adult caucasian male. Morphology: epithelial; cell type: neuroendocrine; Tumor stage E; derived from metastatic site: lymph node.
NCIH661
NCIH716
NCIH838
NCIN87
NIHOVCAR3 Human caucasian ovary adenocarcinoma cell line; established from a 60 years old caucasian female.
NOMO1
OAW42 disease: cystoadenocarcinoma
OCIAML2 Human acute myeloid leukemia cell line; established from the peripheral blood of a 65-year-old man with acute myeloid leukemia.
OCIAML3 Human acute myeloid leukemia cell line; established from the peripheral blood of a 57-year-old man with acute myeloid leukemia.
OCIAML5 Human acute myeloid leukemia cell line; established from the peripheral blood of a 77-year-old man with acute myeloid leukemia.
OE33
OELE cell line derived from ovary
OPM2
OV7 cell line derived from ovary
OV90
OVCAR4
OVCAR8
OVISE Human ovarian carcinoma cell line from clear cell adenocarcinoma.
PANC0327
PANC0813
PANC1005 disease: adenocarcinoma; same patient as PL45
PLB985
PSN1 Human pancreatic adenocarcinoma cell line.
QGP1 Human pancreatic neuroendocrine tumor cell line.
REH Human B cell precursor leukemia established from the peripheral blood of a 15-year-old North African girl with acute lymphoblastic leukaemia, ALL at first relapse, in 1973.
RKN cell line derived from soft_tissue
RKO
RMGI Human tumor cell line from ovarian mesonephroid adenocarcinoma.
RMUGS cell line derived from ovary
RS411 Human B cell precursor leukemia cell line; established from the bone marrow of a 32-year-old woman with acute lymphoblastic leukemia (ALL L2) in first relapse.
RT112 Human urinary bladder transitional cell carcinoma established from the transitional cell carcinoma histological grade G2 excised from a female patient with untreated primary urinary bladder carcinoma in 1973.
SEM
SF126
SF172 cell line derived from central nervous system
SF295
SF767 Human glioblastoma cell line.
SJSA1
SKCO1 disease: colorectal adenocarcinoma (colon primary)
SKMEL5 Human caucasian skin melanoma cell line; established from a 24 year old Caucasian female. Derived from: axillary node.
SKMM2
SKNO1 cell line derived from haematopoietic and lymphoid tissue
SKOV3
SKRC20 cell line derived from kidney
SLR20 cell line derived from kidney
SLR21 cell line derived from kidney
SLR23 cell line derived from kidney
SLR24 cell line derived from kidney
SLR25 cell line derived from kidney
SLR26 cell line derived from kidney
SNU1105 cell line derived from central_nervous_system
SNU840 cell line derived from ovary
SNUC1 disease: adenocarcinoma colon primary)
SNUC2A disease: colorectal carcinoma
SU8686 Homo sapiens (human) pancreatic adenocarcinoma cell line. The line was developed from a wedge biosy of a liver metastasis of a pancreatic ductal carcinoma.
SW1417
SW1783 disease: astrocytoma
SW48
SW480
T98G A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471(Deposited from Tohoku Univ.).
TC71
TCCSUP disease: transitional cell carcinoma
TE10 A immortal human esophagus-derived cell line cell that has the characteristics: Human cell line derived from esophageal cancer. Highly differentiated squamous cell carcinoma. TKG0261(Deposited from Tohoku Univ.).
TE15 Human esophageal squamous cell carcinoma cell line.
TE9 A immortal human esophagus-derived cell line cell that has the characteristics: Human esophageal squamous cell carcinoma (poorly differentiated) cell line. Not transplantable to nude mouse. TKG0260 (Deposited from Tohoku Univ.).
THP1
TOV112D TOV-112D is a human epithelial cell line initiated in October of 1992 from a patient with early onset ovarian cancer. The patient was of French-Canadian descent with an unknown family history of ovarian cancer.
TOV21G This cell line was initiated in October of 1991 from a patient of French-Canadian descent with no family history of ovarian cancer.
TT
TYKNU
U178 cell line derived from central nervous system
U251MG Human glioma cell line. Morphology: glial; Species: human; Tumor: glioma.
U343 Human glioma cell line.
U87MG Human, Caucasian, brain, glioblastoma-astrocytoma cell line Morphology: epithelial-like; Species: human, Caucasian female 44 years old; Tissue: brain; Tumor: glioblastoma-astrocytoma.
UOK101 cell line derived from kidney
VCAP Human prostate cancer cell line.
YKG1 A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma. TKG0453(Deposited from Tohoku Univ.).
ZR7530